Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis

• Published in: Clinical epigenetics Vol. 14; no. 1; p. 47
• Main Authors: D’Addario, Claudio, Pucci, Mariangela, Bellia, Fabio, Girella, Antonio, Sabatucci, Annalaura, Fanti, Federico, Vismara, Matteo, Benatti, Beatrice, Ferrara, Luca, Fasciana, Federica, Celebre, Laura, Viganò, Caterina, Elli, Luca, Sergi, Manuel, Maccarrone, Mauro, Buzzelli, Valeria, Trezza, Viviana, Dell’Osso, Bernardo
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central Ltd 31.03.2022; BioMed Central
• Subjects: Analysis; Animals; DNA Methylation; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Experiments; Fatty acids; Gene Expression; Gene regulation; Genes; Genetic aspects; Genetic transcription; Humans; Hypothalamus; Laboratory animals; Mental disorders; Metabolites; Methylation; Microbiota; Microbiota (Symbiotic organisms); Molecular modelling; Obsessive compulsive disorder; Obsessive-Compulsive Disorder - genetics; Oxytocin; Prefrontal cortex; Rats; Receptors, Oxytocin - genetics; Risk factors; Saliva; Stereotyped behavior; Substance abuse treatment; Transcription; DNA methylation; Obsessive–compulsive disorder; Microbiota; Oxytocin receptor; Gene expression; Saliva

Obsessive-compulsive disorder (OCD) is a prevalent and severe clinical condition. Robust evidence suggests a gene-environment interplay in its etiopathogenesis, yet the underlying molecular clues remain only partially understood. In order to further deepen our understanding of OCD, it is essential t...