CRELD2, endoplasmic reticulum stress, and human diseases

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in endocrinology (Lausanne) Vol. 14; p. 1117414
Main Authors Tang, Qin, Liu, Qinhui, Li, Yanping, Mo, Li, He, Jinhan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.03.2023
Subjects
Cell Adhesion Molecules - metabolism
CRELD2
Endocrinology
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum Stress
Epidermal Growth Factor - metabolism
Extracellular Matrix Proteins
human diseases
Humans
metabolism
unfolded protein response
unfolded protein response
metabolism
human diseases
CRELD2
endoplasmic reticulum stress
Online AccessGet full text

Cover

Abstract CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. Recent studies suggest that CRELD2 is associated with cartilage/bone metabolism homeostasis and pathological conditions involving ER stress such as chronic liver diseases, cardiovascular diseases, kidney diseases, and cancer. Herein, we first summarize ER stress and then critically review recent advances in the knowledge of the characteristics and functions of CRELD2 in various human diseases. Furthermore, we highlight challenges and present future directions to elucidate the roles of CRELD2 in human health and disease.
AbstractList CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. Recent studies suggest that CRELD2 is associated with cartilage/bone metabolism homeostasis and pathological conditions involving ER stress such as chronic liver diseases, cardiovascular diseases, kidney diseases, and cancer. Herein, we first summarize ER stress and then critically review recent advances in the knowledge of the characteristics and functions of CRELD2 in various human diseases. Furthermore, we highlight challenges and present future directions to elucidate the roles of CRELD2 in human health and disease.
CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. Recent studies suggest that CRELD2 is associated with cartilage/bone metabolism homeostasis and pathological conditions involving ER stress such as chronic liver diseases, cardiovascular diseases, kidney diseases, and cancer. Herein, we first summarize ER stress and then critically review recent advances in the knowledge of the characteristics and functions of CRELD2 in various human diseases. Furthermore, we highlight challenges and present future directions to elucidate the roles of CRELD2 in human health and disease.CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. Recent studies suggest that CRELD2 is associated with cartilage/bone metabolism homeostasis and pathological conditions involving ER stress such as chronic liver diseases, cardiovascular diseases, kidney diseases, and cancer. Herein, we first summarize ER stress and then critically review recent advances in the knowledge of the characteristics and functions of CRELD2 in various human diseases. Furthermore, we highlight challenges and present future directions to elucidate the roles of CRELD2 in human health and disease.
Author Liu, Qinhui
He, Jinhan
Mo, Li
Tang, Qin
Li, Yanping
AuthorAffiliation 1 Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan , China
2 Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu , China
AuthorAffiliation_xml – name: 1 Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan , China
– name: 2 Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu , China
Author_xml – sequence: 1
  givenname: Qin
  surname: Tang
  fullname: Tang, Qin
– sequence: 2
  givenname: Qinhui
  surname: Liu
  fullname: Liu, Qinhui
– sequence: 3
  givenname: Yanping
  surname: Li
  fullname: Li, Yanping
– sequence: 4
  givenname: Li
  surname: Mo
  fullname: Mo, Li
– sequence: 5
  givenname: Jinhan
  surname: He
  fullname: He, Jinhan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36936176$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtvEzEUhS1UREvpH2CBZsmiCX4_VgiFApUiISFYW3f8aF3NjIM9g8S_x2lS1LLAG1v2Od-58nmJTqY8BYReE7xmTJt3MUw-rymmbE0IUZzwZ-iMSMlXlBl68uh8ii5qvcNtcUyM0S_QKZOGSaLkGdKbb1fbj_Sy2-N2A9Qxua6EObllWMauziXUetnB5LvbZYSp86kGqKG-Qs8jDDVcHPdz9OPT1ffNl9X26-frzYftygkm5hUI5wRmSksdKRBwFKTyWAnPmIsKawF9DJFyTVQE7ykhoRdt1j460K5n5-j6wPUZ7uyupBHKb5sh2fuLXG4slDbuECzVRvAQJZeC8QBa90ZxHD3uGeOG-MZ6f2Dtln4M3oVpLjA8gT59mdKtvcm_LMGYaMxkI7w9Ekr-uYQ62zFVF4YBppCXaqnSWmNBhWnSN4_D_qY8_H0T6IPAlVxrCdG6NMOc8j47DS3U7pu2903bfdP22HSz0n-sD_T_mP4ABiSr-A
