Next Generation Mucosal Vaccine Strategy for Respiratory Pathogens

Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the potential to prevent the infection from getting established. This is different from systemic vaccination, which protects against the development of systemic symptoms. The field of mucosal vaccination has seen fewe...

Full description

Saved in:
Bibliographic Details
Published inVaccines (Basel) Vol. 11; no. 10; p. 1585
Main Authors Dotiwala, Farokh, Upadhyay, Arun K
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2023
MDPI
Subjects
Adjuvants
Analysis
Antibodies
Antigens
Cell proliferation
Chemokines
Clinical trials
COVID-19
COVID-19 vaccines
Cytotoxicity
Disease transmission
Dosage and administration
Evaluation
Expression vectors
FDA approval
Humoral immunity
Immunity
Immunoglobulin A
Immunoglobulin G
Influenza
inhaled vaccines
Lymphatic system
Lymphocytes
Lymphocytes T
Mucosal immunity
Mucosal-associated lymphoid tissue
Nucleic acids
Pandemics
Pathogenic microorganisms
Pathogens
Platforms
Respiratory diseases
respiratory infections
Respiratory syncytial virus
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Streptococcus infections
Vaccines
Whooping cough
United States
China
India
Online AccessGet full text

Cover

Abstract Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the potential to prevent the infection from getting established. This is different from systemic vaccination, which protects against the development of systemic symptoms. The field of mucosal vaccination has seen fewer technological advances compared to nucleic acid and subunit vaccine advances for injectable vaccine platforms. The advent of the next-generation adenoviral vectors has given a boost to mucosal vaccine research. Basic research into the mechanisms regulating innate and adaptive mucosal immunity and the discovery of effective and safe mucosal vaccine adjuvants will continue to improve mucosal vaccine design. The results from clinical trials of inhaled COVID-19 vaccines demonstrate their ability to induce the proliferation of cytotoxic T cells and the production of secreted IgA and IgG antibodies locally, unlike intramuscular vaccinations. However, these mucosal vaccines induce systemic immune responses at par with systemic vaccinations. This review summarizes the function of the respiratory mucosa-associated lymphoid tissue and the advantages that the adenoviral vectors provide as inhaled vaccine platforms.
AbstractList Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the potential to prevent the infection from getting established. This is different from systemic vaccination, which protects against the development of systemic symptoms. The field of mucosal vaccination has seen fewer technological advances compared to nucleic acid and subunit vaccine advances for injectable vaccine platforms. The advent of the next-generation adenoviral vectors has given a boost to mucosal vaccine research. Basic research into the mechanisms regulating innate and adaptive mucosal immunity and the discovery of effective and safe mucosal vaccine adjuvants will continue to improve mucosal vaccine design. The results from clinical trials of inhaled COVID-19 vaccines demonstrate their ability to induce the proliferation of cytotoxic T cells and the production of secreted IgA and IgG antibodies locally, unlike intramuscular vaccinations. However, these mucosal vaccines induce systemic immune responses at par with systemic vaccinations. This review summarizes the function of the respiratory mucosa-associated lymphoid tissue and the advantages that the adenoviral vectors provide as inhaled vaccine platforms.
Audience Academic
Author Upadhyay, Arun K
Dotiwala, Farokh
AuthorAffiliation Ocugen Inc., 11 Great Valley Parkway, Malvern, PA 19355, USA
AuthorAffiliation_xml – name: Ocugen Inc., 11 Great Valley Parkway, Malvern, PA 19355, USA
Author_xml – sequence: 1
  fullname: Dotiwala, Farokh
– sequence: 2
  fullname: Upadhyay, Arun K
BookMark eNptkklvFDEQRi0URBZy59gSFy4TvLS3EwoRhEhhEZu4WW53ueNRjz3Y3RHz7-NhImAi7IPtqq9eqcp1jA5iioDQM4LPGNP45a11LkQohBBMuOKP0BHFUiyYZj8O_rkfotNSlrguTZgS8gk6ZFJpoZU6Qq8_wK-puYQI2U4hxeb97FKxY_N9R2--TNUBw6bxKTefoaxDfae8aT7Z6SYNEMtT9NjbscDp_XmCvr198_Xi3eL64-XVxfn1wnHGp4WVvPeWU9Y5IZUTpNOgOOm9ghZb4TkHjqHVvbYEmJZe0LYFR_uu1ua1Yifoasftk12adQ4rmzcm2WB-G1IejM1TcCMYTW0rek86rlVLJbe96ySmzjqsOi1EZb3asdZzt4LeQaxljnvQfU8MN2ZIt4ZgUftNWCW8uCfk9HOGMplVKA7G0UZIczFUKcalbtk22fMH0mWac6y92qqoajVv2V_VYGsFIfpUE7st1JxLSXn9c0mq6uw_qrp7WAVXB8SHat8LwLsAl1MpGfyfIgk22zkyD-eI3QEMeLu6
CitedBy_id crossref_primary_10_3390_vaccines12020172
crossref_primary_10_1080_23311932_2024_2351048
crossref_primary_10_1097_MCP_0000000000001061
crossref_primary_10_3390_vaccines12060643
Cites_doi 10.1016/j.vaccine.2009.03.090
10.1021/acsami.2c17627
10.3389/fimmu.2022.860399
10.3390/polym14204450
10.1016/j.imlet.2019.10.013
10.1038/mi.2014.11
10.1016/j.celrep.2019.05.105
10.3389/fimmu.2018.02936
10.1200/JCO.2007.15.0284
10.1164/rccm.201412-2256OC
10.1016/j.jconrel.2022.05.023
10.1016/j.celrep.2018.03.027
10.1021/acs.molpharmaceut.0c01256
10.1016/j.celrep.2021.109400
10.4049/jimmunol.173.5.3310
10.1126/science.272.5258.60
10.1126/science.1214935
10.1080/14760584.2016.1213632
10.1073/pnas.2102775118
10.1084/jem.20080414
10.4110/in.2013.13.3.81
10.1371/journal.pone.0078312
10.1111/cei.13285
10.1038/s41392-023-01423-6
10.1038/s41541-022-00485-x
10.1016/j.celrep.2018.08.073
10.1074/jbc.RA118.002768
10.1016/j.lanepe.2023.100644
10.1016/j.vaccine.2007.04.081
10.3390/cancers13143387
10.4049/immunohorizons.2000067
10.1371/journal.pone.0006999
10.1016/j.biomaterials.2020.120597
10.1128/mSphere.00215-18
10.1002/(SICI)1521-2254(199909/10)1:5<360::AID-JGM54>3.0.CO;2-Q
10.1016/j.celrep.2020.107634
10.1016/j.vaccine.2011.10.058
10.1128/JVI.00768-11
10.1089/dna.1993.12.771
10.1101/2022.03.08.22271816
10.1016/j.immuni.2006.02.015
10.4049/jimmunol.1701010
10.1038/nature11522
10.1371/journal.pone.0033736
10.7150/thno.70853
10.1016/j.jconrel.2021.01.014
10.1016/j.virol.2006.08.006
10.1016/S0140-6736(22)02644-7
10.1053/j.seminhematol.2022.02.004
10.1016/B978-0-12-396548-6.00008-1
10.3389/fimmu.2022.1063679
10.1007/s00253-012-4575-1
10.1371/journal.ppat.1003875
10.1016/j.isci.2021.103379
10.1016/j.vaccine.2004.11.010
10.1016/j.ebiom.2022.103841
10.1111/j.1462-5822.2011.01609.x
10.1097/JOM.0000000000000879
10.1016/S1473-3099(23)00350-X
10.4049/jimmunol.173.3.1978
10.3389/fimmu.2020.611337
10.1182/blood.2022017696
10.1016/j.biologicals.2017.10.004
10.1056/NEJMoa030595
10.1038/s41577-020-00479-7
10.1038/ncomms13916
10.1177/21501327211007393
10.1038/mi.2017.62
10.3389/fimmu.2020.583077
10.3389/fimmu.2019.01323
10.4049/jimmunol.166.5.3451
10.1016/j.ijpharm.2021.121180
10.1038/mi.2011.39
10.1038/s41467-021-26499-y
10.1038/s41541-023-00717-8
10.3389/fimmu.2019.01126
10.1189/jlb.0313180
10.1038/nri3739
10.1128/JVI.00927-06
10.1016/j.chom.2017.12.010
10.1056/NEJMc2210813
10.1038/s41577-021-00662-4
10.1146/annurev-immunol-020711-074950
10.1016/j.cell.2022.03.024
10.1038/mi.2016.28
10.1111/jth.15485
10.1093/cid/civ617
10.1186/s12929-020-00695-2
10.1186/s12985-021-01672-3
10.1007/s00018-018-2976-8
10.3389/fimmu.2022.849515
10.4161/hv.27147
10.3390/vaccines9080850
10.1016/j.vaccine.2018.04.066
10.1182/blood-2006-06-032524
10.1007/s13238-012-2927-3
10.1038/s41392-023-01408-5
10.1111/imcb.12306
10.1016/B978-012491543-5/50011-5
10.1073/pnas.1720930115
10.1093/cid/cix869
10.3389/fmicb.2017.00900
10.1038/nri3442
10.1038/s41541-022-00503-y
10.1126/sciimmunol.abc5500
10.1159/000355628
10.1038/ni.3045
10.1038/ncomms7588
10.5603/ARM.a2021.0036
10.1038/s41598-021-03931-3
10.1080/22221751.2022.2132881
10.1002/JLB.4MR0220-446R
10.1016/j.addr.2016.06.013
10.1021/acsinfecdis.9b00109
10.1016/j.immuni.2014.12.007
10.1016/j.addr.2013.05.002
10.1038/s41385-018-0080-x
10.1038/s41467-019-08659-3
10.1016/j.cell.2020.08.026
10.1016/j.addr.2013.04.001
10.1126/science.abo2523
10.1038/nri2496
10.1002/anie.201501461
10.1016/j.vaccine.2011.09.010
10.1016/j.xcrm.2021.100230
10.1586/erv.10.172
10.7554/eLife.68662
10.1038/s41467-021-27063-4
10.1016/j.cell.2020.04.042
10.4049/jimmunol.181.7.4955
10.3390/immuno2040036
10.1080/21645515.2015.1009345
10.1186/1742-2094-11-14
10.1128/JVI.00207-09
10.1016/S1473-3099(22)00510-2
10.4049/jimmunol.1200402
10.1073/pnas.89.15.6901
10.1080/21645515.2015.1114195
10.1016/j.celrep.2019.08.004
10.3389/fimmu.2021.614115
