Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms
ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood. Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively...
Saved in:
Published in | Oncogene Vol. 28; no. 10; pp. 1309 - 1319 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
12.03.2009
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood. Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively recognizes the ectodomain of cleavable ErbB4 JM-a isoforms both
in vitro
and
in vivo
. mAb 1479 was used to analyse ErbB4 JM-a expression and ectodomain shedding in a series of 17 matched breast cancer/histologically normal peripheral breast tissue pairs. ErbB4 ectodomain was observed in 75% of tumors expressing ErbB4 but only in 18% of normal breast tissue samples expressing ErbB4. Difference in the relative quantity of ErbB4 ectodomain between normal and tumor tissue pairs was statistically significant (
P
=0.015). Treatment with mAb 1479 suppressed ErbB4 function by inhibiting ErbB4 tyrosine phosphorylation and ectodomain shedding, and by stimulating ErbB4 downregulation and ubiquitination. mAb 1479 suppressed both anchorage-dependent and -independent growth of human breast cancer cell lines that naturally express cleavable ErbB4 JM-a. These findings indicate that ErbB4 ectodomain shedding is enhanced in breast cancer tissue
in vivo
, and that mAb 1479 represents a potential drug candidate that suppresses breast cancer cell growth by selectively binding cleavable ErbB4 isoforms. |
---|---|
AbstractList | ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood. Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively recognizes the ectodomain of cleavable ErbB4 JM-a isoforms both in vitro and in vivo. mAb 1479 was used to analyse ErbB4 JM-a expression and ectodomain shedding in a series of 17 matched breast cancer/histologically normal peripheral breast tissue pairs. ErbB4 ectodomain was observed in 75% of tumors expressing ErbB4 but only in 18% of normal breast tissue samples expressing ErbB4. Difference in the relative quantity of ErbB4 ectodomain between normal and tumor tissue pairs was statistically significant (P=0.015). Treatment with mAb 1479 suppressed ErbB4 function by inhibiting ErbB4 tyrosine phosphorylation and ectodomain shedding, and by stimulating ErbB4 downregulation and ubiquitination. mAb 1479 suppressed both anchorage-dependent and -independent growth of human breast cancer cell lines that naturally express cleavable ErbB4 JM-a. These findings indicate that ErbB4 ectodomain shedding is enhanced in breast cancer tissue in vivo, and that mAb 1479 represents a potential drug candidate that suppresses breast cancer cell growth by selectively binding cleavable ErbB4 isoforms. [PUBLICATION ABSTRACT] ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood. Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively recognizes the ectodomain of cleavable ErbB4 JM-a isoforms both in vitro and in vivo. mAb 1479 was used to analyse ErbB4 JM-a expression and ectodomain shedding in a series of 17 matched breast cancer/histologically normal peripheral breast tissue pairs. ErbB4 ectodomain was observed in 75% of tumors expressing ErbB4 but only in 18% of normal breast tissue samples expressing ErbB4. Difference in the relative quantity of ErbB4 ectodomain between normal and tumor tissue pairs was statistically significant (P = 0.015). Treatment with mAb 1479 suppressed ErbB4 function by inhibiting ErbB4 tyrosine phosphorylation and ectodomain shedding, and by stimulating ErbB4 downregulation and ubiquitination. mAb 1479 suppressed both anchorage-dependent and -independent growth of human breast cancer cell lines that naturally express cleavable ErbB4 JM-a. These findings indicate that ErbB4 ectodomain shedding is enhanced in breast cancer tissue in vivo, and that mAb 1479 represents a potential drug candidate that suppresses breast cancer cell growth by selectively binding cleavable ErbB4 isoforms. ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood. Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively recognizes the ectodomain of cleavable ErbB4 JM-a isoforms both in vitro and in vivo . mAb 1479 was used to analyse ErbB4 JM-a expression and ectodomain shedding in a series of 17 matched breast cancer/histologically normal peripheral breast tissue pairs. ErbB4 ectodomain was observed in 75% of tumors expressing ErbB4 but only in 18% of normal breast tissue samples expressing ErbB4. Difference in the relative quantity of ErbB4 ectodomain between normal and tumor tissue pairs was statistically significant ( P =0.015). Treatment with mAb 1479 suppressed ErbB4 function by inhibiting ErbB4 tyrosine phosphorylation and ectodomain shedding, and by stimulating ErbB4 downregulation and ubiquitination. mAb 1479 suppressed both anchorage-dependent and -independent growth of human breast cancer cell lines that naturally express cleavable ErbB4 JM-a. These findings indicate that ErbB4 ectodomain shedding is enhanced in breast cancer tissue in vivo , and that mAb 1479 represents a potential drug candidate that suppresses breast cancer cell growth by selectively binding cleavable ErbB4 isoforms. ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis, however, remains poorly understood. Here, we describe characterization of a monoclonal antibody (mAb 1479) that selectively recognizes the ectodomain of cleavable ErbB4 JM-a isoforms both in vitro and in vivo. mAb 1479 was used to analyse ErbB4 JM-a expression and ectodomain shedding in a series of 17 matched breast cancer/histologically normal peripheral breast tissue pairs. ErbB4 ectodomain was observed in 75% of tumors expressing ErbB4 but only in 18% of normal breast tissue samples expressing ErbB4. Difference in the relative quantity of ErbB4 ectodomain between normal and tumor tissue pairs was statistically significant (P = 0.015). Treatment with mAb 1479 suppressed ErbB4 function by inhibiting ErbB4 tyrosine phosphorylation and ectodomain shedding, and by stimulating ErbB4 downregulation and ubiquitination. mAb 1479 suppressed both anchorage-dependent and -independent growth of human breast cancer cell lines that naturally express cleavable ErbB4 JM-a. These findings indicate that ErbB4 ectodomain shedding is enhanced in breast cancer tissue in vivo, and that mAb 1479 represents a potential drug candidate that suppresses breast cancer cell growth by selectively binding cleavable ErbB4 isoforms. doi:10.1038/onc.2008.481; published online 19 January 2009 Keywords: ectodomain shedding; EGFR; HER4; neuregulins; therapeutic antibodies |
Audience | Academic |
Author | Bald, L Elenius, K Sliwkowski, M X Hollmén, M Määttä, J A |
