The impact of hypoxia and its modification of the outcome of radiotherapy

• Published in: Journal of radiation research Vol. 57; no. S1; pp. i90 - i98
• Main Authors: Horsman, Michael R., Overgaard, Jens
• Format: Journal Article
• Language: English
• Published: England The Japanese Radiation Research Society 01.08.2016; Oxford University Press
• Subjects: Animals; Heterogeneity; Humans; Hypoxia; Hypoxia - pathology; Imaging techniques; Linear energy transfer (LET); Neoplasms - pathology; Neoplasms - radiotherapy; Oxygenation; Radiation; Radiation dosage; Radiation therapy; Radiation tolerance; Randomized Controlled Trials as Topic; Review for Supplement – ICRR highlights; Treatment Outcome; Tumors; hypoxia; oxygen modifiers; vascular targeting agents; hypoxic cell cytotoxins; radiation; radiosensitizers

Since the initial observations made at the beginning of the last century, it has been established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can survive in these hypoxic conditions and are a major factor in tumor radioresistance. This significance has resulted in hyp...