10.1126/scitranslmed.3004888
10.1016/j.vaccine.2009.02.025
10.1016/B978-0-12-381300-8.00007-1
10.1038/s41385-020-0309-3
10.1126/science.aaa8205
10.1016/j.chom.2020.12.010
10.1128/JVI.03085-12
10.1161/CIRCRESAHA.119.315800
10.1038/nri2322
10.4049/jimmunol.2100029
10.1093/infdis/jiac129
10.1016/j.chom.2022.11.016
10.4049/jimmunol.175.5.2793
10.1128/CMR.00090-16
10.1056/NEJMoa2109908
10.1038/s41591-022-02162-x
10.1038/s41577-021-00583-2
10.1038/s41385-018-0109-1
10.1159/000049504
10.1016/S1473-3099(20)30274-7
10.1111/imr.13118
10.1073/pnas.2202069119
10.1080/21505594.2022.2068489
10.1073/pnas.1620910114
10.1016/j.jaip.2022.10.002
10.3389/fimmu.2020.577823
10.1038/s41541-019-0129-1
10.1371/journal.pone.0041144
10.1038/mtm.2016.30
10.1021/acsbiomaterials.6b00418
10.1182/blood.2021014712
10.3389/fimmu.2020.00353
10.1126/sciadv.abl8213
10.3389/fimmu.2021.809244
10.1016/S2213-2600(23)00049-8
10.7554/eLife.56098
10.3390/vaccines10111906
10.1056/NEJMc2105869
10.1016/j.jobb.2022.12.002
10.4049/jimmunol.179.5.2690
10.1084/jem.161.1.198
10.1016/j.autrev.2012.10.011
10.1016/j.biotechadv.2015.05.010
10.1016/j.vaccine.2020.02.056
10.1038/mi.2007.6
10.1172/JCI170682
10.1084/jem.20090858
10.1038/ni.3745
10.1038/s41577-023-00853-1
10.1146/annurev-immunol-102119-073855
10.1128/jvi.69.2.1339-1343.1995
10.1161/CIRCULATIONAHA.116.020838
10.1016/j.celrep.2021.109401
10.1038/nrmicro2384
10.1016/j.virol.2015.03.032
10.1038/nri.2016.117
10.4049/jimmunol.2100107
10.1126/scitranslmed.abd2223
10.1016/j.nano.2017.05.011
10.3389/fimmu.2021.672143
10.1016/j.celrep.2018.03.072
10.3389/fbioe.2020.558349
10.3390/vaccines3020320
10.1098/rstb.2015.0142
10.1016/j.immuni.2022.04.013
10.3390/nano11051119
10.3389/fimmu.2014.00408
10.1002/hsr2.428
10.4161/hv.27449
10.1038/s41385-021-00470-y
10.1093/infdis/jiz321
10.2174/1381612822666160915161302
10.1371/journal.pone.0051351
10.1111/j.1574-695X.2007.00359.x
10.1128/CVI.00688-13
10.1186/s12951-017-0319-9
10.1111/j.1600-065X.2010.00970.x
10.1038/s41423-023-01017-w
10.3389/fimmu.2022.1039194
ContentType Journal Article
Copyright COPYRIGHT 2023 MDPI AG
2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 by the authors. 2023
Copyright_xml – notice: COPYRIGHT 2023 MDPI AG
– notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 by the authors. 2023
DBID AAYXX
CITATION
3V.
7T7
7XB
8FD
8FE
8FH
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
COVID
DWQXO
FR3
GNUQQ
GUQSH
HCIFZ
LK8
M2O
M7P
MBDVC
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.3390/vaccines11101585
DatabaseName CrossRef
ProQuest Central (Corporate)
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (purchase pre-March 2016)
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
Coronavirus Research Database
ProQuest Central
Engineering Research Database
ProQuest Central Student
Research Library Prep
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
Biological Sciences
ProQuest research library
Biological Science Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
Technology Research Database
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Research Library
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest One Academic Eastern Edition
Coronavirus Research Database
Biological Science Database
ProQuest SciTech Collection
Biotechnology and BioEngineering Abstracts
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef
MEDLINE - Academic

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 2076-393X
ExternalDocumentID oai_doaj_org_article_92a46df1b5984275adcb702cac08b966
A772533971
10_3390_vaccines11101585
GeographicLocations United States
China
India
GeographicLocations_xml – name: United States
– name: China
– name: India
GrantInformation_xml – fundername: Ocugen Inc.
GroupedDBID 3V.
53G
5VS
8FE
8FH
8G5
AADQD
AAHBH
AAYXX
ABUWG
ADBBV
AFKRA
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
CCPQU
CITATION
DIK
DWQXO
GNUQQ
GROUPED_DOAJ
GUQSH
HCIFZ
HYE
IAO
IHR
ITC
KQ8
LK8
M2O
M48
M7P
MODMG
M~E
OK1
PGMZT
PIMPY
PQQKQ
PROAC
RIG
RNS
RPM
7T7
7XB
8FD
8FK
C1K
COVID
FR3
MBDVC
P64
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c535t-a75dfa523bc678c61b9e851df8e40a6f55e50e49d9a1e397f6244ec2db585f983
IEDL.DBID RPM
ISSN 2076-393X
IngestDate Tue Oct 22 15:16:12 EDT 2024
Tue Sep 17 21:29:39 EDT 2024
Fri Oct 25 05:57:44 EDT 2024
Thu Oct 10 19:37:40 EDT 2024
Wed Apr 10 18:05:54 EDT 2024
Tue Nov 12 23:40:00 EST 2024
Thu Sep 26 17:08:59 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c535t-a75dfa523bc678c61b9e851df8e40a6f55e50e49d9a1e397f6244ec2db585f983
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0002-1675-1744
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611113/
PMID 37896988
PQID 2882849543
PQPubID 2032320
ParticipantIDs doaj_primary_oai_doaj_org_article_92a46df1b5984275adcb702cac08b966
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10611113
proquest_miscellaneous_2883579436
proquest_journals_2882849543
gale_infotracmisc_A772533971
gale_infotracacademiconefile_A772533971
crossref_primary_10_3390_vaccines11101585
PublicationCentury 2000
PublicationDate 2023-10-01
PublicationDateYYYYMMDD 2023-10-01
PublicationDate_xml – month: 10
  year: 2023
  text: 2023-10-01
  day: 01
PublicationDecade 2020
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle Vaccines (Basel)
PublicationYear 2023
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References ref_137
ref_136
Russell (ref_116) 2020; 11
Wang (ref_193) 2023; 8
Kimura (ref_25) 2019; 10
ref_138
Meeusen (ref_41) 2011; 29
Smith (ref_183) 2014; 10
Li (ref_152) 2022; 226
Lin (ref_185) 2022; 14
Mistry (ref_1) 2021; 12
Sohrabi (ref_99) 2020; 11
Yun (ref_122) 2021; 331
Im (ref_77) 2013; 87
Perrone (ref_117) 2009; 83
Gallichan (ref_119) 2001; 166
Logerot (ref_88) 2021; 12
Singh (ref_14) 2023; 8
Baker (ref_33) 2014; 5
Bull (ref_18) 2019; 12
Jaensson (ref_31) 2008; 205
ref_128
Sterlin (ref_49) 2021; 13
Hu (ref_141) 2017; 13
Brichkina (ref_112) 2023; 20
ref_123
Mohamed (ref_184) 2018; 51
Fleige (ref_32) 2018; 23
Chandrashekar (ref_10) 2022; 185
Iwasaki (ref_188) 2017; 17
Rossato (ref_54) 2013; 12
Woodland (ref_68) 2009; 9
Ku (ref_154) 2021; 29
Parker (ref_39) 2020; 9
Baker (ref_220) 2021; 7
Wang (ref_144) 2021; 118
McKeage (ref_161) 2011; 71
Joseph (ref_34) 2022; 2
ref_150
Seavey (ref_85) 2009; 27
Li (ref_7) 2020; 217
Antoine (ref_23) 2008; 26
ref_155
Schrum (ref_96) 2018; 200
Pasetti (ref_37) 2011; 239
Netea (ref_90) 2020; 181
Zhou (ref_46) 2011; 85
Blok (ref_108) 2020; 70
Walk (ref_107) 2019; 10
Travieso (ref_126) 2022; 7
Lin (ref_130) 2015; 11
Gao (ref_201) 2023; 133
Jahnmatz (ref_20) 2020; 20
Mahendra (ref_202) 2021; 89
Corthesy (ref_47) 2006; 80
ref_83
Randall (ref_24) 2010; 107
Niess (ref_28) 2006; 24
Prill (ref_203) 2021; 4
Cines (ref_215) 2023; 141
ref_87
Chen (ref_134) 2022; 12
Su (ref_72) 2016; 12
ref_146
Holtzman (ref_195) 2014; 14
Bekkering (ref_89) 2021; 39
Corr (ref_27) 2008; 52
Moorlag (ref_110) 2020; 31
Strugnell (ref_36) 2010; 8
Lavelle (ref_71) 2022; 22
Renegar (ref_204) 2004; 173
Cichon (ref_217) 1999; 1
Mao (ref_192) 2022; 378
Zhao (ref_170) 2021; 36
Yankauckas (ref_120) 1993; 12
Preiss (ref_133) 2015; 3
Bentley (ref_2) 2019; 196
Boyton (ref_22) 2023; 29
Cerutti (ref_35) 2008; 8
Afkhami (ref_211) 2016; 3
Forbes (ref_118) 2008; 181
Lartey (ref_17) 2020; 221
Groh (ref_105) 2020; 127
Christensen (ref_80) 2017; 10
Arts (ref_106) 2018; 23
Sunagar (ref_4) 2022; 13
Varga (ref_65) 2018; 24
Ifrim (ref_98) 2014; 21
Hameed (ref_124) 2022; 7
Hong (ref_171) 2012; 30
Lane (ref_213) 2022; 387
Ohtsuka (ref_156) 2021; 24
Mueller (ref_143) 2020; 38
Lund (ref_94) 2015; 61
Ameratunga (ref_56) 2023; 11
Burt (ref_132) 2011; 10
Kamada (ref_103) 2018; 115
Hassan (ref_13) 2020; 183
Jong (ref_82) 2022; 208
Sandoval (ref_67) 2013; 5
Lee (ref_166) 2022; 13
Stary (ref_74) 2015; 348
Garcia (ref_129) 2016; 22
Woof (ref_40) 2011; 4
Bricker (ref_11) 2021; 36
Greinacher (ref_221) 2022; 59
Wu (ref_66) 2014; 95
Pollard (ref_142) 2021; 21
Taylor (ref_51) 1985; 161
Love (ref_223) 2021; 12
James (ref_189) 2022; 15
Youn (ref_180) 2007; 25
Xu (ref_6) 2021; 609
Othman (ref_216) 2021; 19
ref_222
Chentoufi (ref_209) 2022; 13
Americo (ref_151) 2022; 119
Rieckmann (ref_95) 2017; 46
Collaborators (ref_16) 2022; 22
Li (ref_210) 2023; 23
Masopust (ref_63) 2013; 13
Atalis (ref_164) 2022; 347
Whitsett (ref_196) 2015; 16
Sabbaghi (ref_168) 2021; 18
Ribes (ref_113) 2014; 11
Wright (ref_48) 2006; 356
Nicolai (ref_219) 2022; 140
Zimmermann (ref_199) 2018; 36