CitedBy_id crossref_primary_10_1097_IMNA_D_24_00050
crossref_primary_10_3390_cells14050372
crossref_primary_10_1007_s10565_024_09949_3
crossref_primary_10_1007_s12550_025_00586_1
crossref_primary_10_1002_arch_22082
crossref_primary_10_12677_acm_2024_1461756
crossref_primary_10_3389_fendo_2023_1286979
crossref_primary_10_1002_cm_21894
Cites_doi 10.1371/journal.pone.0146923
10.1371/journal.pone.0024600
10.1016/j.yjmcc.2021.03.008
10.1074/jbc.RA118.002121
10.1007/s10456-007-9075-z
10.1038/s41598-018-30362-4
10.1074/jbc.M302221200
10.1007/s00467-018-4031-2
10.1073/pnas.0606480103
10.2337/db20-0840
10.1016/S0378-1119(02)00696-0
10.1172/JCI0216886
10.1016/j.cell.2009.07.017
10.1007/s11010-015-2639-0
10.1091/mbc.10.11.3787
10.1016/j.bbrc.2009.07.047
10.1007/s10565-014-9274-5
10.1016/j.cellsig.2020.109880
10.1093/toxsci/kfs203
10.1096/fj.202002713RR
10.1016/S1097-2765(00)00133-7
10.15252/embj.201490332
10.1042/CS20190399
10.1242/jcs.045625
10.1038/ni.3709
10.2337/db16-0052
10.1038/352337a0
10.1002/ajmg.a.35457
10.3389/fonc.2015.00007
10.1038/s41556-020-0523-y
10.1038/sj.embor.7400311
10.1016/j.cmet.2020.11.009
10.1016/j.trecan.2022.06.006
10.1007/s11010-011-1155-0
10.1172/jci.insight.92896
10.1007/s12192-010-0193-y
10.1002/ajmg.a.31494
10.1038/s41573-021-00320-3
10.1016/j.cub.2006.09.060
10.1038/16729
10.3390/ijms20225614
10.1242/jcs.250100
10.1016/j.acthis.2021.151679
10.1083/jcb.200903014
10.3389/fgene.2013.00224
10.1086/374319
10.1002/ajmg.a.35626
10.1016/j.ejphar.2022.174903
10.1038/nrneph.2017.129
10.1083/jcb.200406136
10.1161/CIRCRESAHA.108.180679
10.1002/ajmg.a.31018
10.1038/emboj.2012.134
10.3389/fnmol.2017.00222
10.1111/j.1742-4658.2007.06058.x
10.1111/j.1399-0004.2005.00435.x
10.1161/01.CIR.0000155243.70456.F4
10.1111/cpr.13011
10.1002/ptr.7539
10.1016/j.cell.2018.08.020
10.1074/jbc.273.50.33741
10.1111/j.1471-4159.2005.03473.x
10.1016/j.febslet.2011.06.029
10.1016/j.prp.2019.152510
10.3390/ijms151223501
10.1016/0092-8674(87)90086-9
10.1016/j.tem.2022.01.001
10.1161/CIRCGENETICS.111.960872
10.3390/ijms18030665
10.1016/j.devcel.2014.02.012
10.1002/hep.31428
10.1101/gad.12.12.1812
10.1016/S0021-9258(19)61473-0
10.1126/science.1226191
10.1126/science.287.5453.664
10.1016/S0092-8674(01)00611-0
10.1016/S0092-8674(00)80608-X
10.1302/2046-3758.84.BJR-2018-0291.R1
10.1038/s41569-021-00511-w
10.1016/0003-9861(92)90554-A
10.1111/cas.13526
10.1002/hep.32562
10.1126/science.aaf3646
10.1016/j.gene.2006.06.016
10.1016/j.molcel.2022.03.025
10.1016/j.molcel.2017.06.017
10.1083/jcb.152.1.213
10.1016/j.tips.2021.11.011
10.1186/1476-4598-6-39
10.1038/415092a
10.1038/s41574-021-00510-4
10.1038/s41598-022-17347-0
10.1016/j.cmet.2020.11.010
10.1093/protein/gzn080
10.1016/j.gene.2016.03.034
10.1074/jbc.M112.356345
10.1016/j.bbadis.2018.10.029
10.1128/MCB.26.8.3071-3084.2006
10.1016/j.yjmcc.2010.10.008
10.1038/s41590-020-00811-2
10.1021/acs.jproteome.5b01115
10.1534/genetics.116.188045
10.1073/pnas.0400541101
10.1016/S2468-1253(20)30294-6
10.1016/j.phrs.2020.105218
10.1038/nature17041
10.1101/cshperspect.a033894
10.1073/pnas.0509487102
10.1247/csf.07001
10.1016/j.jhep.2020.10.030
10.1016/j.jhep.2020.03.039
10.12703/P6-88
10.1002/jbmr.4010
10.3390/ijms22042161
10.1016/j.trim.2021.101474
10.1016/j.yexcr.2008.05.001
10.1038/s41401-021-00629-0
10.1248/bpb.b14-00825
10.1038/s41580-020-0250-z
10.1016/j.febslet.2007.01.091
10.1007/s12519-010-0235-7
10.1093/hmg/ddt383
10.1074/jbc.M112.400648
10.1002/jcla.22660
10.1126/science.1129631
10.1038/s41467-019-08450-4
10.1371/journal.pone.0073086
ContentType Journal Article
Copyright Copyright © 2023 Tang, Liu, Li, Mo and He.
Copyright © 2023 Tang, Liu, Li, Mo and He 2023 Tang, Liu, Li, Mo and He
Copyright_xml – notice: Copyright © 2023 Tang, Liu, Li, Mo and He.
