Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway

• Published in: Gut microbes Vol. 15; no. 1; p. 2197836
• Main Authors: Zhang, Jian-Wei, Zhang, Dan, Yin, Hai-Sen, Zhang, Han, Hong, Kun-Qiao, Yuan, Jing-Ping, Yu, Bao-Ping
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2023; Taylor & Francis Group
• Subjects: Antineoplastic Agents - pharmacology; Cellular Senescence; chemoresistance; Culture Media, Conditioned - pharmacology; DNA Damage; Drug Resistance, Neoplasm - genetics; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - genetics; esophageal squamous cell carcinoma; Esophageal Squamous Cell Carcinoma - drug therapy; Esophageal Squamous Cell Carcinoma - genetics; Fusobacterium nucleatum; Gastrointestinal Microbiome; Humans; In Situ Hybridization, Fluorescence; Neoplasm Recurrence, Local; Research Paper; RNA, Ribosomal, 16S; Senescence-Associated Secretory Phenotype; esophageal squamous cell carcinoma; chemoresistance; cellular senescence; senescence-associated secretory phenotype; Fusobacterium nucleatum

Senescence frequently occurs in cancer cells in response to chemotherapy (called therapy-induced senescence). Senescent cells can exert paracrine effects through the senescence-associated secretory phenotype (SASP) promoting cancer recurrence and chemoresistance. The altered gut microbiota has been...