Randall (ref_92) 2014; 7
Minor (ref_125) 2015; 479–480
ref_15
Bradley (ref_200) 2019; 28
Bernstein (ref_76) 2019; 4
Othman (ref_218) 2007; 109
Shim (ref_86) 2013; 13
Luangrath (ref_59) 2021; 5
Cordeiro (ref_127) 2015; 33
Cheng (ref_173) 2021; 12
Raemdonck (ref_135) 2013; 65
Muir (ref_212) 2021; 384
Allen (ref_81) 2018; 11
Xu (ref_42) 2019; 5
Stobart (ref_153) 2016; 7
Bakkari (ref_163) 2021; 18
ref_26
Bekkering (ref_100) 2016; 134
Arima (ref_140) 2013; 65
Wheeler (ref_162) 2001; 126
Habibi (ref_205) 2015; 191
Mutsch (ref_175) 2004; 350
Keech (ref_19) 2023; 401
Sun (ref_157) 2021; 12
Morens (ref_145) 2023; 31
Mettelman (ref_190) 2022; 55
Masopust (ref_61) 2010; 207
Kleinnijenhuis (ref_93) 2014; 6
Kurhade (ref_21) 2023; 29
Wang (ref_159) 2020; 11
Didierlaurent (ref_160) 2017; 16
Butcher (ref_57) 1996; 272
Rotrosen (ref_70) 2023; 23
Lycke (ref_38) 2017; 10
Poehling (ref_147) 2018; 66
Clements (ref_177) 2018; 3
Lapuente (ref_194) 2021; 12
Contractor (ref_29) 2007; 179
Schenkel (ref_58) 2014; 41
Cirovic (ref_109) 2019; 28
Hoft (ref_8) 2011; 13
Zhang (ref_179) 2019; 10
Lipsitch (ref_9) 2022; 22
ref_174
ref_176
Casey (ref_62) 2012; 188
Ribelles (ref_78) 2013; 97
Ariotti (ref_60) 2012; 114
Pavord (ref_214) 2021; 385
ref_182
Zhong (ref_79) 2022; 11
Brisse (ref_114) 2020; 11
Medzhitov (ref_187) 2012; 335
Maurer (ref_43) 2018; 23
Zhang (ref_121) 2017; 3
Stothers (ref_111) 2021; 207
ref_169
Jeyanathan (ref_224) 2022; 13
Wang (ref_139) 2015; 54
Tang (ref_149) 2023; 11
Mazanec (ref_44) 1992; 89
Schlimgen (ref_208) 2016; 58
Anthony (ref_64) 2021; 10
ref_167
Freytag (ref_158) 2005; 23
Fraser (ref_181) 2009; 27
Hong (ref_97) 2015; 6
Macpherson (ref_50) 2008; 1
Favre (ref_53) 2005; 175
Mazanec (ref_45) 1995; 69
Mades (ref_191) 2021; 11
Ulas (ref_104) 2017; 18
Eskandari (ref_131) 2017; 110–111
Wang (ref_115) 2023; 8
Conejero (ref_207) 2018; 9
Hassan (ref_12) 2021; 2
Xing (ref_91) 2020; 108
ref_198
Gribonika (ref_84) 2022; 7
Hjelm (ref_172) 2014; 10
Russell (ref_55) 2017; 30
Hansen (ref_197) 2019; 76
Eriksson (ref_178) 2004; 173
Xiong (ref_73) 2012; 3
Cleophas (ref_101) 2017; 114
Davis (ref_52) 2020; 98
Cartwright (ref_148) 2021; 14
ref_186
Sanders (ref_206) 2022; 309
Merad (ref_30) 2013; 31
ref_3
Shin (ref_75) 2012; 491
Keating (ref_102) 2020; 116
Hassert (ref_69) 2022; 13
ref_5
Tandon (ref_165) 2018; 293
References_xml – volume: 27
  start-page: 3766
  year: 2009
  ident: ref_181
  article-title: Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2009.03.090
  contributor:
    fullname: Fraser
– volume: 14
  start-page: 52691
  year: 2022
  ident: ref_185
  article-title: Enhanced Immune Responses to Mucosa by Functionalized Chitosan-Based Composite Nanoparticles as a Vaccine Adjuvant for Intranasal Delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.2c17627
  contributor:
    fullname: Lin
– volume: 13
  start-page: 860399
  year: 2022
  ident: ref_224
  article-title: Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.860399
  contributor:
    fullname: Jeyanathan
– ident: ref_222
  doi: 10.3390/polym14204450
– volume: 217
  start-page: 116
  year: 2020
  ident: ref_7
  article-title: Mucosal vaccines: Strategies and challenges
  publication-title: Immunol. Lett.
  doi: 10.1016/j.imlet.2019.10.013
  contributor:
    fullname: Li
– volume: 7
  start-page: 455
  year: 2014
  ident: ref_92
  article-title: The development and function of mucosal lymphoid tissues: A balancing act with micro-organisms
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2014.11
  contributor:
    fullname: Randall
– volume: 28
  start-page: 245
  year: 2019
  ident: ref_200
  article-title: Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.05.105
  contributor:
    fullname: Bradley
– volume: 9
  start-page: 2936
  year: 2018
  ident: ref_207
  article-title: Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02936
  contributor:
    fullname: Conejero
– volume: 26
  start-page: 4410
  year: 2008
  ident: ref_23
  article-title: Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2007.15.0284
  contributor:
    fullname: Antoine
– volume: 191
  start-page: 1040
  year: 2015
  ident: ref_205
  article-title: Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201412-2256OC
  contributor:
    fullname: Habibi
– volume: 116
  start-page: 317
  year: 2020
  ident: ref_102
  article-title: Aldosterone induces trained immunity: The role of fatty acid synthesis
  publication-title: Cardiovasc. Res.
  contributor:
    fullname: Keating
– volume: 70
  start-page: 455
  year: 2020
  ident: ref_108
  article-title: Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guerin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial
  publication-title: Clin. Infect. Dis.
  contributor:
    fullname: Blok
– volume: 347
  start-page: 476
  year: 2022
  ident: ref_164
  article-title: Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.05.023
  contributor:
    fullname: Atalis
– volume: 23
  start-page: 90
  year: 2018
  ident: ref_43
  article-title: Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.03.027
  contributor:
    fullname: Maurer
– volume: 18
  start-page: 2233
  year: 2021
  ident: ref_163
  article-title: Toll-like Receptor-4 (TLR4) Agonist-Based Intranasal Nanovaccine Delivery System for Inducing Systemic and Mucosal Immunity
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.0c01256
  contributor:
    fullname: Bakkari
– volume: 36
  start-page: 109400
  year: 2021
  ident: ref_11
  article-title: A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109400
  contributor:
    fullname: Bricker
– volume: 173
  start-page: 3310
  year: 2004
  ident: ref_178
  article-title: The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.173.5.3310
  contributor:
    fullname: Eriksson
– volume: 272
  start-page: 60
  year: 1996
  ident: ref_57
  article-title: Lymphocyte homing and homeostasis
  publication-title: Science
  doi: 10.1126/science.272.5258.60
  contributor:
    fullname: Butcher
– volume: 335
  start-page: 936
  year: 2012
  ident: ref_187
  article-title: Disease tolerance as a defense strategy
  publication-title: Science
  doi: 10.1126/science.1214935
  contributor:
    fullname: Medzhitov
– volume: 16
  start-page: 55
  year: 2017
  ident: ref_160
  article-title: Adjuvant system AS01: Helping to overcome the challenges of modern vaccines
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2016.1213632
  contributor:
    fullname: Didierlaurent
– volume: 118
  start-page: e2102775118
  year: 2021
  ident: ref_144
  article-title: Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2102775118
  contributor:
    fullname: Wang
– volume: 205
  start-page: 2139
  year: 2008
  ident: ref_31
  article-title: Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20080414
  contributor:
    fullname: Jaensson
– volume: 13
  start-page: 81
  year: 2013
  ident: ref_86
  article-title: Sublingual delivery of vaccines for the induction of mucosal immunity
  publication-title: Immune Netw.
  doi: 10.4110/in.2013.13.3.81
  contributor:
    fullname: Shim
– ident: ref_174
  doi: 10.1371/journal.pone.0078312
– volume: 196
  start-page: 205
  year: 2019
  ident: ref_2
  article-title: Mucosal vaccines and technology
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/cei.13285
  contributor:
    fullname: Bentley
– volume: 8
  start-page: 167
  year: 2023
  ident: ref_193
  article-title: Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants
  publication-title: Signal Transduct. Target. Ther.
  doi: 10.1038/s41392-023-01423-6
  contributor:
    fullname: Wang
– volume: 7
  start-page: 71
  year: 2022
  ident: ref_124
  article-title: Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-022-00485-x
  contributor:
    fullname: Hameed
– volume: 24
  start-page: 3374
  year: 2018
  ident: ref_65
  article-title: Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.073
  contributor:
    fullname: Varga
– volume: 293
  start-page: 19874
  year: 2018
  ident: ref_165
  article-title: A TLR4-derived non-cytotoxic, self-assembling peptide functions as a vaccine adjuvant in mice
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA118.002768
  contributor:
    fullname: Tandon
– volume: 29
  start-page: 100644
  year: 2023
  ident: ref_22
  article-title: Redirected vaccine imprinting by co-administration of COVID-19 and influenza vaccines
  publication-title: Lancet Reg. Health Eur.