– notice: Copyright © 2023 Tang, Liu, Li, Mo and He 2023 Tang, Liu, Li, Mo and He
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOA
DOI 10.3389/fendo.2023.1117414
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
CrossRef
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1664-2392
ExternalDocumentID oai_doaj_org_article_28954ef646534ea88b9740fd0b33491d
PMC10018036
36936176
10_3389_fendo_2023_1117414
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: ;
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EMOBN
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
OK1
PGMZT
RPM
CGR
CUY
CVF
ECM
EIF
IAO
IEA
IHR
IHW
IPNFZ
NPM
RIG
7X8
5PM
ID FETCH-LOGICAL-c535t-a5cc5037868f2a1ac2a67d075d33cf7085abfef24817fadd211eb5000bfca8cb3
IEDL.DBID M48
ISSN 1664-2392
IngestDate Wed Aug 27 01:05:12 EDT 2025
Thu Aug 21 18:37:30 EDT 2025
Thu Jul 10 17:22:58 EDT 2025
Thu Jan 02 22:52:56 EST 2025
Thu Apr 24 23:04:25 EDT 2025
Tue Jul 01 01:41:38 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords unfolded protein response
metabolism
human diseases
CRELD2
endoplasmic reticulum stress
Language English
License Copyright © 2023 Tang, Liu, Li, Mo and He.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c535t-a5cc5037868f2a1ac2a67d075d33cf7085abfef24817fadd211eb5000bfca8cb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Reviewed by: Lorenzo Bonaguro, University of Bonn, Germany; Nora Balzer, Helmholtz Association of German Research Centers (HZ), Germany
Edited by: Guojun Shi, Sun Yat-sen University, China
This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fendo.2023.1117414
PMID 36936176
PQID 2788805259
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_28954ef646534ea88b9740fd0b33491d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10018036
proquest_miscellaneous_2788805259
pubmed_primary_36936176
crossref_citationtrail_10_3389_fendo_2023_1117414
crossref_primary_10_3389_fendo_2023_1117414
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-03-02
PublicationDateYYYYMMDD 2023-03-02
PublicationDate_xml – month: 03
  year: 2023
  text: 2023-03-02
  day: 02
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in endocrinology (Lausanne)
PublicationTitleAlternate Front Endocrinol (Lausanne)
PublicationYear 2023
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Yan (B92) 2019; 10
Hu (B50) 2006; 26
Munro (B62) 1987; 48
Haze (B55) 1999; 10
Aridor (B75) 2001; 152
Sato (B76) 2007; 581
Oh-Hashi (B65) 2012; 363
Hughes (B122) 2017; 18
Mass (B29) 2014; 28
Horna-Terrón (B119) 2014; 15
Bard (B78) 2003; 278
Jariwala (B105) 2007; 6
Li (B24) 2012; 5
Ajoolabady (B3) 2023; 77
Robinson (B18) 2003; 72
Tirasophon (B39) 1998; 12
Eslam (B113) 2020; 73
Nohara (B117) 2012; 129
Guo (B123) 2021; 54
Nundlall (B98) 2010; 15
Duxfield (B103) 2022; 12
Yong (B5) 2021; 17
Zatyka (B20) 2005; 67
Yoshida (B34) 1998; 273
Apostolou (B88) 2008; 314
Hatahet (B70) 2007; 274
Oh-hashi (B74) 2014; 30
Liu (B107) 2019; 215
Wiersma (B82) 2015; 5
Kaufman (B36) 2002; 110
Cameron (B99) 2011; 6
Dietz (B120) 1991; 352
Li (B126) 2021; 22
Upton (B48) 2012; 338
Calfon (B43) 2002; 415
Henderson (B90) 2013; 288
Li (B30) 2016; 203
Rellmann (B61) 2021; 78
Wang (B49) 2017; 66
Xia (B111) 2020; 161
Mizobuchi (B87) 2007; 32
Luini (B81) 2014; 6
Glembotski (B64) 2012; 287
Tirosh (B9) 2021; 33
Harding (B35) 1999; 397
Bommiasamy (B58) 2009; 122
Xu (B11) 2021; 73
Zhang (B101) 2013; 8
Urano (B51) 2000; 287
Zhou (B41) 2006; 103
Boyle (B108) 2020; 22
Wang (B54) 2000; 275
Neves (B91) 2016; 353
Wiseman (B33) 2022; 82
Han (B95) 2013; 4
Navas-Madroñal (B96) 2019; 133
Hollien (B46) 2006; 313
Stauber (B79) 2006; 16
Sisk (B127) 2021; 69
Sharpton (B115) 2021; 33
Yamada (B106) 2018; 109
Maslen (B28) 2006; 382
Marciniak (B6) 2022; 21
Preissler (B38) 2019; 11
Ortiz (B27) 2005; 95
Salvagno (B1) 2022; 8
Ren (B12) 2021; 18
Oh-Hashi (B73) 2018; 8
Cybulsky (B13) 2017; 13
Park (B125) 2019; 34
Beckert (B32) 2021; 156
Lee (B60) 2022; 922
Ye (B56) 2000; 6
Kern (B118) 2016; 586
Albig (B104) 2007; 10
Kokubun (B84) 2019; 20
Siegert (B97) 2019; 1865
Chen (B109) 2019; 8
Oh-hashi (B14) 2009; 387
Wilson (B100) 2016; 15
Dennis (B102) 2020; 35
Wang (B2) 2016; 529
Hetz (B53) 2018; 69
Oh-hashi (B86) 2015; 38
Tang (B66) 2022; 33
Yarmohammadi (B124) 2022; 36
Jurkin (B44) 2014; 33
Takemoto (B63) 1992; 296
Li (B26) 2019; 33
Giannotta (B80) 2012; 31
Han (B45) 2009; 138
Sriburi (B59) 2004; 167
Jin (B83) 2017; 10
Rupp (B17) 2002; 293
Walter (B57) 2018; 293
Ghosh (B23) 2012
Liu (B71) 2016; 413
Sarkozy (B19) 2005; 139
Shih (B4) 2021; 70
Shan (B8) 2017; 18
Hetz (B37) 2020; 21
Parkash (B89) 2009; 22
Shiha (B114) 2021; 6
Kim (B10) 2018; 175
Norisada (B93) 2016; 11
Kern (B94) 2021; 35
Newstead (B68) 2020; 133
Glembotski (B85) 2011; 51
Hollien (B47) 2009; 186
Oh-hashi (B15) 2011; 585
Zhian (B25) 2012
Hartley (B16) 2013; 22
Credle (B40) 2005; 102
Tadimalla (B67) 2008; 103
Yoshida (B42) 2001; 107
Kim (B72) 2017; 2
Ellgaard (B69) 2005; 6
Milewicz (B121) 2005; 111
Lasić (B110) 2021; 123
Guo (B22) 2010; 6
Martínez-Menárguez (B77) 1999; 98
Ajoolabady (B7) 2022; 43
Maslen (B21) 2006; 140
Wang (B112) 2022; 43
Kucukoglu (B116) 2021; 74
Bonaguro (B31) 2020; 21
Vattem (B52) 2004; 101
References_xml – volume: 11
  year: 2016
  ident: B93
  article-title: A comparative analysis of the molecular features of MANF and CDNF
