The Influence of Sildenafil–Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice

• Published in: Medicina (Kaunas, Lithuania) Vol. 59; no. 8; p. 1375
• Main Authors: Pușcașu, Ciprian, Ungurianu, Anca, Șeremet, Oana Cristina, Andrei, Corina, Mihai, Dragoș Paul, Negreș, Simona
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.07.2023; MDPI
• Subjects: Antidiabetics; antihyperalgesic; Bioethics; Blood sugar; Blood vessels; Chronic illnesses; Chronic pain; combination; Cytokines; Diabetes; Diabetic neuropathies; Diabetic neuropathy; Drug withdrawal; Glucose; Health aspects; Hyperalgesia; Kinases; Metabolism; Metformin; Narcotics; Nitric oxide; Pathology; Pathophysiology; Pharmacy; Sildenafil; Tumor necrosis factor; Tumor necrosis factor-TNF; Type 2 diabetes; Canada; Germany; Romania; Bucharest Romania; Hungary

Background and objectives: Worldwide, approximately 500 million people suffer from diabetes and at least 50% of these people develop neuropathy. Currently, therapeutic strategies for reducing diabetic neuropathy (DN)-associated pain are limited and have several side effects. The purpose of the study...