Author_xml | – sequence: 1 givenname: M surname: Hollmén fullname: Hollmén, M organization: Department of Medical Biochemistry and Genetics, Medicity Research Laboratories, University of Turku, Turku Graduate School of Biomedical Sciences – sequence: 2 givenname: J A surname: Määttä fullname: Määttä, J A organization: Department of Medical Biochemistry and Genetics, Medicity Research Laboratories, University of Turku – sequence: 3 givenname: L surname: Bald fullname: Bald, L organization: Genentech Inc – sequence: 4 givenname: M X surname: Sliwkowski fullname: Sliwkowski, M X organization: Genentech Inc – sequence: 5 givenname: K surname: Elenius fullname: Elenius, K email: klaus.elenius@utu.fi organization: Department of Medical Biochemistry and Genetics, Medicity Research Laboratories, University of Turku, Department of Oncology, Turku University Hospital |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21299649$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19151766$$D View this record in MEDLINE/PubMed |
BookMark | eNqF0k1v1DAQBmALFdFt4cYZWaByIsvY8Ud8LFULSJU40HvkOPbiKrEXOynaf4-jXXUFokI-RHIez3iS9wydhBgsQq8JrAnUzccYzJoCNGvWkGdoRZgUFeeKnaAVKA6VojU9RWc53wOAVEBfoFOiCCdSiBXqv8_bbbI5-xhwdLhLVucJGx2MTdjYYcCbFH9NP3C3wxqPMUQzxKAHrMPku9jv8KTTxk4-bLAZrH7Q3WDxdeo-MexzdDGN-SV67vSQ7avD8xzd3VzfXX2pbr99_np1eVsZXvOpkpQqqB11Pe913SvJle2tA65dwwQD0A0YsB1x0lChGi4E9ETzjhAjeVefo_f7stsUf842T-3o8zKCDjbOuRUSKOGq_i-kwOpGSVXgu7_gfZxTmb4YwUjdSMabot4-qaisBRFCHEtt9GBbH1yckjZL3_aSKEE4pUCLWv9DldXb0Zvy450v-38c-LA_YFLMOVnXbpMfddq1BNolH23JR7vkoy35KPzN4apzN9r-iA-BKODiAHQ2enCpBMHnR0cJVUqw5ctUe5fLq7Cx6TjzE43x3gc9zck-FixoMQv5Dbg726E |
CODEN | ONCNES |
CitedBy_id | crossref_primary_10_1177_107327481702400115 crossref_primary_10_1091_mbc_e10_04_0332 crossref_primary_10_2217_fon_14_45 crossref_primary_10_1111_cas_14458 crossref_primary_10_1186_s12885_015_1265_2 crossref_primary_10_1371_journal_pone_0102388 crossref_primary_10_1017_S1470903109990216 crossref_primary_10_1038_s41388_018_0465_z crossref_primary_10_1186_1756_9966_33_10 crossref_primary_10_1016_j_nbd_2018_12_021 crossref_primary_10_1002_jcb_26488 crossref_primary_10_1371_journal_pone_0146100 crossref_primary_10_3390_cancers11121826 crossref_primary_10_1158_0008_5472_CAN_12_2052 crossref_primary_10_1038_bjc_2013_247 crossref_primary_10_1007_s13258_015_0336_8 crossref_primary_10_1152_ajprenal_00607_2016 crossref_primary_10_1371_journal_pone_0033009 crossref_primary_10_18632_oncotarget_1232 crossref_primary_10_18632_oncotarget_2002 crossref_primary_10_1093_carcin_bgv049 crossref_primary_10_1007_s13402_020_00499_4 crossref_primary_10_1186_s13058_014_0501_z crossref_primary_10_18632_oncotarget_26867 crossref_primary_10_1016_j_ctrv_2022_102436 crossref_primary_10_1038_labinvest_2010_117 crossref_primary_10_1038_nri2744 crossref_primary_10_1002_cncr_27496 crossref_primary_10_1186_s13058_018_1072_1 crossref_primary_10_1016_j_breast_2016_05_007 crossref_primary_10_1371_journal_pone_0039413 crossref_primary_10_1111_his_12024 crossref_primary_10_1016_j_breast_2018_10_002 crossref_primary_10_3390_molecules26237376 crossref_primary_10_2217_fon_09_144 crossref_primary_10_1016_j_cellsig_2022_110401 crossref_primary_10_1186_1471_2407_13_437 |
Cites_doi | 10.1073/pnas.90.5.1746 10.1126/science.1065412 10.2174/187221508783406602 10.1038/35101072 10.1093/emboj/cdg111 10.1038/nature01392 10.1091/mbc.e02-10-0639 10.1074/jbc.271.7.3884 10.1034/j.1600-0854.2002.31006.x 10.1083/jcb.200212085 10.1016/S1535-6108(04)00083-2 10.1038/sj.onc.1210501 10.1074/jbc.275.12.8641 10.3727/0965040042707907 10.1038/sj.onc.1204082 10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7 10.1158/0008-5472.CAN-04-3150 10.1093/protein/3.6.547 10.1038/nature07423 10.1074/jbc.271.31.18989 10.1007/s10911-008-9079-3 10.1074/jbc.M305597200 10.1016/j.yexcr.2007.03.042 10.1002/path.1370 10.1074/jbc.M110371200 10.1091/mbc.e05-05-0402 10.1016/S1535-6108(02)00097-1 10.1096/fj.06-7925com 10.1016/S1050-1738(01)00065-2 10.1038/nrc1609 10.1073/pnas.83.11.3825 10.1074/jbc.M302111200 10.1126/science.3798106 10.1073/pnas.0708333105 10.1074/jbc.272.42.26761 10.1074/jbc.275.14.10379 10.1016/j.cell.2006.09.013 |
ContentType | Journal Article |
Copyright | Macmillan Publishers Limited 2009 2009 INIST-CNRS COPYRIGHT 2009 Nature Publishing Group Copyright Nature Publishing Group Mar 12, 2009 Macmillan Publishers Limited 2009. |
Copyright_xml | – notice: Macmillan Publishers Limited 2009 – notice: 2009 INIST-CNRS – notice: COPYRIGHT 2009 Nature Publishing Group – notice: Copyright Nature Publishing Group Mar 12, 2009 – notice: Macmillan Publishers Limited 2009. |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7P MBDVC P64 PQEST PQQKQ PQUKI PRINS Q9U RC3 7X8 |
DOI | 10.1038/onc.2008.481 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Research Library Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic AIDS and Cancer Research Abstracts Research Library Prep |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Biology |
EISSN | 1476-5594 |
EndPage | 1319 |
ExternalDocumentID | 1668161821 A196152202 10_1038_onc_2008_481 19151766 21299649 onc2008481 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Finland |
GeographicLocations_xml | – name: Finland |
GroupedDBID | - -Q- 0R 123 1AW 29N 2WC 39C 3O- 3V. 4.4 53G 5RE 70F 7X7 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AADWK AAPBV AAYJO AAZLF ABAWZ ABDBF ABFLS ABGIJ ABPTK ABUWG ACGFS ACKTT ACPRK ADBBV ADHDB ADQMX AEDAW AEJRE AENEX AEXYK AFKRA AFSHS AGEZK AHGBK AHMBA AHSBF AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBAFP BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG COF CS3 DIK DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EPL ESX F5P FDQFY FEDTE FERAY FIZPM FRP FSGXE FYUFA GNUQQ GUQSH HCIFZ HVGLF HZ IAO IHR INH INR IPNFZ ITC JSO KQ8 L7B LK8 M0L M1P M2O M7P N9A NAO O9- OK1 OVD P2P PADUT PQEST PQQKQ PQUKI PRINS PROAC PSQYO Q- Q2X RIG RNS RNT RNTTT SNX SNYQT SV3 SWTZT TAOOD TBHMF TDRGL TSG TUS W2D WH7 ZA5 --- 0R~ 36B 406 AANZL AAWBL ABAKF ABJNI ABLJU ABZZP ACAOD ACGFO ACMJI ACRQY ACZOJ ADFRT AEMSY AEVLU AFBBN AGHAI AGQEE AILAN ALIPV AMYLF CCPQU DNIVK DPUIP EMOBN HMCUK HZ~ IWAJR JZLTJ NQJWS NXXTH SOHCF SRMVM TEORI UKHRP ~8M .55 .GJ 08R AATNV AAUGY AAYFA ABEFU ACBMV ACBRV ACBYP ACIGE ACTTH ACVWB ADMDM ADYYL AEFTE AFFNX AFNRJ AGGBP AJCLW AJDOV AMRJV BAWUL IQODW NYICJ TR2 UDS X7M ZXP AAYZH CGR CUY CVF ECM EIF NPM AAYXX CITATION FIGPU 7TM 7TO 7U9 7XB 8FD 8FK FR3 H94 K9. MBDVC P64 Q9U RC3 7X8 |
ID | FETCH-LOGICAL-c535t-722903f2fd5da3d9759edef05af846400a80c0eb1f7c26985660d1a5b11c75b3 |
IEDL.DBID | BENPR |
ISSN | 0950-9232 |
