Acceptability of an inactivated influenza vaccine delivered by microneedle patch: Results from a phase I clinical trial of safety, reactogenicity, and immunogenicity

• Published in: Vaccine Vol. 38; no. 45; pp. 7175 - 7181
• Main Authors: Frew, Paula M., Paine, Michele Bennett, Rouphael, Nadine, Schamel, Jay, Chung, Yunmi, Mulligan, Mark J., Prausnitz, Mark R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 21.10.2020; Elsevier Limited
• Subjects: Acceptability; Adolescent; Adult; adults; Allergy and Immunology; Antigens; Attitudes; Clinical trials; Dissolvable polymer microneedle patch; Drug delivery systems; Georgia; health care workers; Humans; Hypodermic needles; Immunogenicity; Influenza; influenza vaccination; Influenza vaccine; Influenza Vaccines; Influenza, Human - prevention & control; Injection; Intradermal vaccination; Likert scale; Medical personnel; Middle Aged; Needles; nose; Pain; Perceptions; placebos; Polls & surveys; Product development; Quantitative psychology; Reproducibility of Results; Vaccination; Vaccine acceptability; Vaccine self-administration; Vaccines; Vaccines, Inactivated - adverse effects; Young Adult; Georgia; United States > US; Dissolvable polymer microneedle patch; Intradermal vaccination; Vaccine acceptability; Vaccine self-administration; Influenza vaccine

•We evaluated acceptability of influenza vaccine by microneedle patch (MNP).•Participants’ attitudes about MNPs were influenced by experience•MNP influenza vaccination information may influence people’s vaccine acceptance.•Most participants accepted influenza MNP vaccination compared to injection.•M...