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0146923
– volume: 6
  year: 2011
  ident: B99
  article-title: Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0024600
– volume: 156
  start-page: 45
  year: 2021
  ident: B32
  article-title: Creld1 regulates myocardial development and function
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2021.03.008
– volume: 293
  year: 2018
  ident: B57
  article-title: ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch"
  publication-title: J Biol Chem
  doi: 10.1074/jbc.RA118.002121
– volume: 10
  start-page: 197
  year: 2007
  ident: B104
  article-title: Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis
  publication-title: Angiogenesis
  doi: 10.1007/s10456-007-9075-z
– volume: 8
  start-page: 12236
  year: 2018
  ident: B73
  article-title: Expression analysis and functional characterization of the mouse cysteine-rich with EGF-like domains 2
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-30362-4
– volume: 278
  year: 2003
  ident: B78
  article-title: Src regulates golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M302221200
– volume: 34
  year: 2019
  ident: B125
  article-title: Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology
  publication-title: Pediatr Nephrol
  doi: 10.1007/s00467-018-4031-2
– volume: 103
  year: 2006
  ident: B41
  article-title: The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
  publication-title: Proc Natl Acad Sci U.S.A.
  doi: 10.1073/pnas.0606480103
– volume: 70
  year: 2021
  ident: B4
  article-title: Dapagliflozin suppresses ER stress and improves subclinical myocardial function in diabetes: From bedside to bench
  publication-title: Diabetes
  doi: 10.2337/db20-0840
– volume: 293
  start-page: 47
  year: 2002
  ident: B17
  article-title: Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins
  publication-title: Gene
  doi: 10.1016/S0378-1119(02)00696-0
– volume: 110
  year: 2002
  ident: B36
  article-title: Orchestrating the unfolded protein response in health and disease
  publication-title: J Clin Invest
  doi: 10.1172/JCI0216886
– volume: 138
  year: 2009
  ident: B45
  article-title: IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
  publication-title: Cell
  doi: 10.1016/j.cell.2009.07.017
– volume: 413
  start-page: 57
  year: 2016
  ident: B71
  article-title: Genome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-015-2639-0
– volume: 10
  year: 1999
  ident: B55
  article-title: Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.10.11.3787
– volume: 387
  year: 2009
  ident: B14
  article-title: CRELD2 is a novel endoplasmic reticulum stress-inducible gene
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.07.047
– volume: 30
  year: 2014
  ident: B74
  article-title: Characterization of V-ATPase inhibitor-induced secretion of cysteine-rich with EGF-like domains 2
  publication-title: Cell Biol Toxicol
  doi: 10.1007/s10565-014-9274-5
– volume: 78
  start-page: 109880
  year: 2021
  ident: B61
  article-title: Review: ER stress-induced cell death in osteoarthritic cartilage
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2020.109880
– volume: 129
  start-page: 293
  year: 2012
  ident: B117
  article-title: Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic
  publication-title: Toxicol Sci
  doi: 10.1093/toxsci/kfs203
– volume: 35
  year: 2021
  ident: B94
  article-title: Creld2 function during unfolded protein response is essential for liver metabolism homeostasis
  publication-title: FASEB J
  doi: 10.1096/fj.202002713RR
– volume: 6
  year: 2000
  ident: B56
  article-title: ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(00)00133-7
– volume: 33
  year: 2014
  ident: B44
  article-title: The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
  publication-title: EMBO J
  doi: 10.15252/embj.201490332
– volume: 133
  year: 2019
  ident: B96
  article-title: Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20190399
– volume: 122
  year: 2009
  ident: B58
  article-title: ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum
  publication-title: J Cell Sci
  doi: 10.1242/jcs.045625
– volume: 18
  year: 2017
  ident: B8
  article-title: The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
  publication-title: Nat Immunol
  doi: 10.1038/ni.3709
– volume: 66
  year: 2017
  ident: B49
  article-title: Inositol-requiring enzyme 1 facilitates diabetic wound healing through modulating MicroRNAs
  publication-title: Diabetes
  doi: 10.2337/db16-0052
– volume: 352
  year: 1991
  ident: B120
  article-title: Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene
  publication-title: Nature
  doi: 10.1038/352337a0
– year: 2012
  ident: B25
  article-title: Specific association of missense mutations in CRELD1 with cardiac atrioventricular septal defects in heterotaxy syndrome
  publication-title: Am J Med Genet A
  doi: 10.1002/ajmg.a.35457
– volume: 5
  year: 2015
  ident: B82
  article-title: Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity
  publication-title: Front Oncol
  doi: 10.3389/fonc.2015.00007
– volume: 22
  year: 2020
  ident: B108
  article-title: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism
  publication-title: Nat Cell Biol
  doi: 10.1038/s41556-020-0523-y
