Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants

In Vitro Activity of Antibodies and Drugs against OmicronIn this study, investigators who were evaluating in vitro neutralization of omicron subvariants by monoclonal antibodies and antiviral drugs found considerable variation among the agents.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 387; no. 5; pp. 468 - 470
Main Authors Takashita, Emi, Yamayoshi, Seiya, Simon, Viviana, van Bakel, Harm, Sordillo, Emilia M., Pekosz, Andrew, Fukushi, Shuetsu, Suzuki, Tadaki, Maeda, Ken, Halfmann, Peter, Sakai-Tagawa, Yuko, Ito, Mutsumi, Watanabe, Shinji, Imai, Masaki, Hasegawa, Hideki, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 04.08.2022
Subjects
Antibodies, Monoclonal - therapeutic use
Antibodies, Neutralizing - therapeutic use
Antibodies, Viral - immunology
Antiviral agents
Antiviral Agents - therapeutic use
Coronavirus
Coronaviruses
Correspondence
COVID-19
COVID-19 - immunology
COVID-19 Drug Treatment
Disease transmission
Drugs
FDA approval
Humans
Immunologic Factors - therapeutic use
Infectious Disease
Infectious diseases
Influenza
Monoclonal antibodies
Mutation
Pathogenesis
Proteins
R&D
Research & development
RNA polymerase
SARS-CoV-2 - drug effects
Severe acute respiratory syndrome coronavirus 2
Vaccine Efficacy
Viral Infections
United States > US
Japan
Online AccessGet full text

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Abstract In Vitro Activity of Antibodies and Drugs against OmicronIn this study, investigators who were evaluating in vitro neutralization of omicron subvariants by monoclonal antibodies and antiviral drugs found considerable variation among the agents.
AbstractList In Vitro Activity of Antibodies and Drugs against OmicronIn this study, investigators who were evaluating in vitro neutralization of omicron subvariants by monoclonal antibodies and antiviral drugs found considerable variation among the agents.
In this study, investigators who were evaluating in vitro neutralization of omicron subvariants by monoclonal antibodies and antiviral drugs found considerable variation among the agents.
Author Takashita, Emi
Suzuki, Tadaki
Watanabe, Shinji
Pekosz, Andrew
Yamayoshi, Seiya
Sordillo, Emilia M.
Kawaoka, Yoshihiro
Sakai-Tagawa, Yuko
Fukushi, Shuetsu
van Bakel, Harm
Imai, Masaki
Simon, Viviana
Ito, Mutsumi
Hasegawa, Hideki
Maeda, Ken
Halfmann, Peter
Author_xml – sequence: 1
  givenname: Emi
  orcidid: 0000-0002-9064-4699
  surname: Takashita
  fullname: Takashita, Emi
  organization: National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 2
  givenname: Seiya
  orcidid: 0000-0001-7768-5157
  surname: Yamayoshi
  fullname: Yamayoshi, Seiya
  organization: University of Tokyo, Tokyo, Japan
– sequence: 3
  givenname: Viviana
  surname: Simon
  fullname: Simon, Viviana
  organization: Icahn School of Medicine at Mount Sinai, New York, NY
– sequence: 4
  givenname: Harm
  orcidid: 0000-0002-1376-6916
  surname: van Bakel
  fullname: van Bakel, Harm
  organization: Icahn School of Medicine at Mount Sinai, New York, NY
– sequence: 5
  givenname: Emilia M.
  surname: Sordillo
  fullname: Sordillo, Emilia M.
