Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation

• Published in: Immunity (Cambridge, Mass.) Vol. 39; no. 1; pp. 136 - 147
• Main Authors: Kometani, Kohei, Nakagawa, Rinako, Shinnakasu, Ryo, Kaji, Tomohiro, Rybouchkin, Andrei, Moriyama, Saya, Furukawa, Koji, Koseki, Haruhiko, Takemori, Toshitada, Kurosaki, Tomohiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.07.2013; Elsevier Limited
• Subjects: Animals; Antigens; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - immunology; Basic-Leucine Zipper Transcription Factors - metabolism; Cell Differentiation - genetics; Cell Differentiation - immunology; Cells, Cultured; Flow Cytometry; Gene Expression - immunology; Immune system; Immunoglobulin G - immunology; Immunoglobulin G - metabolism; Immunoglobulins; Immunologic Memory - immunology; Medical research; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; PAX5 Transcription Factor - genetics; PAX5 Transcription Factor - immunology; PAX5 Transcription Factor - metabolism; Plasma Cells - immunology; Plasma Cells - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; TOR Serine-Threonine Kinases - immunology; TOR Serine-Threonine Kinases - metabolism

Memory B cells are essential for generating rapid and robust secondary antibody responses. It has been thought that the unique cytoplasmic domain of IgG causes the prompt activation of antigen-experienced IgG memory B cells. To assess this model, we have generated a mouse containing IgG1 B cells tha...