Paracrine effects of mir-210-3p on angiogenesis in hypoxia-treated c-kit-positive cardiac cells

• Published in: Annals of medicine (Helsinki) Vol. 55; no. 2; p. 2237690
• Main Authors: Shen, Louyi, Fan, Guan, Yang, Guoliang, Yang, Zhijie, Gui, Chun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 12.12.2023; Taylor & Francis Group
• Subjects: Animals; c-kit-positive cardiac cells; Cardiology & Cardiovascular Disorders; Culture Media, Conditioned - pharmacology; Endothelial Cells; Humans; hypoxia; Hypoxia - genetics; ischemic cardiomyopathy; Mice; MicroRNAs - genetics; miR-210-3p; Myocardial Ischemia - genetics; paracrine functions; Vascular Endothelial Growth Factor A - genetics; hypoxia; ischemic cardiomyopathy; miR-210-3p; c-kit-positive cardiac cells; paracrine functions

Objective: Treatment with c-kit-positive cardiac cells (CPCs) has been shown to improve the prognosis of ischemic heart disease. MicroRNAs (miRNAs) confer protection by enhancing the cardiac repair process, but their specific functional mechanisms remain unclear. This study aimed to screen for diffe...