– volume: 6
  start-page: 28
  year: 2005
  ident: B69
  article-title: The human protein disulphide isomerase family: substrate interactions and functional properties
  publication-title: EMBO Rep
  doi: 10.1038/sj.embor.7400311
– volume: 33
  start-page: 319
  year: 2021
  ident: B9
  article-title: Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2020.11.009
– volume: 8
  year: 2022
  ident: B1
  article-title: Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity
  publication-title: Trends Cancer
  doi: 10.1016/j.trecan.2022.06.006
– volume: 363
  start-page: 35
  year: 2012
  ident: B65
  article-title: Intracellular trafficking and secretion of mouse mesencephalic astrocyte-derived neurotrophic factor
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-011-1155-0
– volume: 2
  start-page: e92896
  year: 2017
  ident: B72
  article-title: Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.92896
– volume: 15
  year: 2010
  ident: B98
  article-title: An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia
  publication-title: Cell Stress Chaperones
  doi: 10.1007/s12192-010-0193-y
– volume: 140
  year: 2006
  ident: B21
  article-title: CRELD1 mutations contribute to the occurrence of cardiac atrioventricular septal defects in down syndrome
  publication-title: Am J Med Genet A
  doi: 10.1002/ajmg.a.31494
– volume: 21
  year: 2022
  ident: B6
  article-title: Pharmacological targeting of endoplasmic reticulum stress in disease
  publication-title: Nat Rev Drug Discovery
  doi: 10.1038/s41573-021-00320-3
– volume: 16
  year: 2006
  ident: B79
  article-title: A role for kinesin-2 in COPI-dependent recycling between the ER and the golgi complex
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2006.09.060
– volume: 397
  year: 1999
  ident: B35
  article-title: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
  publication-title: Nature
  doi: 10.1038/16729
– volume: 20
  start-page: 5614
  year: 2019
  ident: B84
  article-title: Pathogenic effects of impaired retrieval between the endoplasmic reticulum and golgi complex
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20225614
– volume: 133
  start-page: jcs250100
  year: 2020
  ident: B68
  article-title: Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins - SWEET talking the COPs
  publication-title: J Cell Sci
  doi: 10.1242/jcs.250100
– volume: 123
  start-page: 151679
  year: 2021
  ident: B110
  article-title: GREB1L, CRELD2 and ITGA10 expression in the human developmental and postnatal kidneys: An immunohistochemical study
  publication-title: Acta Histochem
  doi: 10.1016/j.acthis.2021.151679
– volume: 186
  year: 2009
  ident: B47
  article-title: Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200903014
– volume: 4
  year: 2013
  ident: B95
  article-title: Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors
  publication-title: Front Genet
  doi: 10.3389/fgene.2013.00224
– volume: 72
  year: 2003
  ident: B18
  article-title: Missense mutations in CRELD1 are associated with cardiac atrioventricular septal defects
  publication-title: Am J Hum Genet
  doi: 10.1086/374319
– year: 2012
  ident: B23
  article-title: Polymorphic haplotypes of CRELD1 differentially predispose down syndrome and euploids individuals to atrioventricular septal defect
  publication-title: Am J Med Genet A
  doi: 10.1002/ajmg.a.35626
– volume: 922
  start-page: 174903
  year: 2022
  ident: B60
  article-title: Naturally-derived endoplasmic reticulum stress inhibitors for osteoarthritis
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2022.174903
– volume: 13
  year: 2017
  ident: B13
  article-title: Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases
  publication-title: Nat Rev Nephrol
  doi: 10.1038/nrneph.2017.129
– volume: 167
  start-page: 35
  year: 2004
  ident: B59
  article-title: XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200406136
– volume: 103
  year: 2008
  ident: B67
  article-title: Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.108.180679
– volume: 139
  year: 2005
  ident: B19
  article-title: CRELD1 and GATA4 gene analysis in patients with nonsyndromic atrioventricular canal defects
  publication-title: Am J Med Genet A
  doi: 10.1002/ajmg.a.31018
– volume: 31
  year: 2012
  ident: B80
  article-title: The KDEL receptor couples to Gαq/11 to activate src kinases and regulate transport through the golgi
  publication-title: EMBO J
  doi: 10.1038/emboj.2012.134
– volume: 10
  year: 2017
  ident: B83
  article-title: The role of BiP retrieval by the KDEL receptor in the early secretory pathway and its effect on protein quality control and neurodegeneration
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2017.00222
– volume: 274
  year: 2007
  ident: B70
  article-title: Substrate recognition by the protein disulfide isomerases
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2007.06058.x
– volume: 67
  year: 2005
  ident: B20
  article-title: Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2)
  publication-title: Clin Genet
  doi: 10.1111/j.1399-0004.2005.00435.x
– volume: 111
  year: 2005
  ident: B121
  article-title: Treatment of aortic disease in patients with marfan syndrome
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000155243.70456.F4