  doi: 10.1016/j.lanepe.2023.100644
  contributor:
    fullname: Boyton
– volume: 25
  start-page: 5189
  year: 2007
  ident: ref_180
  article-title: A single intranasal immunization with inactivated influenza virus and α-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2007.04.081
  contributor:
    fullname: Youn
– ident: ref_138
  doi: 10.3390/cancers13143387
– volume: 5
  start-page: 59
  year: 2021
  ident: ref_59
  article-title: Tissue-Resident Memory T Cells in the Lungs Protect against Acute Respiratory Syncytial Virus Infection
  publication-title: Immunohorizons
  doi: 10.4049/immunohorizons.2000067
  contributor:
    fullname: Luangrath
– ident: ref_176
  doi: 10.1371/journal.pone.0006999
– ident: ref_137
  doi: 10.1016/j.biomaterials.2020.120597
– volume: 3
  start-page: e00215-18
  year: 2018
  ident: ref_177
  article-title: The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT
  publication-title: mSphere
  doi: 10.1128/mSphere.00215-18
  contributor:
    fullname: Clements
– volume: 1
  start-page: 360
  year: 1999
  ident: ref_217
  article-title: Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits
  publication-title: J. Gene Med.
  doi: 10.1002/(SICI)1521-2254(199909/10)1:5<360::AID-JGM54>3.0.CO;2-Q
  contributor:
    fullname: Cichon
– volume: 31
  start-page: 107634
  year: 2020
  ident: ref_110
  article-title: β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.107634
  contributor:
    fullname: Moorlag
– volume: 30
  start-page: 466
  year: 2012
  ident: ref_171
  article-title: Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.10.058
  contributor:
    fullname: Hong
– volume: 85
  start-page: 11090
  year: 2011
  ident: ref_46
  article-title: Matrix protein-specific IgA antibody inhibits measles virus replication by intracellular neutralization
  publication-title: J. Virol.
  doi: 10.1128/JVI.00768-11
  contributor:
    fullname: Zhou
– volume: 12
  start-page: 771
  year: 1993
  ident: ref_120
  article-title: Long-term anti-nucleoprotein cellular and humoral immunity is induced by intramuscular injection of plasmid DNA containing NP gene
  publication-title: DNA Cell Biol.
  doi: 10.1089/dna.1993.12.771
  contributor:
    fullname: Yankauckas
– ident: ref_15
  doi: 10.1101/2022.03.08.22271816
– volume: 24
  start-page: 623
  year: 2006
  ident: ref_28
  article-title: CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer’s patches
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.02.015
  contributor:
    fullname: Niess
– volume: 200
  start-page: 1243
  year: 2018
  ident: ref_96
  article-title: Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1701010
  contributor:
    fullname: Schrum
– volume: 491
  start-page: 463
  year: 2012
  ident: ref_75
  article-title: A vaccine strategy that protects against genital herpes by establishing local memory T cells
  publication-title: Nature
  doi: 10.1038/nature11522
  contributor:
    fullname: Shin
– ident: ref_87
  doi: 10.1371/journal.pone.0033736
– volume: 12
  start-page: 4081
  year: 2022
  ident: ref_134
  article-title: Advances in the polymeric delivery of nucleic acid vaccines
  publication-title: Theranostics
  doi: 10.7150/thno.70853
  contributor:
    fullname: Chen
– volume: 331
  start-page: 121
  year: 2021
  ident: ref_122
  article-title: Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2021.01.014
  contributor:
    fullname: Yun
– volume: 356
  start-page: 165
  year: 2006
  ident: ref_48
  article-title: Immunoglobulin A antibodies against internal HIV-1 proteins neutralize HIV-1 replication inside epithelial cells
  publication-title: Virology
  doi: 10.1016/j.virol.2006.08.006
  contributor:
    fullname: Wright
– volume: 401
  start-page: 843
  year: 2023
  ident: ref_19
  article-title: Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus-diphtheria-acellular pertussis vaccine: A randomised, double-blind, phase 2b trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)02644-7
  contributor:
    fullname: Keech
– volume: 59
  start-page: 97
  year: 2022
  ident: ref_221
  article-title: Pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT)
  publication-title: Semin. Hematol.
  doi: 10.1053/j.seminhematol.2022.02.004
  contributor:
    fullname: Greinacher
– volume: 114
  start-page: 203
  year: 2012
  ident: ref_60
  article-title: Behavior and function of tissue-resident memory T cells
  publication-title: Adv. Immunol.
  doi: 10.1016/B978-0-12-396548-6.00008-1
  contributor:
    fullname: Ariotti
– volume: 13
  start-page: 1063679
  year: 2022
  ident: ref_4
  article-title: Preclinical evaluation of safety and immunogenicity of a primary series intranasal COVID-19 vaccine candidate (BBV154) and humoral immunogenicity evaluation of a heterologous prime-boost strategy with COVAXIN (BBV152)
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.1063679
  contributor:
    fullname: Sunagar
– volume: 97
  start-page: 1231
  year: 2013
  ident: ref_78
  article-title: Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-012-4575-1
  contributor:
    fullname: Ribelles
– ident: ref_83
  doi: 10.1371/journal.ppat.1003875
– volume: 24
  start-page: 103379
  year: 2021
  ident: ref_156
  article-title: Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2
  publication-title: iScience
  doi: 10.1016/j.isci.2021.103379
  contributor:
    fullname: Ohtsuka
– volume: 23
  start-page: 1804
  year: 2005
  ident: ref_158
  article-title: Mucosal adjuvants
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2004.11.010
  contributor:
    fullname: Freytag
– ident: ref_5
  doi: 10.1016/j.ebiom.2022.103841
– volume: 13
  start-page: 934
  year: 2011
  ident: ref_8
  article-title: Optimizing vaccine development
  publication-title: Cell. Microbiol.
  doi: 10.1111/j.1462-5822.2011.01609.x
  contributor:
    fullname: Hoft
– volume: 58
  start-page: 1159
  year: 2016
  ident: ref_208
  article-title: Risks Associated With Lentiviral Vector Exposures and Prevention Strategies
  publication-title: J. Occup. Environ. Med.
  doi: 10.1097/JOM.0000000000000879
  contributor:
    fullname: Schlimgen
– volume: 23
  start-page: 1143
  year: 2023
  ident: ref_210
  article-title: Safety, immunogenicity and protection of heterologous boost with an aerosolised Ad5-nCoV after two-dose inactivated COVID-19 vaccines in adults: A multicentre, open-label phase 3 trial
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(23)00350-X
  contributor:
    fullname: Li
– volume: 173
  start-page: 1978
  year: 2004
  ident: ref_204
  article-title: Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.173.3.1978
  contributor:
    fullname: Renegar
– volume: 11
  start-page: 611337
  year: 2020
  ident: ref_116
  article-title: Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.611337
  contributor:
    fullname: Russell
– volume: 141
  start-page: 1659
  year: 2023
  ident: ref_215
  article-title: Vaccine-induced immune thrombotic thrombocytopenia
  publication-title: Blood
  doi: 10.1182/blood.2022017696
  contributor:
    fullname: Cines
– volume: 51
  start-page: 46
  year: 2018
  ident: ref_184
  article-title: Preparation and immunological evaluation of inactivated avian influenza virus vaccine encapsulated in chitosan nanoparticles
  publication-title: Biologicals
  doi: 10.1016/j.biologicals.2017.10.004
  contributor:
    fullname: Mohamed
– volume: 350
  start-page: 896
  year: 2004
  ident: ref_175
  article-title: Use of the inactivated intranasal influenza vaccine and the risk of Bell’s palsy in Switzerland
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa030595
  contributor:
    fullname: Mutsch
– volume: 21
  start-page: 83
  year: 2021
  ident: ref_142
  article-title: A guide to vaccinology: From basic principles to new developments
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-020-00479-7
  contributor:
    fullname: Pollard
– volume: 7
  start-page: 13916
  year: 2016
  ident: ref_153
  article-title: A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13916
  contributor:
    fullname: Stobart
– volume: 12
  start-page: 21501327211007393
  year: 2021
  ident: ref_223
  article-title: Considering Needle Phobia among Adult Patients During Mass COVID-19 Vaccinations
  publication-title: J. Prim. Care Community Health
  doi: 10.1177/21501327211007393
  contributor:
    fullname: Love
– volume: 10
  start-page: 1361
  year: 2017
  ident: ref_38
  article-title: The regulation of gut mucosal IgA B-cell responses: Recent developments
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2017.62
  contributor:
    fullname: Lycke
– volume: 11
  start-page: 583077
  year: 2020
  ident: ref_114
  article-title: Emerging Concepts and Technologies in Vaccine Development
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.583077
  contributor:
    fullname: Brisse
– volume: 10
  start-page: 1323
  year: 2019
  ident: ref_25
  article-title: Airway M Cells Arise in the Lower Airway Due to RANKL Signaling and Reside in the Bronchiolar Epithelium Associated With iBALT in Murine Models of Respiratory Disease
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.01323
  contributor:
    fullname: Kimura
– volume: 166
  start-page: 3451
  year: 2001
  ident: ref_119
  article-title: Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.166.5.3451
  contributor:
    fullname: Gallichan
– volume: 609
  start-page: 121180
  year: 2021
  ident: ref_6
  article-title: Intranasal vaccine: Factors to consider in research and development
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2021.121180
  contributor:
    fullname: Xu
– volume: 4
  start-page: 590
  year: 2011
  ident: ref_40
  article-title: Structure and function relationships in IgA
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2011.39
  contributor:
    fullname: Woof
– volume: 12
  start-page: 6197
  year: 2021
  ident: ref_157
  article-title: A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26499-y
  contributor:
    fullname: Sun
– volume: 8
  start-page: 125
  year: 2023
  ident: ref_14
  article-title: Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®)
  publication-title: npj Vaccines
  doi: 10.1038/s41541-023-00717-8
  contributor:
    fullname: Singh
– volume: 10
  start-page: 1126
  year: 2019
  ident: ref_179
  article-title: alpha-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.01126
  contributor:
    fullname: Zhang
– volume: 95
  start-page: 215
  year: 2014
  ident: ref_66
  article-title: Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0313180
  contributor:
    fullname: Wu
– volume: 14
  start-page: 686
  year: 2014
  ident: ref_195
  article-title: The role of airway epithelial cells and innate immune cells in chronic respiratory disease
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3739
  contributor:
    fullname: Holtzman
– volume: 80
  start-page: 10692
  year: 2006
  ident: ref_47
  article-title: Rotavirus anti-VP6 secretory immunoglobulin A contributes to protection via intracellular neutralization but not via immune exclusion
  publication-title: J. Virol.
