Exercise-Induced Systemic Venous Hypertension in the Fontan Circulation

• Published in: The American journal of cardiology Vol. 117; no. 10; pp. 1667 - 1671
• Main Authors: Navaratnam, Devaraj, Fitzsimmons, Samantha, Grocott, Michael, Rossiter, Harry B., Emmanuel, Yaso, Diller, Gerard-Paul, Gordon-Walker, Timothy, Jack, Sandy, Sheron, Nick, Pappachan, John, Pratap, Jayant Nick, Vettukattil, Joseph J., Veldtman, Gruschen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2016; Elsevier Limited
• Subjects: Adult; Age; Cardiac Output; Cardiovascular; Central Venous Pressure; Exercise Test - adverse effects; Exercise Tolerance - physiology; Female; Fontan Procedure - adverse effects; Heart Defects, Congenital - physiopathology; Heart Defects, Congenital - surgery; Heart failure; Humans; Hypertension; Hypertension - epidemiology; Hypertension - etiology; Hypertension - physiopathology; Liver; Male; Metabolism; Physiology; Pulmonary arteries; R&D; Research & development; Studies; United States - epidemiology; Veins & arteries; Young Adult

Increasingly end-organ injury is being demonstrated late after institution of the Fontan circulation, particularly liver fibrosis and cirrhosis. The exact mechanisms for these late phenomena remain largely elusive. Hypothesizing that exercise induces precipitous systemic venous hypertension and insu...