CRELD2, endoplasmic reticulum stress, and human diseases

• Published in: Frontiers in endocrinology (Lausanne) Vol. 14; p. 1117414
• Main Authors: Tang, Qin, Liu, Qinhui, Li, Yanping, Mo, Li, He, Jinhan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.03.2023
• Subjects: Cell Adhesion Molecules - metabolism; CRELD2; Endocrinology; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum Stress; Epidermal Growth Factor - metabolism; Extracellular Matrix Proteins; human diseases; Humans; metabolism; unfolded protein response; unfolded protein response; metabolism; human diseases; CRELD2; endoplasmic reticulum stress

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple...