Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance

• Published in: The Journal of clinical investigation Vol. 132; no. 9; pp. 1 - 20
• Main Authors: Huang, Yanrui, Zhou, Jenny H., Zhang, Haifeng, Canfran-Duque, Alberto, Singh, Abhishek K., Perry, Rachel J., Shulman, Gerald I., Fernandez-Hernando, Carlos, Min, Wang
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 02.05.2022
• Subjects: Adipose tissue (brown); Adipose Tissue, Brown - metabolism; Animals; Biomedical research; Body fat; Diet; Diet, High-Fat; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Energy Metabolism; Hypertriglyceridemia; Immune response; Inflammasomes; Inflammation; Inflammation - genetics; Inflammation - metabolism; Innate immunity; Insulin; Insulin resistance; Insulin Resistance - physiology; Lipid metabolism; Metabolism; Mice; Mice, Inbred C57BL; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial DNA; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Oxidative stress; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; Thermogenesis; Thermogenesis - genetics; Thioredoxin; Thioredoxins - genetics; Thioredoxins - metabolism; Innate immunity; Mitochondria; Inflammation; Adipose tissue; Metabolism

Brown adipose tissue (BAT), a crucial heat-generating organ, regulates whole-body energy metabolism by mediating thermogenesis. BAT inflammation is implicated in the pathogenesis of mitochondrial dysfunction and impaired thermogenesis. However, the link between BAT inflammation and systematic metabo...