BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

• Published in: Human molecular genetics Vol. 21; no. 5; pp. 1172 - 1183
• Main Authors: Grierson, Patrick M., Lillard, Kate, Behbehani, Gregory K., Combs, Kelly A., Bhattacharyya, Saumitri, Acharya, Samir, Groden, Joanna
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2012
• Subjects: Biological and medical sciences; Cell Line; Cell Line, Tumor; Cell Nucleolus - metabolism; Cell Nucleus - metabolism; Dactinomycin - pharmacology; DNA - chemistry; DNA - metabolism; DNA, Ribosomal - chemistry; DNA, Ribosomal - metabolism; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Humans; Molecular and cellular biology; Molecular genetics; Nucleic Acid Conformation; Protein Binding; Protein Subunits - metabolism; Recombinant Fusion Proteins - metabolism; RecQ Helicases - genetics; RecQ Helicases - metabolism; RNA Polymerase I - antagonists & inhibitors; RNA Polymerase I - metabolism; RNA, Ribosomal - genetics; Transcription, Genetic; Transcription. Transcription factor. Splicing. Rna processing; Genetics; Transcription; RNA polymerase I; Ribosomal RNA

Bloom's syndrome (BS) is an autosomal recessive disorder that is invariably characterized by severe growth retardation and cancer predisposition. The Bloom's syndrome helicase (BLM), mutations of which lead to BS, localizes to promyelocytic leukemia protein bodies and to the nucleolus of t...