Big science for vaccine development
[...]the regulatory environment, the number of subjects and the complexity of clinical testing changed so much that only big companies with a large capacity of human and financial resources can afford to bring vaccines to the finish line. [...]once proof of concept in humans is achieved, a private i...
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| Published in | Vaccine Vol. 32; no. 37; pp. 4705 - 4707 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
20.08.2014
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | [...]the regulatory environment, the number of subjects and the complexity of clinical testing changed so much that only big companies with a large capacity of human and financial resources can afford to bring vaccines to the finish line. [...]once proof of concept in humans is achieved, a private industrial partner needs to take the leadership to industrialize the process, get regulatory approval and commercialize the vaccine. |
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| AbstractList | [...]the regulatory environment, the number of subjects and the complexity of clinical testing changed so much that only big companies with a large capacity of human and financial resources can afford to bring vaccines to the finish line. [...]once proof of concept in humans is achieved, a private industrial partner needs to take the leadership to industrialize the process, get regulatory approval and commercialize the vaccine. |
| Author | Rappuoli, Rino Medaglini, Donata |
| Author_xml | – sequence: 1 givenname: Rino surname: Rappuoli fullname: Rappuoli, Rino email: rino.rappuoli@novartis.com organization: Novartis Vaccines, Via Fiorentina 1, Siena 53100, Italy – sequence: 2 givenname: Donata surname: Medaglini fullname: Medaglini, Donata email: donata.medaglini@unisi.it organization: Laboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24975815$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_7774_cevr_2015_4_1_46 crossref_primary_10_1126_scitranslmed_aad3106 crossref_primary_10_3389_fimmu_2020_00878 crossref_primary_10_1177_0033354917714233 crossref_primary_10_5812_jamm_12315 crossref_primary_10_1016_j_vaccine_2017_11_069 crossref_primary_10_1016_j_vaccine_2016_10_084 crossref_primary_10_1089_aid_2015_0101 crossref_primary_10_1093_police_paad006 crossref_primary_10_1016_j_vaccine_2018_10_061 crossref_primary_10_3389_fmicb_2016_02004 crossref_primary_10_1007_s40124_016_0109_0 |
| Cites_doi | 10.1038/nrmicro2668 10.1126/science.134.3473.161 10.1038/nm0497-374 10.1126/scitranslmed.3003826 |
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| Copyright | 2014 Elsevier Ltd Elsevier Ltd Copyright Elsevier Limited Aug 20, 2014 |
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| DOI | 10.1016/j.vaccine.2014.06.071 |
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| References | Rappuoli (bib0020) 1997; 3 Plotkin, Plotkin (bib0015) 2011; 9 Weinberg (bib0025) 1961; 134 Rappuoli, Medaglini (bib0040) 2012; 4 bib0055 bib0010 bib0075 bib0035 Offit (bib0005) 2007 bib0045 Corey, Nabel, Dieffenbach, Gilbert, Haynes, Johnston (bib0065) 2011; 79 Clery (bib0030) 2013 bib0050 bib0060 bib0070 Clery (10.1016/j.vaccine.2014.06.071_bib0030) 2013 Plotkin (10.1016/j.vaccine.2014.06.071_bib0015) 2011; 9 Rappuoli (10.1016/j.vaccine.2014.06.071_bib0040) 2012; 4 Weinberg (10.1016/j.vaccine.2014.06.071_bib0025) 1961; 134 Corey (10.1016/j.vaccine.2014.06.071_bib0065) 2011; 79 Offit (10.1016/j.vaccine.2014.06.071_bib0005) 2007 Rappuoli (10.1016/j.vaccine.2014.06.071_bib0020) 1997; 3 |
| References_xml | – year: 2013 ident: bib0030 article-title: Higgs theorists win physics Nobel in overtime publication-title: Science – volume: 4 start-page: 128cm4 year: 2012 ident: bib0040 article-title: ADITEC: joining forces for next-generation vaccines publication-title: Sci Transl Med – volume: 134 start-page: 161 year: 1961 end-page: 164 ident: bib0025 article-title: Impact of large-scale science on the United States publication-title: Science – ident: bib0050 – ident: bib0055 – volume: 79 start-page: 13 year: 2011 ident: bib0065 article-title: HIV-1 vaccines and adaptive trial designs publication-title: Science – volume: 9 start-page: 889 year: 2011 end-page: 893 ident: bib0015 article-title: The development of vaccines: how the past led to the future publication-title: Nat Rev Microbiol – ident: bib0075 – ident: bib0045 – ident: bib0060 – volume: 3 start-page: 374 year: 1997 end-page: 376 ident: bib0020 article-title: Rational design of vaccines publication-title: Nat Med – ident: bib0070 – ident: bib0035 – start-page: 254 year: 2007 ident: bib0005 article-title: Vaccinated – ident: bib0010 – volume: 9 start-page: 889 year: 2011 ident: 10.1016/j.vaccine.2014.06.071_bib0015 article-title: The development of vaccines: how the past led to the future publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2668 – volume: 134 start-page: 161 year: 1961 ident: 10.1016/j.vaccine.2014.06.071_bib0025 article-title: Impact of large-scale science on the United States publication-title: Science doi: 10.1126/science.134.3473.161 – volume: 3 start-page: 374 year: 1997 ident: 10.1016/j.vaccine.2014.06.071_bib0020 article-title: Rational design of vaccines publication-title: Nat Med doi: 10.1038/nm0497-374 – start-page: 254 year: 2007 ident: 10.1016/j.vaccine.2014.06.071_bib0005 – volume: 4 start-page: 128cm4 year: 2012 ident: 10.1016/j.vaccine.2014.06.071_bib0040 article-title: ADITEC: joining forces for next-generation vaccines publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3003826 – volume: 79 start-page: 13 year: 2011 ident: 10.1016/j.vaccine.2014.06.071_bib0065 article-title: HIV-1 vaccines and adaptive trial designs publication-title: Science – year: 2013 ident: 10.1016/j.vaccine.2014.06.071_bib0030 article-title: Higgs theorists win physics Nobel in overtime publication-title: Science |
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| Title | Big science for vaccine development |
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