Alcoholic liver disease: pathogenesis and new targets for therapy

• Published in: Nature reviews. Gastroenterology & hepatology Vol. 8; no. 9; pp. 491 - 501
• Main Authors: Altamirano, José, Bataller, Ramón
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2011; Nature Publishing Group
• Subjects: 692/420; 692/699/1503/1607/1608; 692/700/478/174; 692/700/565/1436/2185; Animals; Biomedicine; Chemokines, CXC - drug effects; Disease Models, Animal; Gastroenterology; Hepatology; Humans; Liver Diseases, Alcoholic - drug therapy; Liver Diseases, Alcoholic - epidemiology; Liver Diseases, Alcoholic - etiology; Medicine; Medicine & Public Health; Osteopontin - drug effects; Prevalence; Receptors, Tumor Necrosis Factor - drug effects; review-article; Spain

Despite its high prevalence worldwide, alcoholic liver disease (ALD) has attracted little attention in the past two decades. Abstinence has been the most effective therapy, but targeted therapies are required for severe forms. Novel potential therapeutic targets have been identified, but their patho...