IngestDate | Fri Aug 16 09:30:19 EDT 2024 Sun Sep 29 07:38:06 EDT 2024 Thu Oct 10 20:32:03 EDT 2024 Thu Oct 10 15:59:23 EDT 2024 Fri Feb 23 00:21:38 EST 2024 Tue Feb 06 05:23:10 EST 2024 Fri Sep 27 02:37:11 EDT 2024 Tue Oct 15 23:35:04 EDT 2024 Sun Oct 22 16:07:07 EDT 2023 Fri Oct 11 20:47:28 EDT 2024 Tue Jun 15 14:05:32 EDT 2021 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Keywords | ectodomain shedding therapeutic antibodies neuregulins EGFR HER4 Molecular form Breast disease Targeting Growth Suppression Breast cancer Malignant tumor Monoclonal antibody Carcinogenesis Mammary gland diseases Neuregulin Cancer |
Language | English |
License | CC BY 4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c535t-722903f2fd5da3d9759edef05af846400a80c0eb1f7c26985660d1a5b11c75b3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | http://dx.doi.org/10.1038/onc.2008.481 |
PMID | 19151766 |
PQID | 227361666 |
PQPubID | 36330 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_67021593 proquest_miscellaneous_20438979 proquest_journals_2641387458 proquest_journals_227361666 gale_infotracmisc_A196152202 gale_infotracacademiconefile_A196152202 crossref_primary_10_1038_onc_2008_481 pubmed_primary_19151766 pascalfrancis_primary_21299649 springer_journals_10_1038_onc_2008_481 nature_primary_onc2008481 |
ProviderPackageCode | AEDAW AAZLF -Q- AADWK AAYJO 70F ADQMX EE. RNTTT SWTZT ABGIJ RNT AHGBK NAO |
PublicationCentury | 2000 |
PublicationDate | 3-12-2009 |
PublicationDateYYYYMMDD | 2009-03-12 |
PublicationDate_xml | – month: 03 year: 2009 text: 3-12-2009 day: 12 |
PublicationDecade | 2000 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: Basingstoke – name: England – name: New York |
PublicationTitle | Oncogene |
PublicationTitleAbbrev | Oncogene |
PublicationTitleAlternate | Oncogene |
PublicationYear | 2009 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
References | Carter, P 2001; 1 Cheng, QC, Tikhomirov, O, Zhou, W, Carpenter, G 2003; 278 Sundvall, M, Iljin, K, Kilpinen, S, Sara, H, Kallioniemi, O, Elenius, K 2008a; 13 Gilbertson, RJ, Perry, RH, Kelly, PJ, Pearson, AD, Lunec, J 1997; 57 Rio, C, Buxbaum, JD, Peschon, JJ, Corfas, G 2000; 275 Schlessinger, J, Lemmon, MA 2006; 127 Mendelsohn, J, Baselga, J 2000; 19 Sundvall, M, Korhonen, A, Paatero, I, Gaudio, E, Melino, G, Croce, C 2008b; 105 Kainulainen, V, Sundvall, M, Maatta, JA, Santiestevan, E, Klagsbrun, M, Elenius, K 2000; 275 Witton, CJ, Reeves, JR, Going, JJ, Cooke, TG, Bartlett, JM 2003; 200 Ding, L, Getz, G, Wheeler, D, Mardis, E, McLellan, M, Cibulskis, K 2008; 455 Komuro, A, Nagai, M, Navin, NE, Sudol, M 2003; 278 Määttä, JA, Sundvall, M, Junttila, TT, Peri, L, Laine, VJ, Isola, J 2006; 17 Gomes, AQ, Ali, BR, Ramalho, JS, Godfrey, RF, Barral, DC, Hume, AN 2003; 14 Sundvall, M, Peri, L, Maatta, JA, Tvorogov, D, Paatero, I, Savisalo, M 2007; 26 Vecchi, M, Baulida, J, Carpenter, G 1996; 271 Katz, M, Shtiegman, K, Tal-Or, P, Yakir, L, Mosesson, Y, Harari, D 2002; 3 Hynes, NE, Lane, HA 2005; 5 Slamon, DJ, Clark, GM, Wong, SG, Levin, WJ, Ullrich, A, McGuire, WL 1987; 235 Iivanainen, E, Paatero, I, Heikkinen, SM, Junttila, TT, Cao, R, Klint, P 2007; 313 Molina, MA, Codony-Servat, J, Albanell, J, Rojo, F, Arribas, J, Baselga, J 2001; 61 Srinivasan, R, Poulsom, R, Hurst, HC, Gullick, WJ 1998; 185 Sunada, H, Magun, BE, Mendelsohn, J, MacLeod, CL 1986; 83 Furger, C, Fiddes, RJ, Quinn, DI, Bova, RJ, Daly, RJ, Sutherland, RL 1998; 58 Haugen, DR, Akslen, LA, Varhaug, JE, Lillehaug, JR 1996; 56 Klapper, LN, Waterman, H, Sela, M, Yarden, Y 2000; 60 Bao, J, Wolpowitz, D, Role, LW, Talmage, DA 2003; 161 Elenius, K, Corfas, G, Paul, S, Choi, CJ, Rio, C, Plowman, GD 1997; 272 Agus, DB, Akita, RW, Fox, WD, Lewis, GD, Higgins, B, Pisacane, PI 2002; 2 Junttila, TT, Laato, M, Vahlberg, T, Soderstrom, KO, Visakorpi, T, Isola, J 2003; 9 Junttila, TT, Sundvall, M, Maatta, JA, Elenius, K 2000; 10 Paatero, I, Elenius, K 2008; 2 Borrell-Pages, M, Rojo, F, Albanell, J, Baselga, J, Arribas, J 2003; 22 Srinivasan, R, Benton, E, McCormick, F, Thomas, H, Gullick, WJ 1999; 5 Prewett, M, Rothman, M, Waksal, H, Feldman, M, Bander, NH, Hicklin, DJ 1998; 4 Franklin, MC, Carey, KD, Vajdos, FF, Leahy, DJ, de Vos, AM, Sliwkowski, MX 2004; 5 Ni, CY, Murphy, MP, Golde, TE, Carpenter, G 2001; 294 Lee, HJ, Jung, KM, Huang, YZ, Bennett, LB, Lee, JS, Mei, L 2002; 277 Paborsky, LR, Fendly, BM, Fisher, KL, Lawn, RM, Marks, BJ, McCray, G 1990; 3 Junttila, TT, Sundvall, M, Lundin, M, Lundin, J, Tanner, M, Harkonen, P 2005; 65 Zhang, K, Sun, J, Liu, N, Wen, D, Chang, D, Thomason, A 1996; 271 Cho, HS, Mason, K, Ramyar, KX, Stanley, AM, Gabelli, SB, Denney, DW 2003; 421 Plowman, GD, Culouscou, JM, Whitney, GS, Green, JM, Carlton, GW, Foy, L 1993; 90 Gilbertson, RJ, Bentley, L, Hernan, R, Junttila, TT, Frank, AJ, Haapasalo, H 2002; 8 Gilmore, JL, Riese, DJ 2004; 14 Omerovic, J, Santangelo, L, Puggioni, E, Marrocco, J, Dall'Armi, C, Palumbo, C 2007; 21 Paborsky, Fendly, Fisher, Lawn, Marks, McCray (CR32) 1990; 3 Vecchi, Baulida, Carpenter (CR44) 1996; 271 Iivanainen, Paatero, Heikkinen, Junttila, Cao, Klint (CR17) 2007; 313 Gomes, Ali, Ramalho, Godfrey, Barral, Hume (CR14) 2003; 14 Haugen, Akslen, Varhaug, Lillehaug (CR15) 1996; 56 Kainulainen, Sundvall, Maatta, Santiestevan, Klagsbrun, Elenius (CR21) 2000; 275 Sundvall, Peri, Maatta, Tvorogov, Paatero, Savisalo (CR43) 2007; 26 Bao, Wolpowitz, Role, Talmage (CR2) 2003; 161 Carter (CR4) 2001; 1 Ni, Murphy, Golde, Carpenter (CR29) 2001; 294 Schlessinger, Lemmon (CR36) 2006; 127 Cheng, Tikhomirov, Zhou, Carpenter (CR5) 2003; 278 Katz, Shtiegman, Tal-Or, Yakir, Mosesson, Harari (CR22) 2002; 3 Prewett, Rothman, Waksal, Feldman, Bander, Hicklin (CR34) 1998; 4 Gilmore, Riese (CR13) 2004; 14 Plowman, Culouscou, Whitney, Green, Carlton, Foy (CR33) 1993; 90 Mendelsohn, Baselga (CR27) 2000; 19 Ding, Getz, Wheeler, Mardis, McLellan, Cibulskis (CR7) 2008; 455 Määttä, Sundvall, Junttila, Peri, Laine, Isola (CR26) 2006; 17 Slamon, Clark, Wong, Levin, Ullrich, McGuire (CR37) 1987; 235 Omerovic, Santangelo, Puggioni, Marrocco, Dall'Armi, Palumbo (CR30) 2007; 21 Rio, Buxbaum, Peschon, Corfas (CR35) 2000; 275 Furger, Fiddes, Quinn, Bova, Daly, Sutherland (CR10) 1998; 58 Hynes, Lane (CR16) 2005; 5 Cho, Mason, Ramyar, Stanley, Gabelli, Denney (CR6) 2003; 421 Junttila, Sundvall, Maatta, Elenius (CR20) 2000; 10 Paatero, Elenius (CR31) 2008; 2 Sundvall, Iljin, Kilpinen, Sara, Kallioniemi, Elenius (CR41) 2008; 13 Komuro, Nagai, Navin, Sudol (CR24) 2003; 278 Molina, Codony-Servat, Albanell, Rojo, Arribas, Baselga (CR28) 2001; 61 Srinivasan, Poulsom, Hurst, Gullick (CR39) 1998; 185 Elenius, Corfas, Paul, Choi, Rio, Plowman (CR8) 1997; 272 Gilbertson, Perry, Kelly, Pearson, Lunec (CR12) 1997; 57 Junttila, Sundvall, Lundin, Lundin, Tanner, Harkonen (CR19) 2005; 65 Agus, Akita, Fox, Lewis, Higgins, Pisacane (CR1) 2002; 