– volume: 54
  year: 2021
  ident: B123
  article-title: PERK signaling pathway in bone metabolism: Friend or foe
  publication-title: Cell Prolif
  doi: 10.1111/cpr.13011
– volume: 36
  year: 2022
  ident: B124
  article-title: The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
  publication-title: Phytother Res
  doi: 10.1002/ptr.7539
– volume: 175
  start-page: 133
  year: 2018
  ident: B10
  article-title: ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P
  publication-title: Cell
  doi: 10.1016/j.cell.2018.08.020
– volume: 273
  year: 1998
  ident: B34
  article-title: Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. involvement of basic leucine zipper transcription factors
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.50.33741
– volume: 95
  year: 2005
  ident: B27
  article-title: The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03473.x
– volume: 585
  year: 2011
  ident: B15
  article-title: Biosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2011.06.029
– volume: 215
  start-page: 152510
  year: 2019
  ident: B107
  article-title: Key genes associated with diabetes mellitus and hepatocellular carcinoma
  publication-title: Pathol Res Pract
  doi: 10.1016/j.prp.2019.152510
– volume: 15
  year: 2014
  ident: B119
  article-title: TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms151223501
– volume: 48
  start-page: 899
  year: 1987
  ident: B62
  article-title: A c-terminal signal prevents secretion of luminal ER proteins
  publication-title: Cell
  doi: 10.1016/0092-8674(87)90086-9
– volume: 33
  year: 2022
  ident: B66
  article-title: MANF: an emerging therapeutic target for metabolic diseases
  publication-title: Trends Endocrinol Metab
  doi: 10.1016/j.tem.2022.01.001
– volume: 5
  year: 2012
  ident: B24
  article-title: Genetic modifiers predisposing to congenital heart disease in the sensitized down syndrome population
  publication-title: Circ Cardiovasc Genet
  doi: 10.1161/CIRCGENETICS.111.960872
– volume: 18
  start-page: 665
  year: 2017
  ident: B122
  article-title: Endoplasmic reticulum stress and unfolded protein response in cartilage pathophysiology; contributing factors to apoptosis and osteoarthritis
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18030665
– volume: 28
  year: 2014
  ident: B29
  article-title: Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2014.02.012
– volume: 73
  year: 2021
  ident: B11
  article-title: An endoplasmic reticulum stress-MicroRNA-26a feedback circuit in NAFLD
  publication-title: Hepatology
  doi: 10.1002/hep.31428
– volume: 12
  year: 1998
  ident: B39
  article-title: A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
  publication-title: Genes Dev
  doi: 10.1101/gad.12.12.1812
– volume: 275
  year: 2000
  ident: B54
  article-title: Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)61473-0
– volume: 338
  year: 2012
  ident: B48
  article-title: IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic caspase-2
  publication-title: Science
  doi: 10.1126/science.1226191
– volume: 287
  year: 2000
  ident: B51
  article-title: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
  publication-title: Science
  doi: 10.1126/science.287.5453.664
– volume: 107
  year: 2001
  ident: B42
  article-title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
  publication-title: Cell
  doi: 10.1016/S0092-8674(01)00611-0
– volume: 98
  start-page: 81
  year: 1999
  ident: B77
  article-title: Vesicular tubular clusters between the ER and golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80608-X
– volume: 8
  year: 2019
  ident: B109
  article-title: Synovial fluid interleukin-16, interleukin-18, and CRELD2 as novel biomarkers of prosthetic joint infections
  publication-title: Bone Joint Res
  doi: 10.1302/2046-3758.84.BJR-2018-0291.R1
– volume: 18
  start-page: 499
  year: 2021
  ident: B12
  article-title: Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
  publication-title: Nat Rev Cardiol
  doi: 10.1038/s41569-021-00511-w
– volume: 296
  year: 1992
  ident: B63
  article-title: Heavy chain binding protein (BiP/GRP78) and endoplasmin are exported from the endoplasmic reticulum in rat exocrine pancreatic cells, similar to protein disulfide-isomerase
  publication-title: Arch Biochem Biophys
  doi: 10.1016/0003-9861(92)90554-A
– volume: 109
  year: 2018
  ident: B106
  article-title: Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma
  publication-title: Cancer Sci
  doi: 10.1111/cas.13526
– volume: 77
  year: 2023
  ident: B3
  article-title: Endoplasmic reticulum stress in liver diseases
  publication-title: Hepatology
  doi: 10.1002/hep.32562
– volume: 353
  start-page: aaf3646
  year: 2016
  ident: B91
  article-title: Immune modulation by MANF promotes tissue repair and regenerative success in the retina
  publication-title: Science
  doi: 10.1126/science.aaf3646
– volume: 382
  year: 2006
  ident: B28
  article-title: CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region
  publication-title: Gene
  doi: 10.1016/j.gene.2006.06.016
– volume: 82
  year: 2022
  ident: B33
  article-title: Reshaping endoplasmic reticulum quality control through the unfolded protein response
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2022.03.025
