Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB

Neither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and nirmatrelvir were efficacious against both in vitro.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 388; no. 1; pp. 89 - 91
Main Authors Imai, Masaki, Ito, Mutsumi, Kiso, Maki, Yamayoshi, Seiya, Uraki, Ryuta, Fukushi, Shuetsu, Watanabe, Shinji, Suzuki, Tadaki, Maeda, Ken, Sakai-Tagawa, Yuko, Iwatsuki-Horimoto, Kiyoko, Halfmann, Peter J., Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 05.01.2023
Subjects
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Coronavirus
Coronaviruses
Correspondence
COVID-19
COVID-19 - virology
COVID-19 Drug Treatment
Disease transmission
Drugs
FDA approval
Humans
Infectious Disease
Infectious diseases
Medical research
Monoclonal antibodies
R&D
Research & development
RNA polymerase
SARS-CoV-2 - drug effects
Severe acute respiratory syndrome coronavirus 2
Treatment Outcome
Viral Infections
Japan
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Abstract Neither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and nirmatrelvir were efficacious against both in vitro.
AbstractList Antiviral Agents and Omicron BQ.1.1 and XBBNeither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and nirmatrelvir were efficacious against both in vitro.
Neither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and nirmatrelvir were efficacious against both in vitro.
Author Uraki, Ryuta
Suzuki, Tadaki
Watanabe, Shinji
Iwatsuki-Horimoto, Kiyoko
Yamayoshi, Seiya
Halfmann, Peter J.
Kiso, Maki
Kawaoka, Yoshihiro
Sakai-Tagawa, Yuko
Fukushi, Shuetsu
Imai, Masaki
Ito, Mutsumi
Maeda, Ken
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  organization: University of Tokyo, Tokyo, Japan
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  fullname: Ito, Mutsumi
  organization: University of Tokyo, Tokyo, Japan
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  surname: Kiso
  fullname: Kiso, Maki
  organization: University of Tokyo, Tokyo, Japan
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  givenname: Seiya
  orcidid: 0000-0001-7768-5157
  surname: Yamayoshi
  fullname: Yamayoshi, Seiya
  organization: University of Tokyo, Tokyo, Japan
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  givenname: Ryuta
  surname: Uraki
  fullname: Uraki, Ryuta
  organization: University of Tokyo, Tokyo, Japan
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  surname: Fukushi
  fullname: Fukushi, Shuetsu
  organization: National Institute of Infectious Diseases, Tokyo, Japan
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  surname: Watanabe
  fullname: Watanabe, Shinji
  organization: National Institute of Infectious Diseases, Tokyo, Japan
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  surname: Suzuki
  fullname: Suzuki, Tadaki
  organization: National Institute of Infectious Diseases, Tokyo, Japan
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  surname: Maeda
  fullname: Maeda, Ken
  organization: National Institute of Infectious Diseases, Tokyo, Japan
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  givenname: Yuko
  surname: Sakai-Tagawa
  fullname: Sakai-Tagawa, Yuko
  organization: University of Tokyo, Tokyo, Japan
– sequence: 11
  givenname: Kiyoko
  surname: Iwatsuki-Horimoto
  fullname: Iwatsuki-Horimoto, Kiyoko
  organization: University of Tokyo, Tokyo, Japan
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  givenname: Peter J.
  surname: Halfmann
  fullname: Halfmann, Peter J.
  organization: University of Wisconsin–Madison, Madison, WI
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  givenname: Yoshihiro
  surname: Kawaoka
  fullname: Kawaoka, Yoshihiro
  email: yoshihiro.kawaoka@wisc.edu
  organization: University of Tokyo, Tokyo, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36476720$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1056/NEJMc2201933
10.1038/s41586-022-04594-4
10.1038/s41586-022-04980-y
10.1056/NEJMc2207519
10.1038/s41586-022-05053-w
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This article is made available via the PMC Open Access Subset for unrestricted re-use, except commercial resale, and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the Covid-19 pandemic or until revoked in writing. Upon expiration of these permissions, PMC is granted a license to make this article available via PMC and Europe PMC, subject to existing copyright protections.
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content type line 14
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Drs. Imai and Ito and Drs. Kiso and Yamayoshi contributed equally to this letter.
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References Takashita, E, Yamayoshi, S, Simon, V (r4) 2022; 387
Takashita, E, Kinoshita, N, Yamayoshi, S (r2) 2022; 386
Cao, Y, Yisimayi, A, Jian, F (r3) 2022; 608
Wang, Q, Guo, Y, Iketani, S (r5) 2022; 608
Iketani, S, Liu, L, Guo, Y (r1) 2022; 604
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References_xml – volume: 608
  start-page: 593
  year: 2022
  end-page: 602
  ident: r3
  article-title: BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by omicron infection.
  publication-title: Nature
– volume: 387
  start-page: 468
  year: 2022
  end-page: 470
  ident: r4
  article-title: Efficacy of antibodies and antiviral drugs against omicron BA.2.12.1, BA.4, and BA.5 subvariants.
  publication-title: N Engl J Med
– volume: 386
  start-page: 1475
  year: 2022
  end-page: 1477
  ident: r2
  article-title: Efficacy of antiviral agents against the SARS-CoV-2 omicron subvariant BA.2.
  publication-title: N Engl J Med
– volume: 608
  start-page: 603
  year: 2022
  end-page: 608
  ident: r5
  article-title: Antibody evasion by SARS-CoV-2 omicron subvariants BA.2.12.1, BA.4 and BA.5.
  publication-title: Nature
– volume: 604
  start-page: 553
  year: 2022
  end-page: 556
  ident: r1
  article-title: Antibody evasion properties of SARS-CoV-2 omicron sublineages.
  publication-title: Nature
– ident: e_1_3_4_3_2
  doi: 10.1056/NEJMc2201933
– ident: e_1_3_4_2_2
  doi: 10.1038/s41586-022-04594-4
– ident: e_1_3_4_4_2
  doi: 10.1038/s41586-022-04980-y
– ident: e_1_3_4_5_2
  doi: 10.1056/NEJMc2207519
– ident: e_1_3_4_6_2
  doi: 10.1038/s41586-022-05053-w
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Snippet Neither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and...
Antiviral Agents and Omicron BQ.1.1 and XBBNeither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB,...
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SubjectTerms Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Coronavirus
Coronaviruses
Correspondence
COVID-19
COVID-19 - virology
COVID-19 Drug Treatment
Disease transmission
Drugs
FDA approval
Humans
Infectious Disease
Infectious diseases
Medical research
Monoclonal antibodies
R&D
Research & development
RNA polymerase
SARS-CoV-2 - drug effects
Severe acute respiratory syndrome coronavirus 2
Treatment Outcome
Viral Infections
SubjectTermsDisplay Coronavirus
Infectious Disease
Viral Infections
Title Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB
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