Ictal SPECT statistical parametric mapping in temporal lobe epilepsy surgery

• Published in: Neurology Vol. 74; no. 1; p. 70
• Main Authors: Kazemi, N J, Worrell, G A, Stead, S M, Brinkmann, B H, Mullan, B P, O'Brien, T J, So, E L
• Format: Journal Article
• Language: English
• Published: United States 05.01.2010
• Subjects: Adolescent; Adult; Brain - diagnostic imaging; Brain - pathology; Brain - surgery; Brain Mapping; Cysteine - analogs & derivatives; Electroencephalography; Epilepsy, Temporal Lobe - classification; Epilepsy, Temporal Lobe - diagnostic imaging; Epilepsy, Temporal Lobe - pathology; Epilepsy, Temporal Lobe - surgery; Female; Functional Laterality - physiology; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Organotechnetium Compounds; Radiopharmaceuticals; Subtraction Technique; Time Factors; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Young Adult

Although subtraction ictal SPECT coregistered to MRI (SISCOM) is clinically useful in epilepsy surgery evaluation, it does not determine whether the ictal-interictal subtraction difference is statistically different from the expected random variation between 2 SPECT studies. We developed a statistic...