Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation – A systematic review of randomized trials, observational studies and case reports

• Published in: Vaccine Vol. 35; no. 9; pp. 1216 - 1226
• Main Authors: Croce, Evelina, Hatz, Christoph, Jonker, Emile F., Visser, L.G., Jaeger, Veronika K., Bühler, Silja
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2017; Elsevier Limited
• Subjects: Allergy and Immunology; Animal vaccines; Arthritis; BCG vaccine; Bone marrow; Bone Marrow Transplantation; case studies; Chicken pox; Chickenpox - prevention & control; Chickenpox Vaccine - administration & dosage; Chickenpox Vaccine - adverse effects; dexamethasone; Female; Humans; immune response; Immune System Diseases - drug therapy; Immune-mediated inflammatory disease; Immunogenicity; immunosuppression; Immunosuppressive Agents - therapeutic use; Immunosuppressive medication; Infant; Infections; Infectious diseases; Inflammation - drug therapy; Inflammatory diseases; Leukemia; Live vaccine; live vaccines; Lymphoma; Male; Measles; Measles - prevention & control; Measles-Mumps-Rubella Vaccine - administration & dosage; Measles-Mumps-Rubella Vaccine - adverse effects; Mumps; Mumps - prevention & control; Observational studies; Observational Studies as Topic; Organ Transplantation; Patients; Poliomyelitis; Pregnancy; Public health; Randomized Controlled Trials as Topic; Rheumatic diseases; risk; Rotavirus; Rubella; Rubella - prevention & control; Safety; seroconversion; Smallpox; Solid organ transplantation; Studies; Subject heading schemes; systematic review; Transplantation; Transplants & implants; tumor necrosis factors; Typhoid; typhoid fever; Vaccination; Vaccines; Vaccines, Attenuated - adverse effects; Vaccines, Combined - administration & dosage; Vaccines, Combined - adverse effects; Vector-borne diseases; Viruses; Yellow Fever; Yellow Fever Vaccine - administration & dosage; Yellow Fever Vaccine - adverse effects; Yellow fever virus; INF; VV; RCT; Immunosuppressive medication; HZV; Immune-mediated inflammatory disease; IBD; TCZ; SLE; YF; AEs; Bone-marrow transplantation; CSA; MTX; HZ; VZV; RTX; IFX; Solid organ transplantation; IMID; JIA; MS; BCG; MMF; BMT; YFV; GvHD; IVIG; RA; YEL-AVD; Live vaccine; MMR; SAE; TAC; SOT; TNFi; yellow fever vaccine-associated viscerotropic disease; infliximab; tumor necrosis factor inhibitor; tocilizumab; yellow fever vaccine; varicella vaccine; herpes zoster; rheumatoid arthritis; inflammatory bowel disease; mumps, measles, rubella; cyclosporine A; yellow fever; methotrexate; bone marrow transplantation; systemic lupus erythematosus; serious adverse event; herpes zoster vaccine; intravenous immunoglobulin; rituximab; multiple sclerosis; tacrolimus; adverse events; interferon; juvenile idiopathic arthritis; randomized controlled trial; Bacillus Calmette–Guérin; mycophenolate-mofetil; varicella zoster virus; graft versus host disease

Live vaccines are generally contraindicated on immunosuppressive therapy due to safety concerns. However, data are limited to corroborate this practice. To estimate the safety of live vaccinations in patients with immune-mediated inflammatory diseases (IMID) or solid organ transplantation (SOT) on i...