2 Sunada, Magun, Mendelsohn, MacLeod (CR40) 1986; 83 Lee, Jung, Huang, Bennett, Lee, Mei (CR25) 2002; 277 Borrell-Pages, Rojo, Albanell, Baselga, Arribas (CR3) 2003; 22 Sundvall, Korhonen, Paatero, Gaudio, Melino, Croce (CR42) 2008; 105 Srinivasan, Benton, McCormick, Thomas, Gullick (CR38) 1999; 5 Franklin, Carey, Vajdos, Leahy, de Vos, Sliwkowski (CR9) 2004; 5 Junttila, Laato, Vahlberg, Soderstrom, Visakorpi, Isola (CR18) 2003; 9 Witton, Reeves, Going, Cooke, Bartlett (CR45) 2003; 200 Gilbertson, Bentley, Hernan, Junttila, Frank, Haapasalo (CR11) 2002; 8 Klapper, Waterman, Sela, Yarden (CR23) 2000; 60 Zhang, Sun, Liu, Wen, Chang, Thomason (CR46) 1996; 271 M Borrell-Pages (BFonc2008481_CR3) 2003; 22 J Schlessinger (BFonc2008481_CR36) 2006; 127 DJ Slamon (BFonc2008481_CR37) 1987; 235 DR Haugen (BFonc2008481_CR15) 1996; 56 J Omerovic (BFonc2008481_CR30) 2007; 21 GD Plowman (BFonc2008481_CR33) 1993; 90 CY Ni (BFonc2008481_CR29) 2001; 294 RJ Gilbertson (BFonc2008481_CR11) 2002; 8 RJ Gilbertson (BFonc2008481_CR12) 1997; 57 TT Junttila (BFonc2008481_CR18) 2003; 9 M Sundvall (BFonc2008481_CR43) 2007; 26 H Sunada (BFonc2008481_CR40) 1986; 83 K Zhang (BFonc2008481_CR46) 1996; 271 J Bao (BFonc2008481_CR2) 2003; 161 M Katz (BFonc2008481_CR22) 2002; 3 M Prewett (BFonc2008481_CR34) 1998; 4 C Furger (BFonc2008481_CR10) 1998; 58 K Elenius (BFonc2008481_CR8) 1997; 272 LN Klapper (BFonc2008481_CR23) 2000; 60 L Ding (BFonc2008481_CR7) 2008; 455 TT Junttila (BFonc2008481_CR20) 2000; 10 MC Franklin (BFonc2008481_CR9) 2004; 5 V Kainulainen (BFonc2008481_CR21) 2000; 275 I Paatero (BFonc2008481_CR31) 2008; 2 AQ Gomes (BFonc2008481_CR14) 2003; 14 R Srinivasan (BFonc2008481_CR39) 1998; 185 DB Agus (BFonc2008481_CR1) 2002; 2 JL Gilmore (BFonc2008481_CR13) 2004; 14 M Vecchi (BFonc2008481_CR44) 1996; 271 R Srinivasan (BFonc2008481_CR38) 1999; 5 QC Cheng (BFonc2008481_CR5) 2003; 278 C Rio (BFonc2008481_CR35) 2000; 275 CJ Witton (BFonc2008481_CR45) 2003; 200 TT Junttila (BFonc2008481_CR19) 2005; 65 HJ Lee (BFonc2008481_CR25) 2002; 277 MA Molina (BFonc2008481_CR28) 2001; 61 P Carter (BFonc2008481_CR4) 2001; 1 E Iivanainen (BFonc2008481_CR17) 2007; 313 JA Määttä (BFonc2008481_CR26) 2006; 17 NE Hynes (BFonc2008481_CR16) 2005; 5 M Sundvall (BFonc2008481_CR41) 2008; 13 HS Cho (BFonc2008481_CR6) 2003; 421 LR Paborsky (BFonc2008481_CR32) 1990; 3 A Komuro (BFonc2008481_CR24) 2003; 278 M Sundvall (BFonc2008481_CR42) 2008; 105 J Mendelsohn (BFonc2008481_CR27) 2000; 19 |
References_xml | – volume: 278 start-page: 33334 year: 2003 end-page: 33341 article-title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus publication-title: J Biol Chem contributor: fullname: Sudol, M – volume: 17 start-page: 67 year: 2006 end-page: 79 article-title: Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth publication-title: Mol Biol Cell contributor: fullname: Isola, J – volume: 5 start-page: 317 year: 2004 end-page: 328 article-title: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex publication-title: Cancer Cell contributor: fullname: Sliwkowski, MX – volume: 185 start-page: 236 year: 1998 end-page: 245 article-title: Expression of the c-erbB-4 HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types publication-title: J Pathol contributor: fullname: Gullick, WJ – volume: 14 start-page: 1882 year: 2003 end-page: 1899 article-title: Membrane targeting of Rab GTPases is influenced by the prenylation motif publication-title: Mol Biol Cell contributor: fullname: Hume, AN – volume: 275 start-page: 8641 year: 2000 end-page: 8649 article-title: A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis publication-title: J Biol Chem contributor: fullname: Elenius, K – volume: 127 start-page: 45 year: 2006 end-page: 48 article-title: Nuclear signaling by receptor tyrosine kinases: the first robin of spring publication-title: Cell contributor: fullname: Lemmon, MA – volume: 19 start-page: 6550 year: 2000 end-page: 6565 article-title: The EGF receptor family as targets for cancer therapy publication-title: Oncogene contributor: fullname: Baselga, J – volume: 200 start-page: 290 year: 2003 end-page: 297 article-title: Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer publication-title: J Pathol contributor: fullname: Bartlett, JM – volume: 3 start-page: 547 year: 1990 end-page: 553 article-title: Mammalian cell transient expression of tissue factor for the production of antigen publication-title: Protein Eng contributor: fullname: McCray, G – volume: 294 start-page: 2179 year: 2001 end-page: 2181 article-title: gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase publication-title: Science contributor: fullname: Carpenter, G – volume: 10 start-page: 304 year: 2000 end-page: 310 article-title: Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants publication-title: Trends Cardiovasc Med contributor: fullname: Elenius, K – volume: 61 start-page: 4744 year: 2001 end-page: 4749 article-title: Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells publication-title: Cancer Res contributor: fullname: Baselga, J – volume: 90 start-page: 1746 year: 1993 end-page: 1750 article-title: Ligand-specific activation of HER4 p180erbB4, a fourth member of the epidermal growth factor receptor family publication-title: Proc Natl Acad Sci USA contributor: fullname: Foy, L – volume: 13 start-page: 259 year: 2008a end-page: 268 article-title: Role of ErbB4 in breast cancer publication-title: J Mammary Gland Biol Neoplasia contributor: fullname: Elenius, K – volume: 26 start-page: 6905 year: 2007 end-page: 6914 article-title: Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains publication-title: Oncogene contributor: fullname: Savisalo, M – volume: 83 start-page: 3825 year: 1986 end-page: 3829 article-title: Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation publication-title: Proc Natl Acad Sci USA contributor: fullname: MacLeod, CL – volume: 278 start-page: 38421 year: 2003 end-page: 38427 article-title: Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment publication-title: J Biol Chem contributor: fullname: Carpenter, G – volume: 5 start-page: 2877 year: 1999 end-page: 2883 article-title: Expression of the c-erbB-3 HER-3 and c-erbB-4 HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer publication-title: Clin Cancer Res contributor: fullname: Gullick, WJ – volume: 57 start-page: 3272 year: 1997 end-page: 3280 article-title: Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma publication-title: Cancer Res contributor: fullname: Lunec, J – volume: 2 start-page: 127 year: 2002 end-page: 137 article-title: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth publication-title: Cancer Cell contributor: fullname: Pisacane, PI – volume: 5 