Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant
Investigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral drugs against Covid-19 variants of concern. All the antibodies showed either no or weak neutralizing activity against the omicron variant; two agents that target the RNA polymerase and a protease inhibi...
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| Published in | The New England journal of medicine Vol. 386; no. 10; pp. 995 - 998 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Massachusetts Medical Society
10.03.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Investigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral drugs against Covid-19 variants of concern. All the antibodies showed either no or weak neutralizing activity against the omicron variant; two agents that target the RNA polymerase and a protease inhibitor were effective at omicron neutralization. |
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| AbstractList | Investigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral drugs against Covid-19 variants of concern. All the antibodies showed either no or weak neutralizing activity against the omicron variant; two agents that target the RNA polymerase and a protease inhibitor were effective at omicron neutralization. Monoclonal Antibody and Antiviral Activity against OmicronInvestigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral drugs against Covid-19 variants of concern. All the antibodies showed either no or weak neutralizing activity against the omicron variant; two agents that target the RNA polymerase and a protease inhibitor were effective at omicron neutralization. |
| Author | Takashita, Emi Yotsuyanagi, Hiroshi Adachi, Eisuke Takeda, Makoto Watanabe, Shinji Ohmagari, Norio Kinoshita, Noriko Iwatsuki-Horimoto, Kiyoko Saito, Makoto Pekosz, Andrew Yamayoshi, Seiya Maeda, Kenji Fujisaki, Seiichiro Mitsuya, Hiroaki Sullivan, David Nagai, Hiroyuki Kawaoka, Yoshihiro Sakai-Tagawa, Yuko Imai, Masaki Ito, Mutsumi Hasegawa, Hideki Chiba, Shiho Halfmann, Peter |
| Author_xml | – sequence: 1 givenname: Emi surname: Takashita fullname: Takashita, Emi organization: National Institute of Infectious Diseases, Tokyo, Japan – sequence: 2 givenname: Noriko surname: Kinoshita fullname: Kinoshita, Noriko organization: National Center for Global Health and Medicine, Tokyo, Japan – sequence: 3 givenname: Seiya surname: Yamayoshi fullname: Yamayoshi, Seiya organization: University of Tokyo, Tokyo, Japan – sequence: 4 givenname: Yuko surname: Sakai-Tagawa fullname: Sakai-Tagawa, Yuko organization: University of Tokyo, Tokyo, Japan – sequence: 5 givenname: Seiichiro surname: Fujisaki fullname: Fujisaki, Seiichiro organization: National Institute of Infectious Diseases, Tokyo, Japan – sequence: 6 givenname: Mutsumi surname: Ito fullname: Ito, Mutsumi organization: University of Tokyo, Tokyo, Japan – sequence: 7 givenname: Kiyoko surname: Iwatsuki-Horimoto fullname: Iwatsuki-Horimoto, Kiyoko organization: University of Tokyo, Tokyo, Japan – sequence: 8 givenname: Shiho surname: Chiba fullname: Chiba, Shiho organization: University of Wisconsin–Madison, Madison, WI – sequence: 9 givenname: Peter surname: Halfmann fullname: Halfmann, Peter organization: University of Wisconsin–Madison, Madison, WI – sequence: 10 givenname: Hiroyuki surname: Nagai fullname: Nagai, Hiroyuki organization: University of Tokyo, Tokyo, Japan – sequence: 11 givenname: Makoto surname: Saito fullname: Saito, Makoto organization: University of Tokyo, Tokyo, Japan – sequence: 12 givenname: Eisuke surname: Adachi fullname: Adachi, Eisuke organization: University of Tokyo, Tokyo, Japan – sequence: 13 givenname: David surname: Sullivan fullname: Sullivan, David organization: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD – sequence: 14 givenname: Andrew surname: Pekosz fullname: Pekosz, Andrew organization: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD – sequence: 15 givenname: Shinji surname: Watanabe fullname: Watanabe, Shinji organization: National Institute of Infectious Diseases, Tokyo, Japan – sequence: 16 givenname: Kenji surname: Maeda fullname: Maeda, Kenji organization: National Center for Global Health and Medicine, Tokyo, Japan – sequence: 17 givenname: Masaki surname: Imai fullname: Imai, Masaki organization: University of Tokyo, Tokyo, Japan – sequence: 18 givenname: Hiroshi surname: Yotsuyanagi fullname: Yotsuyanagi, Hiroshi organization: University of Tokyo, Tokyo, Japan – sequence: 19 givenname: Hiroaki surname: Mitsuya fullname: Mitsuya, Hiroaki organization: National Center for Global Health and Medicine, Tokyo, Japan – sequence: 20 givenname: Norio surname: Ohmagari fullname: Ohmagari, Norio organization: National Center for Global Health and Medicine, Tokyo, Japan – sequence: 21 givenname: Makoto surname: Takeda fullname: Takeda, Makoto organization: National Institute of Infectious Diseases, Tokyo, Japan – sequence: 22 givenname: Hideki surname: Hasegawa fullname: Hasegawa, Hideki organization: National Institute of Infectious Diseases, Tokyo, Japan – sequence: 23 givenname: Yoshihiro surname: Kawaoka fullname: Kawaoka, Yoshihiro email: yoshihiro.kawaoka@wisc.edu organization: University of Tokyo, Tokyo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35081300$$D View this record in MEDLINE/PubMed |
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| Notes | SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 14 ObjectType-Article-2 content type line 23 Drs. Takashita and Kinoshita contributed equally to this letter. |
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| References | Corti, D, Purcell, LA, Snell, G, Veesler, D (r3) 2021; 184 (r1) 2021 Bansal, K, Kumar, S (r5) 2021 Planas, D, Veyer, D, Baidaliuk, A (r4) 2021; 596 Qin, S, Cui, M, Sun, S (r2) 2021 e_1_3_4_3_2 e_1_3_4_2_2 e_1_3_4_6_2 e_1_3_4_5_2 e_1_3_4_4_2 |
| References_xml | – year: 2021 ident: r1 article-title: Coronavirus disease (COVID-19) weekly epidemiological update and weekly operational update ;(https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---7-december-2021) – volume: 596 start-page: 276 year: 2021 end-page: 280 ident: r4 article-title: Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization. publication-title: Nature – year: 2021 ident: r5 article-title: Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant. ;(https://www.biorxiv.org/content/10.1101/2021.12.06.471389v1) publication-title: preprint – volume: 184 start-page: 3086 year: 2021 end-page: 3108 ident: r3 article-title: Tackling COVID-19 with neutralizing monoclonal antibodies. publication-title: Cell – year: 2021 ident: r2 article-title: Genome characterization and potential risk assessment of the novel SARS-CoV-2 variant omicron (B.1.1.529). ;(https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2021-0024) publication-title: Zoonoses – ident: e_1_3_4_3_2 doi: 10.15212/ZOONOSES-2021-0024 – ident: e_1_3_4_4_2 doi: 10.1016/j.cell.2021.05.005 – ident: e_1_3_4_5_2 doi: 10.1038/s41586-021-03777-9 – ident: e_1_3_4_2_2 – ident: e_1_3_4_6_2 doi: 10.1101/2021.12.06.471389 |
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| Snippet | Investigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral drugs against Covid-19 variants of concern. All the... Monoclonal Antibody and Antiviral Activity against OmicronInvestigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral... |
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| SubjectTerms | Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antiviral activity Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Coronavirus Coronaviruses Correspondence COVID-19 COVID-19 Drug Treatment DNA-directed RNA polymerase Drugs Enzyme-Linked Immunosorbent Assay FDA approval Infectious Disease Infectious diseases Influenza Monoclonal antibodies Mutation Neutralization Tests Pathogenesis Proteinase inhibitors Proteins R&D Research & development RNA polymerase SARS-CoV-2 - drug effects SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 |
| SubjectTermsDisplay | Coronavirus Infectious Disease |
| Title | Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant |
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