– volume: 69
  year: 2018
  ident: B53
  article-title: The unfolded protein response and cell fate control
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2017.06.017
– volume: 152
  year: 2001
  ident: B75
  article-title: The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly
  publication-title: J Cell Biol
  doi: 10.1083/jcb.152.1.213
– volume: 43
  start-page: 97
  year: 2022
  ident: B7
  article-title: ER stress in obesity pathogenesis and management
  publication-title: Trends Pharmacol Sci
  doi: 10.1016/j.tips.2021.11.011
– volume: 6
  start-page: 39
  year: 2007
  ident: B105
  article-title: Identification of novel androgen receptor target genes in prostate cancer
  publication-title: Mol Cancer
  doi: 10.1186/1476-4598-6-39
– volume: 415
  year: 2002
  ident: B43
  article-title: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
  publication-title: Nature
  doi: 10.1038/415092a
– volume: 17
  year: 2021
  ident: B5
  article-title: Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-021-00510-4
– volume: 12
  start-page: 13884
  year: 2022
  ident: B103
  article-title: CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation
  publication-title: Sci Rep
  doi: 10.1038/s41598-022-17347-0
– volume: 33
  start-page: 21
  year: 2021
  ident: B115
  article-title: Current concepts, opportunities, and challenges of gut microbiome-based personalized medicine in nonalcoholic fatty liver disease
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2020.11.010
– volume: 22
  year: 2009
  ident: B89
  article-title: The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional
  publication-title: Protein Eng Des Sel
  doi: 10.1093/protein/gzn080
– volume: 586
  start-page: 12
  year: 2016
  ident: B118
  article-title: Transcriptome differences in the rumen of beef steers with variation in feed intake and gain
  publication-title: Gene
  doi: 10.1016/j.gene.2016.03.034
– volume: 287
  year: 2012
  ident: B64
  article-title: Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.356345
– volume: 1865
  year: 2019
  ident: B97
  article-title: A FBN1 3'UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in marfan syndrome
  publication-title: Biochim Biophys Acta Mol Basis Dis
  doi: 10.1016/j.bbadis.2018.10.029
– volume: 26
  year: 2006
  ident: B50
  article-title: Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.8.3071-3084.2006
– volume: 51
  year: 2011
  ident: B85
  article-title: Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2010.10.008
– volume: 21
  year: 2020
  ident: B31
  article-title: CRELD1 modulates homeostasis of the immune system in mice and humans
  publication-title: Nat Immunol
  doi: 10.1038/s41590-020-00811-2
– volume: 15
  year: 2016
  ident: B100
  article-title: Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation
  publication-title: J Proteome Res
  doi: 10.1021/acs.jproteome.5b01115
– volume: 203
  year: 2016
  ident: B30
  article-title: Penetrance of congenital heart disease in a mouse model of down syndrome depends on a trisomic potentiator of a disomic modifier
  publication-title: Genetics
  doi: 10.1534/genetics.116.188045
– volume: 101
  year: 2004
  ident: B52
  article-title: Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
  publication-title: Proc Natl Acad Sci U.S.A.
  doi: 10.1073/pnas.0400541101
– volume: 6
  year: 2021
  ident: B114
  article-title: Redefining fatty liver disease: An international patient perspective
  publication-title: Lancet Gastroenterol Hepatol
  doi: 10.1016/S2468-1253(20)30294-6
– volume: 161
  start-page: 105218
  year: 2020
  ident: B111
  article-title: Endoplasmic reticulum stress and protein degradation in chronic liver disease
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2020.105218
– volume: 529
  year: 2016
  ident: B2
  article-title: Protein misfolding in the endoplasmic reticulum as a conduit to human disease
  publication-title: Nature
  doi: 10.1038/nature17041
– volume: 11
  start-page: a033894
  year: 2019
  ident: B38
  article-title: Early events in the endoplasmic reticulum unfolded protein response
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a033894
– volume: 102
  year: 2005
  ident: B40
  article-title: On the mechanism of sensing unfolded protein in the endoplasmic reticulum
  publication-title: Proc Natl Acad Sci U.S.A.
  doi: 10.1073/pnas.0509487102
– volume: 32
  start-page: 41
  year: 2007
  ident: B87
  article-title: ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element
  publication-title: Cell Struct Funct
  doi: 10.1247/csf.07001
– volume: 74
  year: 2021
  ident: B116
  article-title: Hepatokines and adipokines in NASH-related hepatocellular carcinoma
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2020.10.030
– volume: 73
  year: 2020
  ident: B113
  article-title: A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2020.03.039
– volume: 6
  start-page: 88
  year: 2014
  ident: B81
  article-title: Control systems and coordination protocols of the secretory pathway
  publication-title: F1000Prime Rep
  doi: 10.12703/P6-88
– volume: 35
  year: 2020
  ident: B102
  article-title: CRELD2 is a novel LRP1 chaperone that regulates noncanonical WNT signaling in skeletal development
  publication-title: J Bone Miner Res
