Leucine supplementation accelerates connective tissue repair of injured tibialis anterior muscle

• Published in: Nutrients Vol. 6; no. 10; pp. 3981 - 4001
• Main Authors: Pereira, Marcelo G, Silva, Meiricris T, Carlassara, Eduardo O C, Gonçalves, Dawit A, Abrahamsohn, Paulo A, Kettelhut, Isis C, Moriscot, Anselmo S, Aoki, Marcelo S, Miyabara, Elen H
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.09.2014; MDPI
• Subjects: Angiogenesis; Animals; Collagen - drug effects; Connective tissue; Connective Tissue - drug effects; Connective Tissue - metabolism; Connective Tissue - pathology; Dietary Supplements; Electronic mail systems; Growth factors; Kinases; Leucine - administration & dosage; Leucine - pharmacology; leucine supplementation; Male; Morphology; Muscle, Skeletal - injuries; Muscle, Skeletal - metabolism; Musculoskeletal system; Myofibrils - drug effects; Myosin Heavy Chains - drug effects; Protein synthesis; Protein-Serine-Threonine Kinases - metabolism; Proteins; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta - metabolism; Regeneration - drug effects; repair; skeletal muscle injury; Smad2 Protein - metabolism; Smad2/3; Smad3 Protein - metabolism; Spasm - diet therapy; Tibia; transforming growth factor-β receptor type I; Brazil

This study investigated the effect of leucine supplementation on the skeletal muscle regenerative process, focusing on the remodeling of connective tissue of the fast twitch muscle tibialis anterior (TA). Young male Wistar rats were supplemented with leucine (1.35 g/kg per day); then, TA muscles fro...