Robust Neutralizing Antibodies to SARS-CoV-2 Develop and Persist in Subjects with Diabetes and COVID-19 Pneumonia

• Published in: The journal of clinical endocrinology and metabolism Vol. 106; no. 5; pp. 1472 - 1481
• Main Authors: Dispinseri, Stefania, Lampasona, Vito, Secchi, Massimiliano, Cara, Andrea, Bazzigaluppi, Elena, Negri, Donatella, Brigatti, Cristina, Pirillo, Maria Franca, Marzinotto, Ilaria, Borghi, Martina, Rovere-Querini, Patrizia, Tresoldi, Cristina, Ciceri, Fabio, Scavini, Marina, Scarlatti, Gabriella, Piemonti, Lorenzo
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.05.2021
• Subjects: Analysis; Antibodies; Antibodies, Neutralizing - immunology; Antibody response; Bacterial pneumonia; Clinical; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - immunology; Dextrose; Diabetes; Diabetes Complications - immunology; Diabetes Complications - virology; Diabetes mellitus; Diabetics; Female; Glucose; Health aspects; Humans; Hyperglycemia; Immune response (humoral); Male; Medical research; Medicine, Experimental; Mortality; Pneumonia; Pneumonia - complications; Pneumonia - immunology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike protein; Vaccination; Vaccine development; Vaccines; Viral antibodies; China; COVID-19; survival rate; neutralizing antibodies; SARS-CoV-2; diabetes; humoral response
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/clinem/dgab055

Abstract Context Demonstrating the ability to mount a neutralizing antibody response to SARS-CoV-2 in the presence of diabetes is crucial to understand COVID-19 pathogenesis, reinfection potential, and vaccine development. Objective The aim of this study was to characterize the kinetics and durabili...