  doi: 10.1002/jbmr.4010
– volume: 22
  start-page: 2161
  year: 2021
  ident: B126
  article-title: Endoplasmic reticulum-associated biomarkers for molecular phenotyping of rare kidney disease
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms22042161
– volume: 69
  start-page: 101474
  year: 2021
  ident: B127
  article-title: A descriptive analysis of non-human leukocyte antigens present in renal transplant donor-recipient pairs
  publication-title: Transpl Immunol
  doi: 10.1016/j.trim.2021.101474
– volume: 314
  year: 2008
  ident: B88
  article-title: Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2008.05.001
– volume: 43
  year: 2022
  ident: B112
  article-title: Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/s41401-021-00629-0
– volume: 38
  year: 2015
  ident: B86
  article-title: Characterization of the role of MANF in regulating the secretion of CRELD2
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b14-00825
– volume: 21
  year: 2020
  ident: B37
  article-title: Mechanisms, regulation and functions of the unfolded protein response
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-020-0250-z
– volume: 581
  year: 2007
  ident: B76
  article-title: Mechanisms of COPII vesicle formation and protein sorting
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2007.01.091
– volume: 6
  year: 2010
  ident: B22
  article-title: Novel CRELD1 gene mutations in patients with atrioventricular septal defect
  publication-title: World J Pediatr
  doi: 10.1007/s12519-010-0235-7
– volume: 22
  year: 2013
  ident: B16
  article-title: Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: Implications for genetic skeletal diseases
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddt383
– volume: 288
  year: 2013
  ident: B90
  article-title: Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.400648
– volume: 33
  year: 2019
  ident: B26
  article-title: Copy number variations in the GATA4, NKX2-5, TBX5, BMP4 CRELD1, and 22q11.2 gene regions in Chinese children with sporadic congenital heart disease
  publication-title: J Clin Lab Anal
  doi: 10.1002/jcla.22660
– volume: 313
  year: 2006
  ident: B46
  article-title: Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
  publication-title: Science
  doi: 10.1126/science.1129631
– volume: 10
  start-page: 541
  year: 2019
  ident: B92
  article-title: MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-08450-4
– volume: 8
  year: 2013
  ident: B101
  article-title: Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0073086
SSID ssj0000401998
Score 2.3802938
SecondaryResourceType review_article
Snippet CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1117414
SubjectTerms Cell Adhesion Molecules - metabolism
CRELD2
Endocrinology
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum Stress
Epidermal Growth Factor - metabolism
Extracellular Matrix Proteins
human diseases
Humans
metabolism
unfolded protein response
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA6yB_Eivq0vKnjTst0k7SZHXRUR9SAKewt54oJ2F13_vzNpd9mK6MVrmzZhMp35vmYehJxQU0oZjMg4oOWMc-czDUwoQy5SOl1obmKU70N588xvh8VwodUXxoTV5YFrwXWBEBTchxLrgHGvhTCAgPPgcsMYlz2H1hd83gKZijYYaAMQiTpLBuaW3eArh8l-lKGVAD_KW54oFuz_CWV-D5Zc8D7Xa2S1gY3peb3cdbLkqw2yfN8cjG8SMXi8urukZynOPwFE_DayaUxQxL97aZ0RcpbqyqWxK1_aHMx8bJHn66unwU3WNEXIbMGKaaYLa4uc9UUpAtU9baku-w4cv2PMhj4gKG2CD5SLXj-A8QKC5w12PTDBamEN2yadalz5XZLywoJv8twByuBBSkOtoNJpnrOAr09IbyYgZZuK4di44lUBc0ChqihUhUJVjVATcjp_ZlLXy_h19AXKfT4Sa13HC6ABqtEA9ZcGJOR4tmsKvg088NCVH39-KIr8Hhv1yYTs1Ls4n4qVkgF6KxMiWvvbWkv7TjV6ifW3sWyVAM-_9x-r3ycrKJEY1kYPSGf6_ukPAedMzVFU6S8fsPhq
  priority: 102
  providerName: Directory of Open Access Journals
Title CRELD2, endoplasmic reticulum stress, and human diseases
URI https://www.ncbi.nlm.nih.gov/pubmed/36936176
https://www.proquest.com/docview/2788805259
https://pubmed.ncbi.nlm.nih.gov/PMC10018036
https://doaj.org/article/28954ef646534ea88b9740fd0b33491d
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwEB4hKlVcqr6gaSlKJW6QsrGdxDmgqqVQhKAHxEp7s_wEJJqlu4tU_j0zjnfVrWhPveSQ2Ik1E3u-z4_5ALaZqds2GFkIRMuFEM4XGplQQVykdrrSwsRdvt_r46E4GVWjFZjLHSUDTh-ldqQnNZzcfPz18_4Tdvh9YpwYb_eC7xyd42OcBoAm6lo_wcjUkKLBWYL7cWRGMoH0oj8785eqS_EppvF_DHv-uYXyt5h09ByeJTCZf-69_wJWfPcSnp6l5fJXIA_OD0-_st2cvn-LOPnHtc3jsUWa88v7cyK7ue5cHrX68rRcM30Nw6PDi4PjIkklFLbi1azQlbXVgDeyloHpUlum68YhHHCc29AgrtIm-MCELJuAQxrSPm9IC8EEq6U1fB1Wu3Hn30AuKosRywuH2EOEtjXMStY6LQY80OszKOcGUjblESc5ixuFfIKMqqJRFRlVJaNmsLOoc9tn0fhn6S9k90VJyoAdb4wnlyp1KIVEsRI-1JQfTngtpUFmNAhuYDgXbeky-DD3msIeQ8sguvPju6lixPpJvq_NYKP34uJTvG45Yro6A7nk36W2LD_prq9iVm5KZiURD7z9H61_B2tkkbjZjW3C6mxy598j-pmZrThrgNdvo3Ir_t4PydsDUQ
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CRELD2%2C+endoplasmic+reticulum+stress%2C+and+human+diseases&rft.jtitle=Frontiers+in+endocrinology+%28Lausanne%29&rft.au=Qin+Tang&rft.au=Qinhui+Liu&rft.au=Yanping+Li&rft.au=Li+Mo&rft.date=2023-03-02&rft.pub=Frontiers+Media+S.A&rft.eissn=1664-2392&rft.volume=14&rft_id=info:doi/10.3389%2Ffendo.2023.1117414&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_28954ef646534ea88b9740fd0b33491d
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2392&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2392&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2392&client=summon