  organization: Icahn School of Medicine at Mount Sinai, New York, NY
– sequence: 6
  givenname: Andrew
  orcidid: 0000-0003-3248-1761
  surname: Pekosz
  fullname: Pekosz, Andrew
  organization: Johns Hopkins University, Baltimore, MD
– sequence: 7
  givenname: Shuetsu
  surname: Fukushi
  fullname: Fukushi, Shuetsu
  organization: National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 8
  givenname: Tadaki
  orcidid: 0000-0002-3820-9542
  surname: Suzuki
  fullname: Suzuki, Tadaki
  organization: National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 9
  givenname: Ken
  surname: Maeda
  fullname: Maeda, Ken
  organization: National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 10
  givenname: Peter
  surname: Halfmann
  fullname: Halfmann, Peter
  organization: University of Wisconsin–Madison, Madison, WI
– sequence: 11
  givenname: Yuko
  surname: Sakai-Tagawa
  fullname: Sakai-Tagawa, Yuko
  organization: University of Tokyo, Tokyo, Japan
– sequence: 12
  givenname: Mutsumi
  surname: Ito
  fullname: Ito, Mutsumi
  organization: University of Tokyo, Tokyo, Japan
– sequence: 13
  givenname: Shinji
  surname: Watanabe
  fullname: Watanabe, Shinji
  organization: National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 14
  givenname: Masaki
  surname: Imai
  fullname: Imai, Masaki
  organization: University of Tokyo, Tokyo, Japan
– sequence: 15
  givenname: Hideki
  surname: Hasegawa
  fullname: Hasegawa, Hideki
  organization: National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 16
  givenname: Yoshihiro
  surname: Kawaoka
  fullname: Kawaoka, Yoshihiro
  email: yoshihiro.kawaoka@wisc.edu
  organization: University of Tokyo, Tokyo, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35857646$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/s41591-022-01792-5
10.1056/NEJMc2201933
10.1038/s41586-022-04594-4
ContentType Journal Article
Copyright Copyright © 2022 Massachusetts Medical Society. All rights reserved.
Copyright © 2022 Massachusetts Medical Society. All rights reserved. 2022 Massachusetts Medical Society
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This article is made available via the PMC Open Access Subset for unrestricted re-use, except commercial resale, and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the Covid-19 pandemic or until revoked in writing. Upon expiration of these permissions, PMC is granted a license to make this article available via PMC and Europe PMC, subject to existing copyright protections.
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Drs. Takashita and Yamayoshi contributed equally to this letter.
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References (r2) 2022
Bruel, T, Hadjadj, J, Maes, P (r3) 2022; 28
(r1) 2022
Iketani, S, Liu, L, Guo, Y (r4) 2022; 604
Takashita, E, Kinoshita, N, Yamayoshi, S (r5) 2022; 386
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  ident: r2
  article-title: Overview of variants/mutations ;(https://covariants.org/per-variant)
– year: 2022
  ident: r1
  article-title: Weekly epidemiological update on COVID-19 ;(https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---1-june-2022)
– volume: 28
  start-page: 1297
  year: 2022
  end-page: 1302
  ident: r3
  article-title: Serum neutralization of SARS-CoV-2 omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies.
  publication-title: Nat Med
– volume: 604
  start-page: 553
  year: 2022
  end-page: 556
  ident: r4
  article-title: Antibody evasion properties of SARS-CoV-2 omicron sublineages.
  publication-title: Nature
– volume: 386
  start-page: 1475
  year: 2022
  end-page: 1477
  ident: r5
  article-title: Efficacy of antiviral agents against the SARS-CoV-2 omicron subvariant BA.2.
  publication-title: N Engl J Med
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  doi: 10.1038/s41591-022-01792-5
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  doi: 10.1056/NEJMc2201933
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  doi: 10.1038/s41586-022-04594-4
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Snippet In this study, investigators who were evaluating in vitro neutralization of omicron subvariants by monoclonal antibodies and antiviral drugs found considerable...
In Vitro Activity of Antibodies and Drugs against OmicronIn this study, investigators who were evaluating in vitro neutralization of omicron subvariants by...
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SubjectTerms Antibodies, Monoclonal - therapeutic use
Antibodies, Neutralizing - therapeutic use
Antibodies, Viral - immunology
Antiviral agents
Antiviral Agents - therapeutic use
Coronavirus
Coronaviruses
Correspondence
COVID-19
COVID-19 - immunology
COVID-19 Drug Treatment
Disease transmission
Drugs
FDA approval
Humans
Immunologic Factors - therapeutic use
Infectious Disease
Infectious diseases
Influenza
Monoclonal antibodies
Mutation
Pathogenesis
Proteins
R&D
Research & development
RNA polymerase
SARS-CoV-2 - drug effects
Severe acute respiratory syndrome coronavirus 2
Vaccine Efficacy
Viral Infections
SubjectTermsDisplay Coronavirus
Infectious Disease
Viral Infections
Title Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants
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