start-page: 341 year: 2005 end-page: 354 article-title: ERBB receptors and cancer: the complexity of targeted inhibitors publication-title: Nat Rev Cancer contributor: fullname: Lane, HA – volume: 272 start-page: 26761 year: 1997 end-page: 26768 article-title: A novel juxtamembrane domain isoform of HER4 ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester publication-title: J Biol Chem contributor: fullname: Plowman, GD – volume: 60 start-page: 3384 year: 2000 end-page: 3388 article-title: Tumor-inhibitory antibodies to HER-2 ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2 publication-title: Cancer Res contributor: fullname: Yarden, Y – volume: 65 start-page: 1384 year: 2005 end-page: 1393 article-title: Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells publication-title: Cancer Res contributor: fullname: Harkonen, P – volume: 271 start-page: 18989 year: 1996 end-page: 18995 article-title: Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation publication-title: J Biol Chem contributor: fullname: Carpenter, G – volume: 22 start-page: 1114 year: 2003 end-page: 1124 article-title: TACE is required for the activation of the EGFR by TGF-alpha in tumors publication-title: EMBO J contributor: fullname: Arribas, J – volume: 1 start-page: 118 year: 2001 end-page: 129 article-title: Improving the efficacy of antibody-based cancer therapies publication-title: Nat Rev Cancer contributor: fullname: Carter, P – volume: 58 start-page: 1773 year: 1998 end-page: 1778 article-title: Granulosa cell tumors express erbB4 and are sensitive to the cytotoxic action of heregulin-beta2 PE40 publication-title: Cancer Res contributor: fullname: Sutherland, RL – volume: 2 start-page: 27 year: 2008 end-page: 33 article-title: ErbB4 and its isoforms: patentable drug targets? publication-title: Recent Pat DNA Gene Seq contributor: fullname: Elenius, K – volume: 14 start-page: 589 year: 2004 end-page: 602 article-title: secErbB4-26 549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation publication-title: Oncol Res contributor: fullname: Riese, DJ – volume: 313 start-page: 2896 year: 2007 end-page: 2909 article-title: Intra- and extracellular signaling by endothelial neuregulin-1 publication-title: Exp Cell Res contributor: fullname: Klint, P – volume: 455 start-page: 1069 year: 2008 end-page: 1075 article-title: Somatic mutations affect key pathways in lung adenocarcinoma publication-title: Nature contributor: fullname: Cibulskis, K – volume: 9 start-page: 5346 year: 2003 end-page: 5357 article-title: Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients publication-title: Clin Cancer Res contributor: fullname: Isola, J – volume: 56 start-page: 1184 year: 1996 end-page: 1188 article-title: Expression of c-erbB-3 and c-erbB-4 proteins in papillary thyroid carcinomas publication-title: Cancer Res contributor: fullname: Lillehaug, JR – volume: 275 start-page: 10379 year: 2000 end-page: 10387 article-title: Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4 HER4 publication-title: J Biol Chem contributor: fullname: Corfas, G – volume: 3 start-page: 740 year: 2002 end-page: 751 article-title: Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4 publication-title: Traffic contributor: fullname: Harari, D – volume: 277 start-page: 6318 year: 2002 end-page: 6323 article-title: Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4 publication-title: J Biol Chem contributor: fullname: Mei, L – volume: 105 start-page: 4162 year: 2008b end-page: 4167 article-title: Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms publication-title: Proc Natl Acad Sci USA contributor: fullname: Croce, C – volume: 271 start-page: 3884 year: 1996 end-page: 3890 article-title: Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2 publication-title: J Biol Chem contributor: fullname: Thomason, A – volume: 8 start-page: 3054 year: 2002 end-page: 3064 article-title: ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease publication-title: Clin Cancer Res contributor: fullname: Haapasalo, H – volume: 161 start-page: 1133 year: 2003 end-page: 1141 article-title: Back signaling by the Nrg-1 intracellular domain publication-title: J Cell Biol contributor: fullname: Talmage, DA – volume: 235 start-page: 177 year: 1987 end-page: 182 article-title: Human breast cancer: correlation of relapse and survival with amplification of the HER-2 neu oncogene publication-title: Science contributor: fullname: McGuire, WL – volume: 21 start-page: 2849 year: 2007 end-page: 2862 article-title: The E3 ligase Aip4 Itch ubiquitinates and targets ErbB-4 for degradation publication-title: FASEB J contributor: fullname: Palumbo, C – volume: 4 start-page: 2957 year: 1998 end-page: 2966 article-title: Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice publication-title: Clin Cancer Res contributor: fullname: Hicklin, DJ – volume: 421 start-page: 756 year: 2003 end-page: 760 article-title: Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab publication-title: Nature contributor: fullname: Denney, DW – volume: 90 start-page: 1746 year: 1993 end-page: 1750 ident: CR33 article-title: Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.90.5.1746 contributor: fullname: Foy – volume: 294 start-page: 2179 year: 2001 end-page: 2181 ident: CR29 article-title: gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase publication-title: Science doi: 10.1126/science.1065412 contributor: fullname: Carpenter – volume: 2 start-page: 27 year: 2008 end-page: 33 ident: CR31 article-title: ErbB4 and its isoforms: patentable drug targets? publication-title: Recent Pat DNA Gene Seq doi: 10.2174/187221508783406602 contributor: fullname: Elenius – volume: 1 start-page: 118 year: 2001 end-page: 129 ident: CR4 article-title: Improving the efficacy of antibody-based cancer therapies publication-title: Nat Rev Cancer doi: 10.1038/35101072 contributor: fullname: Carter – volume: 61 start-page: 4744 year: 2001 end-page: 4749 ident: CR28 article-title: Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells publication-title: Cancer Res contributor: fullname: Baselga – volume: 5 start-page: 2877 year: 1999 end-page: 2883 ident: CR38 article-title: Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer publication-title: Clin Cancer Res contributor: fullname: Gullick – volume: 22 start-page: 1114 year: 2003 end-page: 1124 ident: CR3 article-title: TACE is required for the activation of the EGFR by TGF-alpha in tumors publication-title: EMBO J doi: 10.1093/emboj/cdg111 contributor: fullname: Arribas – volume: 421 start-page: 756 year: 2003 end-page: 760 ident: CR6 article-title: Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab publication-title: Nature doi: 10.1038/nature01392 