Sphingolipid biosynthesis in man and microbes

• Published in: Natural product reports Vol. 35; no. 9; pp. 921 - 954
• Main Authors: Harrison, Peter J, Dunn, Teresa M, Campopiano, Dominic J
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 19.09.2018
• Subjects: Alcohol Oxidoreductases - genetics; Alcohol Oxidoreductases - metabolism; Aldehyde-Lyases - chemistry; Aldehyde-Lyases - genetics; Aldehyde-Lyases - metabolism; Animals; Asthma; Biosynthesis; Cell membranes; Chemistry; Diabetes mellitus; Drug delivery systems; Enzymes; Fungal Proteins - genetics; Fungal Proteins - metabolism; Humans; Lipid metabolism; Lipids; Membranes; Metabolism; Microorganisms; Mutation; Natural products; Organic chemistry; Phosphotransferases (Alcohol Group Acceptor) - chemistry; Phosphotransferases (Alcohol Group Acceptor) - genetics; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Proteins; Second messengers; Serine C-Palmitoyltransferase - genetics; Serine C-Palmitoyltransferase - metabolism; Signal transduction; Sphingolipids; Sphingolipids - biosynthesis

A new review covering up to 2018 Sphingolipids are essential molecules that, despite their long history, are still stimulating interest today. The reasons for this are that, as well as playing structural roles within cell membranes, they have also been shown to perform a myriad of cell signalling fu...