HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers

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Published inJournal of Virology Vol. 83; no. 7; pp. 3407 - 3412
Main Authors Miura, Toshiyuki, Brumme, Chanson J., Brockman, Mark A., Brumme, Zabrina L., Pereyra, Florencia, Block, Brian L., Trocha, Alicja, John, Mina, Mallal, Simon, Harrigan, P. Richard, Walker, Bruce D.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2009
American Society for Microbiology (ASM)
Subjects
Biological and medical sciences
Epitopes, T-Lymphocyte - genetics
Epitopes, T-Lymphocyte - immunology
Fundamental and applied biological sciences. Psychology
gag Gene Products, Human Immunodeficiency Virus - genetics
HIV Infections - immunology
HIV Infections - virology
HIV Long-Term Survivors
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Microbiology
Miscellaneous
Mutation, Missense - immunology
nef Gene Products, Human Immunodeficiency Virus - genetics
Pathogenesis and Immunity
Plasma - virology
pol Gene Products, Human Immunodeficiency Virus - genetics
Polymorphism, Genetic
Selection, Genetic
Viral Load
Viremia - immunology
Virology
Immunopathology
HLA-System
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Virology
Infection
Virus
Viral disease
Human immunodeficiency virus
Mutation
Online AccessGet full text
ISSN0022-538X
1098-5514
1098-5514
DOI10.1128/JVI.02459-08

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Abstract Author's Correction ( vol. 84 , p. 1212 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC, compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection.Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC, compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection.
Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC, compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection.
Author's Correction ( vol. 84 , p. 1212 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8 + T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag , pol , and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC, compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection.
Author Zabrina L. Brumme
P. Richard Harrigan
Chanson J. Brumme
Alicja Trocha
Mina John
Brian L. Block
Simon Mallal
Mark A. Brockman
Florencia Pereyra
Toshiyuki Miura
Bruce D. Walker
AuthorAffiliation Ragon Institute (formerly Partners AIDS Research Center), Massachusetts General Hospital, Charlestown, Massachusetts 02129, 1 Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, 2 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, 3 Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Australia, 4 British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, 5 Division of AIDS, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 6
AuthorAffiliation_xml – name: Ragon Institute (formerly Partners AIDS Research Center), Massachusetts General Hospital, Charlestown, Massachusetts 02129, 1 Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, 2 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, 3 Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Australia, 4 British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, 5 Division of AIDS, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 6
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Issue 7
Keywords Immunopathology
HLA-System
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Virology
Infection
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Viral disease
Human immunodeficiency virus
Mutation
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Corresponding author. Present address of Toshiyuki Miura: Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. Phone: 81-3-5449-5338. Fax: 81-3-5449-5427. E-mail: miura523@hotmail.com. Mailing address for Bruce D. Walker: Room 5212, Ragon Institute, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129. Phone: (617) 724-8332. Fax: (617) 726-4691. E-mail: bwalker@partners.org
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Snippet Author's Correction ( vol. 84 , p. 1212 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike...
Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment....
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SubjectTerms Biological and medical sciences
Epitopes, T-Lymphocyte - genetics
Epitopes, T-Lymphocyte - immunology
Fundamental and applied biological sciences. Psychology
gag Gene Products, Human Immunodeficiency Virus - genetics
HIV Infections - immunology
HIV Infections - virology
HIV Long-Term Survivors
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Microbiology
Miscellaneous
Mutation, Missense - immunology
nef Gene Products, Human Immunodeficiency Virus - genetics
Pathogenesis and Immunity
Plasma - virology
pol Gene Products, Human Immunodeficiency Virus - genetics
Polymorphism, Genetic
Selection, Genetic
Viral Load
Viremia - immunology
Virology
Title HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers
URI http://jvi.asm.org/content/83/7/3407.abstract
https://www.ncbi.nlm.nih.gov/pubmed/19153230
https://www.proquest.com/docview/21304690
https://www.proquest.com/docview/67012640
https://pubmed.ncbi.nlm.nih.gov/PMC2655568
Volume 83
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