  doi: 10.1128/JVI.00927-06
  contributor:
    fullname: Corthesy
– volume: 23
  start-page: 89
  year: 2018
  ident: ref_106
  article-title: BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.12.010
  contributor:
    fullname: Arts
– volume: 387
  start-page: 1431
  year: 2022
  ident: ref_213
  article-title: Vaccine-Induced Immune Thrombocytopenia and Thrombosis after the Sputnik V Vaccine
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2210813
  contributor:
    fullname: Lane
– volume: 22
  start-page: 57
  year: 2022
  ident: ref_9
  article-title: SARS-CoV-2 breakthrough infections in vaccinated individuals: Measurement, causes and impact
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-021-00662-4
  contributor:
    fullname: Lipsitch
– volume: 31
  start-page: 563
  year: 2013
  ident: ref_30
  article-title: The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-020711-074950
  contributor:
    fullname: Merad
– volume: 185
  start-page: 1549
  year: 2022
  ident: ref_10
  article-title: Vaccine protection against the SARS-CoV-2 Omicron variant in macaques
  publication-title: Cell
  doi: 10.1016/j.cell.2022.03.024
  contributor:
    fullname: Chandrashekar
– volume: 10
  start-page: 260
  year: 2017
  ident: ref_80
  article-title: Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2016.28
  contributor:
    fullname: Christensen
– volume: 19
  start-page: 2845
  year: 2021
  ident: ref_216
  article-title: To clot or not to clot? Ad is the question-Insights on mechanisms related to vaccine-induced thrombotic thrombocytopenia
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/jth.15485
  contributor:
    fullname: Othman
– volume: 61
  start-page: 1504
  year: 2015
  ident: ref_94
  article-title: The effect of oral polio vaccine at birth on infant mortality: A randomized trial
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/civ617
  contributor:
    fullname: Lund
– ident: ref_123
  doi: 10.1186/s12929-020-00695-2
– volume: 18
  start-page: 201
  year: 2021
  ident: ref_168
  article-title: A formulated poly (I:C)/CCL21 as an effective mucosal adjuvant for gamma-irradiated influenza vaccine
  publication-title: Virol. J.
  doi: 10.1186/s12985-021-01672-3
  contributor:
    fullname: Sabbaghi
– volume: 76
  start-page: 1041
  year: 2019
  ident: ref_197
  article-title: The inflammatory function of human IgA
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-018-2976-8
  contributor:
    fullname: Hansen
– volume: 13
  start-page: 849515
  year: 2022
  ident: ref_209
  article-title: Combinatorial Herpes Simplex Vaccine Strategies: From Bedside to Bench and Back
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.849515
  contributor:
    fullname: Chentoufi
– volume: 10
  start-page: 410
  year: 2014
  ident: ref_172
  article-title: TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines
  publication-title: Hum. Vaccines Immunother.
  doi: 10.4161/hv.27147
  contributor:
    fullname: Hjelm
– ident: ref_155
  doi: 10.3390/vaccines9080850
– volume: 36
  start-page: 4433
  year: 2018
  ident: ref_199
  article-title: The influence of the intestinal microbiome on vaccine responses
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2018.04.066
  contributor:
    fullname: Zimmermann
– volume: 109
  start-page: 2832
  year: 2007
  ident: ref_218
  article-title: Adenovirus-induced thrombocytopenia: The role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance
  publication-title: Blood
  doi: 10.1182/blood-2006-06-032524
  contributor:
    fullname: Othman
– volume: 3
  start-page: 571
  year: 2012
  ident: ref_73
  article-title: CCR10 and its ligands in regulation of epithelial immunity and diseases
  publication-title: Protein Cell
  doi: 10.1007/s13238-012-2927-3
  contributor:
    fullname: Xiong
– volume: 8
  start-page: 149
  year: 2023
  ident: ref_115
  article-title: Viral vectored vaccines: Design, development, preventive and therapeutic applications in human diseases
  publication-title: Signal Transduct. Target. Ther.
  doi: 10.1038/s41392-023-01408-5
  contributor:
    fullname: Wang
– volume: 98
  start-page: 276
  year: 2020
  ident: ref_52
  article-title: Serum IgA Fc effector functions in infectious disease and cancer
  publication-title: Immunol. Cell Biol.
  doi: 10.1111/imcb.12306
  contributor:
    fullname: Davis
– ident: ref_26
  doi: 10.1016/B978-012491543-5/50011-5
– volume: 115
  start-page: E9162
  year: 2018
  ident: ref_103
  article-title: Interferon stimulation creates chromatin marks and establishes transcriptional memory
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1720930115
  contributor:
    fullname: Kamada
– volume: 66
  start-page: 665
  year: 2018
  ident: ref_147
  article-title: 2015–2016 Vaccine Effectiveness of Live Attenuated and Inactivated Influenza Vaccines in Children in the United States
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix869
  contributor:
    fullname: Poehling
– ident: ref_198
  doi: 10.3389/fmicb.2017.00900
– volume: 13
  start-page: 309
  year: 2013
  ident: ref_63
  article-title: The integration of T cell migration, differentiation and function
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3442
  contributor:
    fullname: Masopust
– ident: ref_150
– volume: 7
  start-page: 75
  year: 2022
  ident: ref_126
  article-title: The use of viral vectors in vaccine development
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-022-00503-y
  contributor:
    fullname: Travieso
– volume: 7
  start-page: eabc5500
  year: 2022
  ident: ref_84
  article-title: Peyer’s patch TH17 cells are dispensable for gut IgA responses to oral immunization
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.abc5500
  contributor:
    fullname: Gribonika
– volume: 6
  start-page: 152
  year: 2014
  ident: ref_93
  article-title: Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity
  publication-title: J. Innate Immun.
  doi: 10.1159/000355628
  contributor:
    fullname: Kleinnijenhuis
– volume: 16
  start-page: 27
  year: 2015
  ident: ref_196
  article-title: Respiratory epithelial cells orchestrate pulmonary innate immunity
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3045
  contributor:
    fullname: Whitsett
– volume: 6
  start-page: 6588
  year: 2015
  ident: ref_97
  article-title: Trained immunity in newborn infants of HBV-infected mothers
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7588
  contributor:
    fullname: Hong
– volume: 89
  start-page: 135
  year: 2021
  ident: ref_202
  article-title: Predictors of mortality in patients with severe COVID-19 pneumonia—A retrospective study
  publication-title: Adv. Respir. Med.
  doi: 10.5603/ARM.a2021.0036
  contributor:
    fullname: Mahendra
– volume: 11
  start-page: 24448
  year: 2021
  ident: ref_191
  article-title: Detection of persistent SARS-CoV-2 IgG antibodies in oral mucosal fluid and upper respiratory tract specimens following COVID-19 mRNA vaccination
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-03931-3
  contributor:
    fullname: Mades
– volume: 11
  start-page: 2689
  year: 2022
  ident: ref_79
  article-title: Heterologous booster with inhaled adenovirus vector COVID-19 vaccine generated more neutralizing antibodies against different SARS-CoV-2 variants
  publication-title: Emerg. Microbes Infect.
  doi: 10.1080/22221751.2022.2132881
  contributor:
    fullname: Zhong
– volume: 108
  start-page: 825
  year: 2020
  ident: ref_91
  article-title: Innate immune memory of tissue-resident macrophages and trained innate immunity: Re-vamping vaccine concept and strategies
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/JLB.4MR0220-446R
  contributor:
    fullname: Xing
– volume: 110–111
  start-page: 169
  year: 2017
  ident: ref_131
  article-title: Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.06.013
  contributor:
    fullname: Eskandari
– volume: 5
  start-page: 1570
  year: 2019
  ident: ref_42
  article-title: Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria
  publication-title: ACS Infect. Dis.
  doi: 10.1021/acsinfecdis.9b00109
  contributor:
    fullname: Xu
– volume: 41
  start-page: 886
  year: 2014
  ident: ref_58
  article-title: Tissue-resident memory T cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.12.007
  contributor:
    fullname: Schenkel
– volume: 65
  start-page: 1123
  year: 2013
  ident: ref_135
  article-title: Polysaccharide-based nucleic acid nanoformulations
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2013.05.002
  contributor:
    fullname: Raemdonck
– volume: 11
  start-page: 1763
  year: 2018
  ident: ref_81
  article-title: Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T(RM) cells
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-018-0080-x
  contributor:
    fullname: Allen
– volume: 10
  start-page: 874
  year: 2019
  ident: ref_107
  article-title: Outcomes of controlled human malaria infection after BCG vaccination
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08659-3
  contributor:
    fullname: Walk
– volume: 183
  start-page: 169
  year: 2020
  ident: ref_13
  article-title: A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.026
  contributor:
    fullname: Hassan
– volume: 46
  start-page: 695
  year: 2017
  ident: ref_95
  article-title: Vaccinations against smallpox and tuberculosis are associated with better long-term survival: A Danish case-cohort study 1971–2010
  publication-title: Int. J. Epidemiol.
  contributor:
    fullname: Rieckmann
– volume: 65
  start-page: 1204
  year: 2013
  ident: ref_140
  article-title: Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2013.04.001
  contributor:
    fullname: Arima
– volume: 378
  start-page: eabo2523
  year: 2022
  ident: ref_192
  article-title: Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
  publication-title: Science
  doi: 10.1126/science.abo2523
  contributor:
    fullname: Mao
– volume: 9
  start-page: 153
  year: 2009
  ident: ref_68
  article-title: Migration, maintenance and recall of memory T cells in peripheral tissues
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2496
  contributor:
    fullname: Woodland
– volume: 54
  start-page: 11647
  year: 2015
  ident: ref_139
  article-title: Self-Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.201501461
  contributor:
    fullname: Wang
– volume: 29
  start-page: 8506
  year: 2011
  ident: ref_41
  article-title: Exploiting mucosal surfaces for the development of mucosal vaccines
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.09.010
  contributor:
    fullname: Meeusen
– volume: 2
  start-page: 100230
  year: 2021
  ident: ref_12
  article-title: A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
  publication-title: Cell Rep. Med.