contributor: fullname: Denney – volume: 14 start-page: 1882 year: 2003 end-page: 1899 ident: CR14 article-title: Membrane targeting of Rab GTPases is influenced by the prenylation motif publication-title: Mol Biol Cell doi: 10.1091/mbc.e02-10-0639 contributor: fullname: Hume – volume: 271 start-page: 3884 year: 1996 end-page: 3890 ident: CR46 article-title: Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2 publication-title: J Biol Chem doi: 10.1074/jbc.271.7.3884 contributor: fullname: Thomason – volume: 3 start-page: 740 year: 2002 end-page: 751 ident: CR22 article-title: Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4 publication-title: Traffic doi: 10.1034/j.1600-0854.2002.31006.x contributor: fullname: Harari – volume: 161 start-page: 1133 year: 2003 end-page: 1141 ident: CR2 article-title: Back signaling by the Nrg-1 intracellular domain publication-title: J Cell Biol doi: 10.1083/jcb.200212085 contributor: fullname: Talmage – volume: 5 start-page: 317 year: 2004 end-page: 328 ident: CR9 article-title: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex publication-title: Cancer Cell doi: 10.1016/S1535-6108(04)00083-2 contributor: fullname: Sliwkowski – volume: 26 start-page: 6905 year: 2007 end-page: 6914 ident: CR43 article-title: Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains publication-title: Oncogene doi: 10.1038/sj.onc.1210501 contributor: fullname: Savisalo – volume: 275 start-page: 8641 year: 2000 end-page: 8649 ident: CR21 article-title: A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis publication-title: J Biol Chem doi: 10.1074/jbc.275.12.8641 contributor: fullname: Elenius – volume: 14 start-page: 589 year: 2004 end-page: 602 ident: CR13 article-title: secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation publication-title: Oncol Res doi: 10.3727/0965040042707907 contributor: fullname: Riese – volume: 19 start-page: 6550 year: 2000 end-page: 6565 ident: CR27 article-title: The EGF receptor family as targets for cancer therapy publication-title: Oncogene doi: 10.1038/sj.onc.1204082 contributor: fullname: Baselga – volume: 4 start-page: 2957 year: 1998 end-page: 2966 ident: CR34 article-title: Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice publication-title: Clin Cancer Res contributor: fullname: Hicklin – volume: 185 start-page: 236 year: 1998 end-page: 245 ident: CR39 article-title: Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types publication-title: J Pathol doi: 10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7 contributor: fullname: Gullick – volume: 65 start-page: 1384 year: 2005 end-page: 1393 ident: CR19 article-title: Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-3150 contributor: fullname: Harkonen – volume: 3 start-page: 547 year: 1990 end-page: 553 ident: CR32 article-title: Mammalian cell transient expression of tissue factor for the production of antigen publication-title: Protein Eng doi: 10.1093/protein/3.6.547 contributor: fullname: McCray – volume: 455 start-page: 1069 year: 2008 end-page: 1075 ident: CR7 article-title: Somatic mutations affect key pathways in lung adenocarcinoma publication-title: Nature doi: 10.1038/nature07423 contributor: fullname: Cibulskis – volume: 271 start-page: 18989 year: 1996 end-page: 18995 ident: CR44 article-title: Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation publication-title: J Biol Chem doi: 10.1074/jbc.271.31.18989 contributor: fullname: Carpenter – volume: 56 start-page: 1184 year: 1996 end-page: 1188 ident: CR15 article-title: Expression of c-erbB-3 and c-erbB-4 proteins in papillary thyroid carcinomas publication-title: Cancer Res contributor: fullname: Lillehaug – volume: 13 start-page: 259 year: 2008 end-page: 268 ident: CR41 article-title: Role of ErbB4 in breast cancer publication-title: J Mammary Gland Biol Neoplasia doi: 10.1007/s10911-008-9079-3 contributor: fullname: Elenius – volume: 278 start-page: 33334 year: 2003 end-page: 33341 ident: CR24 article-title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus publication-title: J Biol Chem doi: 10.1074/jbc.M305597200 contributor: fullname: Sudol – volume: 313 start-page: 2896 year: 2007 end-page: 2909 ident: CR17 article-title: Intra- and extracellular signaling by endothelial neuregulin-1 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2007.03.042 contributor: fullname: Klint – volume: 8 start-page: 3054 year: 2002 end-page: 3064 ident: CR11 article-title: ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease publication-title: Clin Cancer Res contributor: fullname: Haapasalo – volume: 60 start-page: 3384 year: 2000 end-page: 3388 ident: CR23 article-title: Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2 publication-title: Cancer Res contributor: fullname: Yarden – volume: 200 start-page: 290 year: 2003 end-page: 297 ident: CR45 article-title: Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer publication-title: J Pathol doi: 10.1002/path.1370 contributor: fullname: Bartlett – volume: 57 start-page: 3272 year: 1997 end-page: 3280 ident: CR12 article-title: Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma publication-title: Cancer Res contributor: fullname: Lunec – volume: 277 start-page: 6318 year: 2002 end-page: 6323 ident: CR25 article-title: Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4 publication-title: J Biol Chem doi: 10.1074/jbc.M110371200 contributor: fullname: Mei – volume: 17 start-page: 67 year: 2006 end-page: 79 ident: CR26 article-title: Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth publication-title: Mol Biol Cell doi: 10.1091/mbc.e05-05-0402 contributor: fullname: Isola – volume: 2 start-page: 127 year: 2002 end-page: 137 ident: CR1 article-title: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00097-1 contributor: fullname: Pisacane – volume: 58 start-page: 1773 year: 1998 end-page: 1778 ident: CR10 article-title: Granulosa cell tumors express erbB4 and are sensitive to the cytotoxic action of heregulin-beta2/PE40 publication-title: Cancer Res contributor: fullname: Sutherland – volume: 21 start-page: 2849 year: 2007 end-page: 2862 ident: CR30 article-title: The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation publication-title: FASEB J doi: 10.1096/fj.06-7925com contributor: fullname: Palumbo – volume: 10 start-page: 304 year: 2000 end-page: 310 ident: CR20 article-title: Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants publication-title: Trends Cardiovasc Med doi: 10.1016/S1050-1738(01)00065-2 contributor: fullname: Elenius – volume: 5 start-page: 341 year: 2005 end-page: 354 ident: CR16 article-title: ERBB receptors and cancer: the complexity of targeted inhibitors publication-title: Nat Rev Cancer doi: 