Redox control of viral carcinogenesis: The human papillomavirus paradigm

• Published in: Biochimica et biophysica acta Vol. 1850; no. 8; pp. 1622 - 1632
• Main Authors: Foppoli, Cesira, De Marco, Federico, Cini, Chiara, Perluigi, M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2015
• Subjects: Antioxidant systems; antioxidants; apoptosis; carcinogenesis; Cervical cancer; enzymes; Female; homeostasis; Human papillomavirus; Humans; microRNA; MicroRNAs - genetics; Models, Biological; Oncogene Proteins, Viral - metabolism; oncogenes; oxidants; oxidation; Oxidation-Reduction; Oxidative stress; Papillomaviridae; Papillomaviridae - metabolism; Papillomaviridae - physiology; Papillomavirus Infections - genetics; Papillomavirus Infections - metabolism; Papillomavirus Infections - virology; phenotype; Reactive Oxygen Species - metabolism; Transcription factors; uterine cervical neoplasms; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - virology; women; Oxidative stress; Human papillomavirus; Transcription factors; Cervical cancer; Antioxidant systems

Cervical cancer is the second most common neoplastic disease among women worldwide. The initiating event of such cancer is the infection with certain types of human papillomavirus (HPV), a very common condition in the general population. However, the majority of HPV infections is subclinical and tra...