  doi: 10.1016/j.xcrm.2021.100230
  contributor:
    fullname: Hassan
– volume: 10
  start-page: 365
  year: 2011
  ident: ref_132
  article-title: Proteosome-adjuvanted intranasal influenza vaccines: Advantages, progress and future considerations
  publication-title: Expert Rev. Vaccines
  doi: 10.1586/erv.10.172
  contributor:
    fullname: Burt
– volume: 10
  start-page: e68662
  year: 2021
  ident: ref_64
  article-title: Protective function and durability of mouse lymph node-resident memory CD8+ T cells
  publication-title: eLife
  doi: 10.7554/eLife.68662
  contributor:
    fullname: Anthony
– volume: 12
  start-page: 6871
  year: 2021
  ident: ref_194
  article-title: Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27063-4
  contributor:
    fullname: Lapuente
– volume: 181
  start-page: 969
  year: 2020
  ident: ref_90
  article-title: Trained Immunity: A Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection
  publication-title: Cell
  doi: 10.1016/j.cell.2020.04.042
  contributor:
    fullname: Netea
– volume: 181
  start-page: 4955
  year: 2008
  ident: ref_118
  article-title: Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.181.7.4955
  contributor:
    fullname: Forbes
– volume: 2
  start-page: 571
  year: 2022
  ident: ref_34
  article-title: Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections
  publication-title: Immuno
  doi: 10.3390/immuno2040036
  contributor:
    fullname: Joseph
– volume: 11
  start-page: 650
  year: 2015
  ident: ref_130
  article-title: Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases
  publication-title: Hum. Vaccines Immunother.
  doi: 10.1080/21645515.2015.1009345
  contributor:
    fullname: Lin
– volume: 11
  start-page: 14
  year: 2014
  ident: ref_113
  article-title: Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection
  publication-title: J. Neuroinflamm.
  doi: 10.1186/1742-2094-11-14
  contributor:
    fullname: Ribes
– volume: 83
  start-page: 5726
  year: 2009
  ident: ref_117
  article-title: Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge
  publication-title: J. Virol.
  doi: 10.1128/JVI.00207-09
  contributor:
    fullname: Perrone
– volume: 22
  start-page: 1626
  year: 2022
  ident: ref_16
  article-title: Age-sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: Results from the Global Burden of Disease Study 2019
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(22)00510-2
  contributor:
    fullname: Collaborators
– volume: 188
  start-page: 4866
  year: 2012
  ident: ref_62
  article-title: Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1200402
  contributor:
    fullname: Casey
– volume: 89
  start-page: 6901
  year: 1992
  ident: ref_44
  article-title: Intracellular neutralization of virus by immunoglobulin A antibodies
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.89.15.6901
  contributor:
    fullname: Mazanec
– volume: 12
  start-page: 1070
  year: 2016
  ident: ref_72
  article-title: Induction of mucosal immunity through systemic immunization: Phantom or reality?
  publication-title: Hum. Vaccines Immunother.
  doi: 10.1080/21645515.2015.1114195
  contributor:
    fullname: Su
– volume: 28
  start-page: 2659
  year: 2019
  ident: ref_109
  article-title: β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: A Crucial Role for IL-32
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.08.004
  contributor:
    fullname: Cirovic
– volume: 12
  start-page: 614115
  year: 2021
  ident: ref_88
  article-title: IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.614115
  contributor:
    fullname: Logerot
– volume: 5
  start-page: 172ra20
  year: 2013
  ident: ref_67
  article-title: Mucosal imprinting of vaccine-induced CD8+ T cells is crucial to inhibit the growth of mucosal tumors
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3004888
  contributor:
    fullname: Sandoval
– volume: 27
  start-page: 2342
  year: 2009
  ident: ref_85
  article-title: Estradiol-induced vaginal mucus inhibits antigen penetration and CD8+ T cell priming in response to intravaginal immunization
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2009.02.025
  contributor:
    fullname: Seavey
– volume: 107
  start-page: 187
  year: 2010
  ident: ref_24
  article-title: Bronchus-associated lymphoid tissue (BALT) structure and function
  publication-title: Adv. Immunol.
  doi: 10.1016/B978-0-12-381300-8.00007-1
  contributor:
    fullname: Randall
– volume: 14
  start-page: 92
  year: 2021
  ident: ref_148
  article-title: Long-term maintenance of lung resident memory T cells is mediated by persistent antigen
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-020-0309-3
  contributor:
    fullname: Cartwright
– volume: 348
  start-page: aaa8205
  year: 2015
  ident: ref_74
  article-title: VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
  publication-title: Science
  doi: 10.1126/science.aaa8205
  contributor:
    fullname: Stary
– volume: 29
  start-page: 236
  year: 2021
  ident: ref_154
  article-title: Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2020.12.010
  contributor:
    fullname: Ku
– volume: 87
  start-page: 4751
  year: 2013
  ident: ref_77
  article-title: An attenuated Listeria monocytogenes vector primes more potent simian immunodeficiency virus-specific mucosal immunity than DNA vaccines in mice
  publication-title: J. Virol.
  doi: 10.1128/JVI.03085-12
  contributor:
    fullname: Im
– volume: 127
  start-page: 269
  year: 2020
  ident: ref_105
  article-title: Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315800
  contributor:
    fullname: Groh
– volume: 8
  start-page: 421
  year: 2008
  ident: ref_35
  article-title: The regulation of IgA class switching
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2322
  contributor:
    fullname: Cerutti
– volume: 208
  start-page: 407
  year: 2022
  ident: ref_82
  article-title: Mucosal Vaccination with Cyclic Dinucleotide Adjuvants Induces Effective T Cell Homing and IL-17-Dependent Protection against Mycobacterium tuberculosis Infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.2100029
  contributor:
    fullname: Jong
– volume: 226
  start-page: 585
  year: 2022
  ident: ref_152
  article-title: Horizontal Transmission of Cytomegalovirus in a Rhesus Model Despite High-Level, Vaccine-Elicited Neutralizing Antibody and T-Cell Responses
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiac129
  contributor:
    fullname: Li
– volume: 31
  start-page: 146
  year: 2023
  ident: ref_145
  article-title: Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2022.11.016
  contributor:
    fullname: Morens
– volume: 175
  start-page: 2793
  year: 2005
  ident: ref_53
  article-title: Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.175.5.2793
  contributor:
    fullname: Favre
– volume: 30
  start-page: 481
  year: 2017
  ident: ref_55
  article-title: The Human Immune Response to Respiratory Syncytial Virus Infection
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00090-16
  contributor:
    fullname: Russell
– volume: 385
  start-page: 1680
  year: 2021
  ident: ref_214
  article-title: Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2109908
  contributor:
    fullname: Pavord
– volume: 29
  start-page: 344
  year: 2023
  ident: ref_21
  article-title: Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-02162-x
  contributor:
    fullname: Kurhade
– volume: 22
  start-page: 236
  year: 2022
  ident: ref_71
  article-title: Mucosal vaccines—Fortifying the frontiers
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-021-00583-2
  contributor:
    fullname: Lavelle
– volume: 12
  start-page: 555
  year: 2019
  ident: ref_18
  article-title: Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-018-0109-1
  contributor:
    fullname: Bull
– volume: 126
  start-page: 135
  year: 2001
  ident: ref_162
  article-title: A Th1-inducing adjuvant, MPL, enhances antibody profiles in experimental animals suggesting it has the potential to improve the efficacy of allergy vaccines
  publication-title: Int. Arch. Allergy Immunol.
  doi: 10.1159/000049504
  contributor:
    fullname: Wheeler
– volume: 20
  start-page: 1290
  year: 2020
  ident: ref_20
  article-title: Safety and immunogenicity of the live attenuated intranasal pertussis vaccine BPZE1: A phase 1b, double-blind, randomised, placebo-controlled dose-escalation study
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(20)30274-7
  contributor:
    fullname: Jahnmatz
– volume: 309
  start-page: 75
  year: 2022
  ident: ref_206
  article-title: Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS-CoV-2 infection
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.13118
  contributor:
    fullname: Sanders
– volume: 119
  start-page: e2202069119
  year: 2022
  ident: ref_151
  article-title: Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2202069119
  contributor:
    fullname: Americo
– volume: 13
  start-page: 808
  year: 2022
  ident: ref_166
  article-title: Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection against Mycobacterium avium infection but is ineffective as an adjunct to antibiotic treatment in chronic disease
  publication-title: Virulence
  doi: 10.1080/21505594.2022.2068489
  contributor:
    fullname: Lee
– volume: 114
  start-page: 5485
  year: 2017
  ident: ref_101
  article-title: Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1620910114
  contributor:
    fullname: Cleophas
– volume: 11
  start-page: 181
  year: 2023
  ident: ref_56
  article-title: Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19
  publication-title: J. Allergy Clin. Immunol. Pract.
  doi: 10.1016/j.jaip.2022.10.002
  contributor:
    fullname: Ameratunga
– volume: 11
  start-page: 577823
  year: 2020
  ident: ref_159
  article-title: MPL Adjuvant Contains Competitive Antagonists of Human TLR4
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.577823
  contributor:
    fullname: Wang
– volume: 4
  start-page: 33
  year: 2019
  ident: ref_76
  article-title: Successful application of prime and pull strategy for a therapeutic HSV vaccine
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-019-0129-1
  contributor:
    fullname: Bernstein
– ident: ref_167
  doi: 10.1371/journal.pone.0041144
– volume: 3
  start-page: 16030
  year: 2016
  ident: ref_211
  article-title: Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens
  publication-title: Mol. Ther. Methods Clin. Dev.
  doi: 10.1038/mtm.2016.30
  contributor:
    fullname: Afkhami
– volume: 3
  start-page: 108
  year: 2017
  ident: ref_121
  article-title: Polymers for DNA Vaccine Delivery
  publication-title: ACS Biomater. Sci. Eng.
  doi: 10.1021/acsbiomaterials.6b00418
  contributor:
    fullname: Zhang
– volume: 140
  start-page: 478
  year: 2022
  ident: ref_219
  article-title: Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration
  publication-title: Blood
  doi: 10.1182/blood.2021014712
  contributor:
    fullname: Nicolai
– volume: 11
  start-page: 353
  year: 2020
  ident: ref_99
  article-title: LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.00353
  contributor:
    fullname: Sohrabi
– volume: 7
  start-page: eabl8213
  year: 2021
  ident: ref_220
  article-title: ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abl8213
  contributor:
    fullname: Baker
– volume: 12
  start-page: 809244
  year: 2021
  ident: ref_1
  article-title: SARS-CoV-2 Variants, Vaccines, and Host Immunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.809244
  contributor:
    fullname: Mistry
– volume: 11
  start-page: 613
  year: 2023
  ident: ref_149
  article-title: Safety and immunogenicity of aerosolised Ad5-nCoV, intramuscular Ad5-nCoV, or inactivated COVID-19 vaccine CoronaVac given as the second booster following three doses of CoronaVac: A multicentre, open-label, phase 4, randomised trial
  publication-title: Lancet Respir. Med.