10.1038/nrc1609 contributor: fullname: Lane – volume: 83 start-page: 3825 year: 1986 end-page: 3829 ident: CR40 article-title: Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.11.3825 contributor: fullname: MacLeod – volume: 278 start-page: 38421 year: 2003 end-page: 38427 ident: CR5 article-title: Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment publication-title: J Biol Chem doi: 10.1074/jbc.M302111200 contributor: fullname: Carpenter – volume: 235 start-page: 177 year: 1987 end-page: 182 ident: CR37 article-title: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene publication-title: Science doi: 10.1126/science.3798106 contributor: fullname: McGuire – volume: 105 start-page: 4162 year: 2008 end-page: 4167 ident: CR42 article-title: Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0708333105 contributor: fullname: Croce – volume: 272 start-page: 26761 year: 1997 end-page: 26768 ident: CR8 article-title: A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester publication-title: J Biol Chem doi: 10.1074/jbc.272.42.26761 contributor: fullname: Plowman – volume: 275 start-page: 10379 year: 2000 end-page: 10387 ident: CR35 article-title: Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4 publication-title: J Biol Chem doi: 10.1074/jbc.275.14.10379 contributor: fullname: Corfas – volume: 127 start-page: 45 year: 2006 end-page: 48 ident: CR36 article-title: Nuclear signaling by receptor tyrosine kinases: the first robin of spring publication-title: Cell doi: 10.1016/j.cell.2006.09.013 contributor: fullname: Lemmon – volume: 9 start-page: 5346 year: 2003 end-page: 5357 ident: CR18 article-title: Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients publication-title: Clin Cancer Res contributor: fullname: Isola – volume: 9 start-page: 5346 year: 2003 ident: BFonc2008481_CR18 publication-title: Clin Cancer Res contributor: fullname: TT Junttila – volume: 235 start-page: 177 year: 1987 ident: BFonc2008481_CR37 publication-title: Science doi: 10.1126/science.3798106 contributor: fullname: DJ Slamon – volume: 56 start-page: 1184 year: 1996 ident: BFonc2008481_CR15 publication-title: Cancer Res contributor: fullname: DR Haugen – volume: 105 start-page: 4162 year: 2008 ident: BFonc2008481_CR42 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0708333105 contributor: fullname: M Sundvall – volume: 61 start-page: 4744 year: 2001 ident: BFonc2008481_CR28 publication-title: Cancer Res contributor: fullname: MA Molina – volume: 65 start-page: 1384 year: 2005 ident: BFonc2008481_CR19 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-3150 contributor: fullname: TT Junttila – volume: 275 start-page: 8641 year: 2000 ident: BFonc2008481_CR21 publication-title: J Biol Chem doi: 10.1074/jbc.275.12.8641 contributor: fullname: V Kainulainen – volume: 421 start-page: 756 year: 2003 ident: BFonc2008481_CR6 publication-title: Nature doi: 10.1038/nature01392 contributor: fullname: HS Cho – volume: 294 start-page: 2179 year: 2001 ident: BFonc2008481_CR29 publication-title: Science doi: 10.1126/science.1065412 contributor: fullname: CY Ni – volume: 277 start-page: 6318 year: 2002 ident: BFonc2008481_CR25 publication-title: J Biol Chem doi: 10.1074/jbc.M110371200 contributor: fullname: HJ Lee – volume: 17 start-page: 67 year: 2006 ident: BFonc2008481_CR26 publication-title: Mol Biol Cell doi: 10.1091/mbc.e05-05-0402 contributor: fullname: JA Määttä – volume: 26 start-page: 6905 year: 2007 ident: BFonc2008481_CR43 publication-title: Oncogene doi: 10.1038/sj.onc.1210501 contributor: fullname: M Sundvall – volume: 278 start-page: 33334 year: 2003 ident: BFonc2008481_CR24 publication-title: J Biol Chem doi: 10.1074/jbc.M305597200 contributor: fullname: A Komuro – volume: 14 start-page: 589 year: 2004 ident: BFonc2008481_CR13 publication-title: Oncol Res doi: 10.3727/0965040042707907 contributor: fullname: JL Gilmore – volume: 3 start-page: 740 year: 2002 ident: BFonc2008481_CR22 publication-title: Traffic doi: 10.1034/j.1600-0854.2002.31006.x contributor: fullname: M Katz – volume: 161 start-page: 1133 year: 2003 ident: BFonc2008481_CR2 publication-title: J Cell Biol doi: 10.1083/jcb.200212085 contributor: fullname: J Bao – volume: 90 start-page: 1746 year: 1993 ident: BFonc2008481_CR33 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.90.5.1746 contributor: fullname: GD Plowman – volume: 5 start-page: 2877 year: 1999 ident: BFonc2008481_CR38 publication-title: Clin Cancer Res contributor: fullname: R Srinivasan – volume: 13 start-page: 259 year: 2008 ident: BFonc2008481_CR41 publication-title: J Mammary Gland Biol Neoplasia doi: 10.1007/s10911-008-9079-3 contributor: fullname: M Sundvall – volume: 313 start-page: 2896 year: 2007 ident: BFonc2008481_CR17 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2007.03.042 contributor: fullname: E Iivanainen – volume: 3 start-page: 547 year: 1990 ident: BFonc2008481_CR32 publication-title: Protein Eng doi: 10.1093/protein/3.6.547 contributor: fullname: LR Paborsky – volume: 5 start-page: 341 year: 2005 ident: BFonc2008481_CR16 publication-title: Nat Rev Cancer doi: 10.1038/nrc1609 contributor: fullname: NE Hynes – volume: 58 start-page: 1773 year: 1998 ident: BFonc2008481_CR10 publication-title: Cancer Res contributor: fullname: C Furger – volume: 14 start-page: 1882 year: 2003 ident: BFonc2008481_CR14 publication-title: Mol Biol Cell doi: 10.1091/mbc.e02-10-0639 contributor: fullname: AQ Gomes – volume: 2 start-page: 127 year: 2002 ident: BFonc2008481_CR1 publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00097-1 contributor: fullname: DB Agus – volume: 83 start-page: 3825 year: 1986 ident: BFonc2008481_CR40 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.11.3825 contributor: fullname: H Sunada – volume: 455 start-page: 1069 year: 2008 ident: BFonc2008481_CR7 publication-title: Nature doi: 10.1038/nature07423 contributor: fullname: L Ding – volume: 10 start-page: 304 year: 2000 ident: BFonc2008481_CR20 publication-title: Trends Cardiovasc Med doi: 10.1016/S1050-1738(01)00065-2 contributor: fullname: TT Junttila – volume: 275 start-page: 10379 year: 2000 ident: BFonc2008481_CR35 publication-title: J Biol Chem doi: 10.1074/jbc.275.14.10379 contributor: fullname: C Rio – volume: 19 start-page: 6550 year: 2000 ident: BFonc2008481_CR27 publication-title: Oncogene doi: 10.1038/sj.onc.1204082 contributor: fullname: J Mendelsohn – volume: 185 start-page: 236 year: 1998 ident: BFonc2008481_CR39 publication-title: J Pathol doi: 10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7 contributor: fullname: R Srinivasan – volume: 57 start-page: 3272 year: 1997 ident: BFonc2008481_CR12 publication-title: Cancer Res contributor: fullname: RJ Gilbertson – volume: 