Age-related gene-specific changes of A-to-I mRNA editing in the human brain

• Published in: Mechanisms of ageing and development Vol. 131; no. 6; pp. 445 - 447
• Main Authors: Nicholas, A., de Magalhaes, J.P., Kraytsberg, Y., Richfield, E.K., Levanon, E.Y., Khrapko, K.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.2010; Elsevier
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Adenosine - genetics; Adenosine - metabolism; Adult; Aged; Aged, 80 and over; Aging; Aging - genetics; Aging - metabolism; Biological and medical sciences; Cerebral Cortex - metabolism; Female; Fundamental and applied biological sciences. Psychology; Genes. Genome; Human brain; Humans; Inosine - genetics; Inosine - metabolism; Male; Middle Aged; Molecular and cellular biology; Molecular genetics; Receptors, GABA-A - genetics; Receptors, GABA-A - metabolism; RNA Editing; Young Adult; Aging; Human brain; RNA editing; Human; Brain; Senescence; Messenger RNA; Gene; Ageing; Central nervous system; Age; Encephalon

A-to-I editing is an adenosine-to-inosine modification of mRNA particularly widespread in the human brain, where it affects thousands of genes. A growing body of evidence suggests that A-to-I RNA editing is necessary for normal development and maintenance in mammals and that its deficiencies contrib...