  doi: 10.1016/S2213-2600(23)00049-8
  contributor:
    fullname: Tang
– volume: 9
  start-page: e56098
  year: 2020
  ident: ref_39
  article-title: The structures of secretory and dimeric immunoglobulin A
  publication-title: eLife
  doi: 10.7554/eLife.56098
  contributor:
    fullname: Parker
– ident: ref_182
  doi: 10.3390/vaccines10111906
– volume: 384
  start-page: 1964
  year: 2021
  ident: ref_212
  article-title: Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2105869
  contributor:
    fullname: Muir
– ident: ref_3
  doi: 10.1016/j.jobb.2022.12.002
– volume: 179
  start-page: 2690
  year: 2007
  ident: ref_29
  article-title: Cutting edge: Peyer’s patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: Possible role for IL-10, TGFbeta, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.5.2690
  contributor:
    fullname: Contractor
– volume: 161
  start-page: 198
  year: 1985
  ident: ref_51
  article-title: Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.161.1.198
  contributor:
    fullname: Taylor
– volume: 12
  start-page: 666
  year: 2013
  ident: ref_54
  article-title: Anti-inflammatory role of the IgA Fc receptor (CD89): From autoimmunity to therapeutic perspectives
  publication-title: Autoimmun. Rev.
  doi: 10.1016/j.autrev.2012.10.011
  contributor:
    fullname: Rossato
– volume: 33
  start-page: 1279
  year: 2015
  ident: ref_127
  article-title: Nanoengineering of vaccines using natural polysaccharides
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2015.05.010
  contributor:
    fullname: Cordeiro
– volume: 38
  start-page: 2943
  year: 2020
  ident: ref_143
  article-title: A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primates
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.02.056
  contributor:
    fullname: Mueller
– volume: 1
  start-page: 11
  year: 2008
  ident: ref_50
  article-title: The immune geography of IgA induction and function
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2007.6
  contributor:
    fullname: Macpherson
– volume: 133
  start-page: e170682
  year: 2023
  ident: ref_201
  article-title: Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI170682
  contributor:
    fullname: Gao
– volume: 207
  start-page: 553
  year: 2010
  ident: ref_61
  article-title: Dynamic T cell migration program provides resident memory within intestinal epithelium
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20090858
  contributor:
    fullname: Masopust
– volume: 18
  start-page: 622
  year: 2017
  ident: ref_104
  article-title: S100-alarmin-induced innate immune programming protects newborn infants from sepsis
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3745
  contributor:
    fullname: Ulas
– volume: 23
  start-page: 655
  year: 2023
  ident: ref_70
  article-title: Assessing the generation of tissue resident memory T cells by vaccines
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-023-00853-1
  contributor:
    fullname: Rotrosen
– volume: 39
  start-page: 667
  year: 2021
  ident: ref_89
  article-title: Trained Immunity: Reprogramming Innate Immunity in Health and Disease
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-102119-073855
  contributor:
    fullname: Bekkering
– volume: 69
  start-page: 1339
  year: 1995
  ident: ref_45
  article-title: Intracellular neutralization of influenza virus by immunoglobulin A anti-hemagglutinin monoclonal antibodies
  publication-title: J. Virol.
  doi: 10.1128/jvi.69.2.1339-1343.1995
  contributor:
    fullname: Mazanec
– volume: 134
  start-page: 611
  year: 2016
  ident: ref_100
  article-title: Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.020838
  contributor:
    fullname: Bekkering
– volume: 36
  start-page: 109401
  year: 2021
  ident: ref_170
  article-title: A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109401
  contributor:
    fullname: Zhao
– volume: 8
  start-page: 656
  year: 2010
  ident: ref_36
  article-title: The role of secretory antibodies in infection immunity
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2384
  contributor:
    fullname: Strugnell
– volume: 479–480
  start-page: 379
  year: 2015
  ident: ref_125
  article-title: Live attenuated vaccines: Historical successes and current challenges
  publication-title: Virology
  doi: 10.1016/j.virol.2015.03.032
  contributor:
    fullname: Minor
– volume: 17
  start-page: 7
  year: 2017
  ident: ref_188
  article-title: Early local immune defences in the respiratory tract
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2016.117
  contributor:
    fullname: Iwasaki
– volume: 207
  start-page: 2785
  year: 2021
  ident: ref_111
  article-title: β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.2100107
  contributor:
    fullname: Stothers
– volume: 13
  start-page: eabd2223
  year: 2021
  ident: ref_49
  article-title: IgA dominates the early neutralizing antibody response to SARS-CoV-2
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.abd2223
  contributor:
    fullname: Sterlin
– volume: 13
  start-page: 2189
  year: 2017
  ident: ref_141
  article-title: Polyethylene glycol modified PAMAM dendrimer delivery of kartogenin to induce chondrogenic differentiation of mesenchymal stem cells
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2017.05.011
  contributor:
    fullname: Hu
– volume: 71
  start-page: 465
  year: 2011
  ident: ref_161
  article-title: AS04-adjuvanted human papillomavirus (HPV) types 16 and 18 vaccine (Cervarix(R)): A review of its use in the prevention of premalignant cervical lesions and cervical cancer causally related to certain oncogenic HPV types
  publication-title: Drugs
  contributor:
    fullname: McKeage
– volume: 12
  start-page: 672143
  year: 2021
  ident: ref_173
  article-title: TLR9- and CD40-Targeting Vaccination Promotes Human B Cell Maturation and IgG Induction via pDC-Dependent Mechanisms in Humanized Mice
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.672143
  contributor:
    fullname: Cheng
– volume: 23
  start-page: 783
  year: 2018
  ident: ref_32
  article-title: Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.03.072
  contributor:
    fullname: Fleige
– ident: ref_186
  doi: 10.3389/fbioe.2020.558349
– volume: 3
  start-page: 320
  year: 2015
  ident: ref_133
  article-title: Vaccine Adjuvants: From 1920 to 2015 and Beyond
  publication-title: Vaccines
  doi: 10.3390/vaccines3020320
  contributor:
    fullname: Preiss
– ident: ref_146
  doi: 10.1098/rstb.2015.0142
– volume: 55
  start-page: 749
  year: 2022
  ident: ref_190
  article-title: Mucosal immune responses to infection and vaccination in the respiratory tract
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.04.013
  contributor:
    fullname: Mettelman
– ident: ref_136
  doi: 10.3390/nano11051119
– volume: 5
  start-page: 408
  year: 2014
  ident: ref_33
  article-title: The Role of FcRn in Antigen Presentation
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00408
  contributor:
    fullname: Baker
– volume: 4
  start-page: e428
  year: 2021
  ident: ref_203
  article-title: Respiratory syncytial virus-associated deaths in the United States according to death certificate data, 2005 to 2016
  publication-title: Health Sci. Rep.
  doi: 10.1002/hsr2.428
  contributor:
    fullname: Prill
– volume: 10
  start-page: 797
  year: 2014
  ident: ref_183
  article-title: Chitosan: A promising safe and immune-enhancing adjuvant for intranasal vaccines
  publication-title: Hum. Vaccines Immunother.
  doi: 10.4161/hv.27449
  contributor:
    fullname: Smith
– volume: 15
  start-page: 531
  year: 2022
  ident: ref_189
  article-title: Redefining intestinal immunity with single-cell transcriptomics
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-021-00470-y
  contributor:
    fullname: James
– volume: 221
  start-page: 21
  year: 2020
  ident: ref_17
  article-title: Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiz321
  contributor:
    fullname: Lartey
– volume: 22
  start-page: 6294
  year: 2016
  ident: ref_129
  article-title: An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/1381612822666160915161302
  contributor:
    fullname: Garcia
– ident: ref_169
  doi: 10.1371/journal.pone.0051351
– volume: 52
  start-page: 2
  year: 2008
  ident: ref_27
  article-title: M-cells: Origin, morphology and role in mucosal immunity and microbial pathogenesis
  publication-title: FEMS Immunol. Med. Microbiol.
  doi: 10.1111/j.1574-695X.2007.00359.x
  contributor:
    fullname: Corr
– volume: 21
  start-page: 534
  year: 2014
  ident: ref_98
  article-title: Trained immunity or tolerance: Opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors
  publication-title: Clin. Vaccine Immunol.
  doi: 10.1128/CVI.00688-13
  contributor:
    fullname: Ifrim
– ident: ref_128
  doi: 10.1186/s12951-017-0319-9
– volume: 239
  start-page: 125
  year: 2011
  ident: ref_37
  article-title: Immunology of gut mucosal vaccines
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2010.00970.x
  contributor:
    fullname: Pasetti
– volume: 20
  start-page: 864
  year: 2023
  ident: ref_112
  article-title: A novel role for mitochondrial fission in macrophages: Trained innate immunity induced by beta-glucan
  publication-title: Cell Mol. Immunol.
  doi: 10.1038/s41423-023-01017-w
  contributor:
    fullname: Brichkina
– volume: 13
  start-page: 1039194
  year: 2022
  ident: ref_69
  article-title: Tissue resident memory T cells—A new benchmark for the induction of vaccine-induced mucosal immunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.1039194
  contributor:
    fullname: Hassert
SSID ssj0000913867
Score 2.360256
SecondaryResourceType review_article
Snippet Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the potential to prevent the infection from getting established. This is...