5 start-page: 317 year: 2004 ident: BFonc2008481_CR9 publication-title: Cancer Cell doi: 10.1016/S1535-6108(04)00083-2 contributor: fullname: MC Franklin – volume: 271 start-page: 3884 year: 1996 ident: BFonc2008481_CR46 publication-title: J Biol Chem doi: 10.1074/jbc.271.7.3884 contributor: fullname: K Zhang – volume: 60 start-page: 3384 year: 2000 ident: BFonc2008481_CR23 publication-title: Cancer Res contributor: fullname: LN Klapper – volume: 22 start-page: 1114 year: 2003 ident: BFonc2008481_CR3 publication-title: EMBO J doi: 10.1093/emboj/cdg111 contributor: fullname: M Borrell-Pages – volume: 8 start-page: 3054 year: 2002 ident: BFonc2008481_CR11 publication-title: Clin Cancer Res contributor: fullname: RJ Gilbertson – volume: 21 start-page: 2849 year: 2007 ident: BFonc2008481_CR30 publication-title: FASEB J doi: 10.1096/fj.06-7925com contributor: fullname: J Omerovic – volume: 278 start-page: 38421 year: 2003 ident: BFonc2008481_CR5 publication-title: J Biol Chem doi: 10.1074/jbc.M302111200 contributor: fullname: QC Cheng – volume: 200 start-page: 290 year: 2003 ident: BFonc2008481_CR45 publication-title: J Pathol doi: 10.1002/path.1370 contributor: fullname: CJ Witton – volume: 1 start-page: 118 year: 2001 ident: BFonc2008481_CR4 publication-title: Nat Rev Cancer doi: 10.1038/35101072 contributor: fullname: P Carter – volume: 272 start-page: 26761 year: 1997 ident: BFonc2008481_CR8 publication-title: J Biol Chem doi: 10.1074/jbc.272.42.26761 contributor: fullname: K Elenius – volume: 2 start-page: 27 year: 2008 ident: BFonc2008481_CR31 publication-title: Recent Pat DNA Gene Seq doi: 10.2174/187221508783406602 contributor: fullname: I Paatero – volume: 4 start-page: 2957 year: 1998 ident: BFonc2008481_CR34 publication-title: Clin Cancer Res contributor: fullname: M Prewett – volume: 127 start-page: 45 year: 2006 ident: BFonc2008481_CR36 publication-title: Cell doi: 10.1016/j.cell.2006.09.013 contributor: fullname: J Schlessinger – volume: 271 start-page: 18989 year: 1996 ident: BFonc2008481_CR44 publication-title: J Biol Chem doi: 10.1074/jbc.271.31.18989 contributor: fullname: M Vecchi |
SSID | ssj0007902 |
Score | 2.2152233 |
Snippet | ErbB4 isoforms mediate different cellular activities depending on their susceptibility to proteolytic cleavage. The biological significance of ErbB4 cleavage... |
SourceID | proquest gale crossref pubmed pascalfrancis springer nature |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1309 |
SubjectTerms | Animals Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Care and treatment Cell Biology Cell growth Cell physiology Cell proliferation Cell Proliferation - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Child, Preschool ErbB-2 protein Female Fundamental and applied biological sciences. Psychology Genetics Gynecology. Andrology. Obstetrics Health aspects Histology Human Genetics Humans Internal Medicine Isoforms Male Mammary gland diseases Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Molecular and cellular biology Monoclonal antibodies Oncogenes Oncology original-article Phosphorylation Physiological aspects Protein Isoforms Proteolysis Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-4 Statistical analysis Trastuzumab Tumor cell lines Tumorigenesis Tumors Tyrosine Ubiquitination |
Title | Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms |
URI | http://dx.doi.org/10.1038/onc.2008.481 https://link.springer.com/article/10.1038/onc.2008.481 https://www.ncbi.nlm.nih.gov/pubmed/19151766 https://www.proquest.com/docview/227361666 https://www.proquest.com/docview/2641387458 https://search.proquest.com/docview/20438979 https://search.proquest.com/docview/67021593 |
Volume | 28 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEB6ahD6glHb7cpNudejjZGLLliWfSrJsCIWEUlLYm5FlOQ0Ue7t2CvvvO7OSHZZue_HBEow9I42-8YznA3iPp0gVSYPRicJwNTWlDkthorCUMjd1Wslk03j-4jI7_55-WYiFr83pfFnl4BM3jrpqDX0jP-Z4zmaU4_q8_BUSaRQlVz2Dxh4c8DilLO3B6fzy67fRFUtXdIgwIgoRyXBf-R4l6rhtjKukTFW8dSZ5zzw21ny81B2qq3Y8F7uA6F9J1M3ZdPYUnnhQyU7cKngG92wzgfuOZnI9gYezgdVtAg8ufDL9OVTE6OnKYBvW1qyk-vSeGVoHK0Zf9Nk1Bun9D1aumWaogdb8JODO0Bo3ZVutmasjx2diKFf_pt-w2HxVnqbspmsJDncv4OpsfjU7Dz3pQmhEIvpQUgP4pOZ1JSqdVLkUua1sHQldI1TBHa9VZCL08LU0PMsVwsGoirUo49hIUSYvYb9pG_samODaIhzBexZjPMtVbZUwsTKxValRSQAfBq0XS9dao9ikxBNVoHUcQSZaJ4BPZJKCdly_0kb7HwdQCvWuKk7QiSAK4REP4GhrJqrWbA0HzqijOBTDHaNAANMtO49T8GjHkDDNAzgcDF_4bd4V46JEyTtGM0QIRCegAng3DtNDUWFbY9tbnEOZ2Fzm_56RSYJlOarrlVtud8rKEa5JEv5xWH93wndp8s1_3-EQHnFPjhHFR7Dfr27tW0RcfTmFPbmQeFWzeOr32B9LPSlW |
link.rule.ids | 315,786,790,12083,12250,21416,27955,27956,31752,31753,33299,33300,33777,33778,43343,43612,43838,74100,74369,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BERQJIVgohJbWBx6nqHk5dk6orFot0O1pkXqLHNuBSijZblKk_ffMxElWKxausaVJZsaebzJjfwDvMIqYQGjMTiSmq4kulF9wHfiFEJkuEyPi7uL5-VU6-558vebXfW9O07dVDntit1GbWtM_8tMI42xKNa5Py1ufSKOouNozaNyHBwkOEoGBnG46PIRrOUQQEfiIY6K-7z2I5WldaddHmchwKyL1-_J4reaTpWpQWaVjudgFQ_8qoXaR6eIZPO0hJTtzPvAc7tlqAg8dyeR6AvvTgdNtAo_mfSn9BRji83RNsBWrS1ZQd3rLNHnBitH_fPYDU_T2JyvWTDH8_lr_ItjO0BY3RW3WzHWR4zsxlKt-0yEsdr4qPifspqkJDDcvYXFxvpjO_J5ywdc85q0v6Pr3uIxKw42KTSZ4Zo0tA65KBCq43pUMdID7eyl0lGYSwWBgQsWLMNSCF_EB7FV1ZV8D45GyCEbwmcUMz0aytJLrUOrQykTL2IP3g9bzpbtYI-8K4rHM0TqOHhOt48FHMklO661dKa36YwMohW6uys9wC0EMEgWRB0dbM1G1emvYc0YdxaGYyPEJeHC8ZedxCgZ2TAiTzIPDwfB5v8ibfHRJlLxjNEV8QGQC0oOTcZheitraKlvf4Ryqw2Yi-_eMVBAoy1Bdr5y7bZSVIVgTJPzD4H8b4bs0-ea_33AC-7PF_DK__HL17RAeu6JZ7IfREey1qzv7FrFXWxx3K-wPGKUo9g |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BEQUJIVhKCS2tDzxO0ebl2DmhsnRVHq04FKm3yHEcqFQlyyZF2n_PTOxktWLhGluaZJ6fM-MZgNcYRcpAaDydSDyuJrpQfsF14BdCZLpKShH3jefPL9Kz78nnK37lWgq1rqxy8Im9oy4bTf_IpxHG2ZRyXNPKVUV8-zh_v_jl0wApSrS6aRp34R4GxZQUXM7W1R7Clh8ioAh8xDSRq4EPYjltam1rKhMZbkQn56PHFpuPFqpFxlV24sU2SPpXOrWPUvMn8NjBS3Zi9eEp3DH1BO7bgZOrCTyYDfPdJrB77tLqz6Ck2Z62ILZmTcUKqlTvmCaNWDL6t89-4HG9-8mKFVMMv7_RNwThGcrlumjKFbMV5fhODOmq33Qhi50uiw8Ju24bAsbtHlzOTy9nZ74bv-BrHvPOF9QKPq6iquSlistM8MyUpgq4qhC0oO0rGegAfX0ldJRmEoFhUIaKF2GoBS_i57BTN7V5AYxHyiAwwWcGT3smkpWRXIdSh0YmWsYevBm4ni9sk428T47HMkfp2FGZKB0P3pFIcrK9bqm0clcIkAp1scpP0J0gHomCyIPDjZ3IWr2x7FmhjuSQTGRnC3hwtCHncQsGeTwcJpkHB4Pgc2fwbT6qJ1LespoiVqDBAtKD43GZXopK3GrT3OIeyslmIvv3jlQQQMuQXftW3dbMyhC4CSL-dtC_NfFtnHz53284hl00rvzrp4svB_DQ5s9iP4wOYadb3ppXCMO64qg3sD9xyC00 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Suppression+of+breast+cancer+cell+growth+by+a+monoclonal+antibody+targeting+cleavable+ErbB4+isoforms&rft.jtitle=Oncogene&rft.au=Hollm%C3%A9n%2C+M&rft.au=M%C3%A4%C3%A4tt%C3%A4%2C+J+A&rft.au=Bald%2C+L&rft.au=Sliwkowski%2C+M+X&rft.date=2009-03-12&rft.eissn=1476-5594&rft.volume=28&rft.issue=10&rft.spage=1309&rft.epage=1319&rft_id=info:doi/10.1038%2Fonc.2008.481&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon |