Significance of Gene Diagnosis in Acute Myeloid Leukemia with the Emergence of New Molecular Target Drug Treatment

• Published in: Journal of Nippon Medical School Vol. 89; no. 5; pp. 470 - 478
• Main Author: Yamaguchi, Hiroki
• Format: Journal Article
• Language: English
• Published: The Medical Association of Nippon Medical School 01.01.2022
• Subjects: acute myeloid leukemia; allogeneic hematopoietic cell transplantation; FLT3 inhibitor; gene diagnosis; molecular target drug treatment

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy accompanied by impaired differentiation and autonomous proliferation of hematopoietic stem cells. Standard induction therapy results in first complete remission among 70% of patients with AML; however, approximately half of the...