SourceID doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 1585
SubjectTerms Adjuvants
Analysis
Antibodies
Antigens
Cell proliferation
Chemokines
Clinical trials
COVID-19
COVID-19 vaccines
Cytotoxicity
Disease transmission
Dosage and administration
Evaluation
Expression vectors
FDA approval
Humoral immunity
Immunity
Immunoglobulin A
Immunoglobulin G
Influenza
inhaled vaccines
Lymphatic system
Lymphocytes
Lymphocytes T
Mucosal immunity
Mucosal-associated lymphoid tissue
Nucleic acids
Pandemics
Pathogenic microorganisms
Pathogens
Platforms
Respiratory diseases
respiratory infections
Respiratory syncytial virus
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Streptococcus infections
Vaccines
Whooping cough
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fS90wFA7DJ1_G_DHs_EGE4RhYbNOkaR5VFBGUy1DxLSRpwvbSO3avwv3v_dJU76172Mv62KQlPacn5_vIyRdCvjLPSi_qkAtvQFBC4RBzXObG16VFunS-iruRb27rq3t-_SgeV476ijVhSR44Ge5EMcPrNpRWqIYzKUzrrCyYM65oLLB6P_sWaoVM9XOwKqumlmldsgKvP3k2Lq5UzxDbyIDx6OSVPNTL9f89Kb8vlFzJPJefyMcBMtLTNNQN8sF3m-RokjSnF8f0brmFanZMj-hkqUa92CJnt5h-aVKXjk6gN7FGHe97SEOlgz7tggK-0h_LlXc6ATic4v-abZP7y4u786t8ODghd6IS89xI0QYDimkdcpGD1ZUHsmpD43lh6iCEF4XnqlWm9AAkoUaS9461FoYJqqk-k7Vu2vkdQo01hTQlt84pLqRTjQkuKOBMx6QJdUa-v5pR_076GBq8Ippcvzd5Rs6ind_6RWXr_gb8rQd_63_5OyPfopd0jD_YB_fTNgIMNypZ6VPQBUBYJcuM7I16Im7cuPnVz3qI25lmIBwNOCOvMnL41hyfjLVonZ8-9X0qEXX1MJZm9H-Mvmzc0v362Wt3RwaOq_ryP2yxS9YZMFeqLdwja_M_T34fGGluD_pweAGVzxJ1
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3BTtwwELXa5dJLRWmrpqWVkSqqSkQkjh3Hp4qtQAiJ1QpBxc2yHbv0klCyIO3fdybx7hIqkWPsJM7Y43ljj98Q8pV5lntRhlR4Aw5KyBzoHJep8WVuwVw6X-Bp5PNZeXrFz67FdVxw62JY5WpO7CfqunW4Rn7IAApWgOZ58eP2b4pZo3B3NabQeEm2GHgK2YRsTY9n84v1KguyXlalHPYnC_DvDx-Mwx3rDnQcLCGmUH5kj3ra_v8n56cBk48s0Mk2eR2hIz0a-voNeeGbHbI_H7inlwf0cnOUqjug-3S-YaVeviXTGUzDdGCZxs6g5xirDu_7NTSVRp7aJQUYSy82O_B0DiCxhXHWvSNXJ8eXP0_TmEAhdaIQi9RIUQcDrqZ1YJMcSF95QFh1qDzPTBmE8CLzXNXK5B6ASSjB2HvHaguCCaoq3pNJ0zb-A6HGmkyanFvnFBfSqcoEFxTgTcekCWVCvq_EqG8HngwN_gWKXD8VeUKmKOd1PWS47m-0d791VBitmOFlHXIrVMWZFKZ2VmbMGZdVFny0hHzDXtKohyAfuD8cJ4DmIqOVPgK3AaCsknlCdkc1QX_cuHjVzzrqb6c3oy0he-tifBJj0hrf3vd1CoH8etCWajQ-Rn82Lmn-3PQc3uiJw1V8fP7rn8grzG8_RA_uksni7t5_BhS0sF_iUP8HlvcLRw
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9UwFD7oBNmLzF9YnRJBJsKqbZqfDyKbOIawcZFd2VtI0mQK0qv33o3d_34nbe9q557sY5OU9OScnO8jyReANzTQMnARcx4sEpRYeIw5JnMbROkwXfpQpdPIR8ficMq-nvLT4Xh0b8DFrdQu3Sc1nf96f_ln9QkD_mNinEjZP1xYnxahFxi2mNwUvwv3KEOenjby9WC_nZd1WSkhu7XKWxtuwv1KKi10ew_LkKZaNf9_5-yb-yj_SkwHW_CgR5Rkr3OBh3AnNI9gZ9JJUq92yclwwmqxS3bIZBCrXj2G_WOcnUknPp3GiBylLez4ve9dr0kvX7siiG7Jt2FhnkwQO87Q_RZPYHrw5eTzYd7fq5B7XvFlbiWvo0UG6jymKo-DogMCrzqqwAorIueBF4HpWtsyIF6JAjFA8LR2aKOoVfUUNppZE54Bsc4W0pbMea8Zl14rG33UCEM9lTaKDN6tzWh-d_IZBmlHsr65af0M9pOdr-sl4ev2xWx-Zvo4MppaJupYOq4Vo5Lb2jtZUG99oRxStwzeplEyyWHQPvi-O2WA3U1CV2YP2QQiXC3LDLZHNTGs_Lh4Pc5m7ZWGIh9RSClZlcHr6-LUMm1Va8LsvK1T8SS7h31RI_8Y_dm4pPn5o5X2TgQdn-r5_zd9AZsUgVi34XAbNpbz8_ASgdPSvWrj4QrEOBuj
  priority: 102
  providerName: Scholars Portal
Title Next Generation Mucosal Vaccine Strategy for Respiratory Pathogens
URI https://www.proquest.com/docview/2882849543
https://search.proquest.com/docview/2883579436
https://pubmed.ncbi.nlm.nih.gov/PMC10611113
https://doaj.org/article/92a46df1b5984275adcb702cac08b966
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJeuml9EndposKJaUQZ21Zz2N2m5AWdmtCEnIzkiy1gcYbspvC_vuOZDsbp7debLAkI49mNPNZo08IfSKO5I5xnzKnAaD4zILNUZFqx3MD7tK6IuxGns35yTn9fskutxDv98LEpH1rrg6a39cHzdWvmFt5c23HfZ7YuJxNA4wJR6SPt9E2aOgDjB7nX5UXkot2TbIATD_-o21YpV5CG_B-MpxWUwipuIrnrWzcUWTt_3dufpwv-cABHT9Hz7rIER-2PXyBtlzzEu2VLfX0eh-fbXZSLffxHi43pNTrV2gyh1kYtyTTYSzwLKSqw_su2l7jjqZ2jSGKxaebBXhcQoy4ADVbvkbnx0dn05O0Oz8htaxgq1QLVnsNSNNYcEkWhK8cBFi1l45mmnvGHMscVbXSuYO4xHPw9c6S2oCMvJLFG7TTLBr3FmFtdCZ0To21ijJhldTeegXhpiVCe56gL70Yq5uWJqMCeBGkXz2WfoImQc739QLBdXywuP1ZdcNcKaIpr31umJKUCKZra0RGrLaZNADREvQ5jFIVzBDkA8_b3QTQ3UBoVR0CaoBIVok8QbuDmmA-dljcj3PVme-yIoA7JEBHWiTo431xaBlS0hq3uIt1Chbo9aAvcqAfgy8bloBGRwrvXoPf_X_T9-gpgYCrTSzcRTur2zv3AQKklRmhJ5OjeXkK9-mPi29fR_FHA1xnVI6irfwFaNkYIw
link.rule.ids 230,315,730,783,787,867,888,2109,2228,21400,24330,27936,27937,33756,33757,38528,43817,43907,53804,53806,74630,74740
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagPcAFUR4iUKiRUBFSo-Zhx_EJdatWC3RXq2qLerNsxy5cktJskfbfM5N4d5tWIsfYSZyxx_ONPf6GkE-Zy1LHCx9zp8FB8YkFnWMi1q5IDZhL63I8jTyZFuML9v2SX4YFtzaEVa7mxG6irhqLa-SHGUDBEtA8y79e_4kxaxTuroYUGo_JNlJVgfO1PTqZzs7XqyzIelkWot-fzMG_P_yrLe5Yt6DjYAkxhfIde9TR9j-cnO8HTN6xQKfPybMAHelR39c75JGrX5D9Wc89vTyg881RqvaA7tPZhpV6-ZKMpjAN055lGjuDTjBWHd73s28qDTy1Swowlp5vduDpDEBiA-OsfUUuTk_mx-M4JFCILc_5ItaCV16Dq2ks2CQL0pcOEFblS8cSXXjOHU8ck5XUqQNg4gsw9s5mlQHBeFnmr8lW3dTuDaHa6ETolBlrJePCylJ76yXgTZsJ7YuIfFmJUV33PBkK_AsUubov8oiMUM7reshw3d1obq5UUBglM82KyqeGy5JlguvKGpFkVtukNOCjReQz9pJCPQT5wP3-OAE0Fxmt1BG4DQBlpUgjsjuoCfpjh8WrflZBf1u1GW0R-bguxicxJq12zW1XJ-fIrwdtKQfjY_Bnw5L696-Owxs9cbjyt___-h55Mp5PztTZt-mPd-Qp5rrvIwl3ydbi5ta9B0S0MB_CsP8Hbg8OQQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLagkxAviKsIDDASGkJa1FzsOH5CK6wal1XRtKG9WbZjD16SsXRI_feck7jtMiT6GDupcy4-34mPPxPyLnNZ6njhY-40JCg-seBzTMTaFamBcGldjruRjxfF0Rn7es7PQ_1TF8oq13NiP1HXrcVv5NMMoGAJaJ7lUx_KIqrP84-Xv2M8QQpXWsNxGnfJjmBFnkzIzuxwUZ1svrggA2ZZiGGtModcf_pHW1y97sDfISricco3YlNP4f_vRH27ePJGNJo_JA8CjKQHg94fkTuueUz2qoGHerVPT7fbqrp9ukerLUP16gmZLeC96MA4jYqhx1i3Ds_7MQyVBs7aFQVIS0-2q_G0AsDYgs11T8nZ_PD001EcDlOILc_5MtaC115D2mksxCcLmpAO0FbtS8cSXXjOHU8ck7XUqQOQ4gsI_M5mtQHBeFnmz8ikaRv3nFBtdCJ0yoy1knFhZam99RKwp82E9kVEPqzFqC4HzgwFuQaKXN0WeURmKOdNP2S77i-0VxcqOI-SmWZF7VPDZckywXVtjUgyq21SGsjXIvIetaTQJ0E-cH3YWgDDRXYrdQApBMBaKdKI7I56gi_ZcfNazyr4cqe2lheRt5tmvBPr0xrXXvd9co5cezCWcmQfozcbtzS_fvZ83piVwy9_8f9_f0PugcWr718W316S-3js_VBUuEsmy6tr9wrA0dK8Dlb_F9YjEm8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Next+Generation+Mucosal+Vaccine+Strategy+for+Respiratory+Pathogens&rft.jtitle=Vaccines+%28Basel%29&rft.au=Dotiwala%2C+Farokh&rft.au=Upadhyay%2C+Arun+K.&rft.date=2023-10-01&rft.pub=MDPI&rft.eissn=2076-393X&rft.volume=11&rft.issue=10&rft_id=info:doi/10.3390%2Fvaccines11101585&rft_id=info%3Apmid%2F37896988&rft.externalDBID=PMC10611113
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2076-393X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2076-393X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2076-393X&client=summon