KIT polymorphisms and mutations determine responses of neoplastic mast cells to bafetinib (INNO-406) - Peter, Barbara; Hadzijusufovic, Emir; Blatt, Katharina; Gleixner, Karoline V.; Pickl, Winfried F.; Thaiwong, Tuddow; Yuzbasiyan-Gurkan, Vilma; Willmann, Michael; Valent, Peter (Experimental hematology, 2010)
Keywords: Advanced Basic Science; Amino Acid Substitution; Animals; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Exons - genetics; Gene Expression Regulation, Enzymologic - drug effects; Gene Expression Regulation, Enzymologic - genetics; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Hematology, Oncology and Palliative Medicine; Humans; Mast Cells - enzymology; Mast Cells - pathology; Mastocytosis, Systemic - drug therapy; Mastocytosis, Systemic - enzymology; Mastocytosis, Systemic - genetics; Mastocytosis, Systemic - pathology; Mutation, Missense; Phosphorylation - drug effects; Phosphorylation - genetics; Polymorphism, Genetic; Protein Kinase Inhibitors - pharmacology; Proto-Oncogene Proteins c-kit - antagonists & inhibitors; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Pyrimidines - pharmacology; Species Specificity