Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma
HEREDITARY mutations of tumor-suppressor genes have been correlated with a genetic predisposition to cancer, and several such genes have been linked to distinct familial cancer syndromes. 1 The best-studied example is retinoblastoma; about 40 percent of the cases are due to germline mutations of the...
Saved in:
| Published in | The New England journal of medicine Vol. 326; no. 20; pp. 1301 - 1308 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Boston, MA
Massachusetts Medical Society
14.05.1992
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | HEREDITARY mutations of tumor-suppressor genes have been correlated with a genetic predisposition to cancer, and several such genes have been linked to distinct familial cancer syndromes.
1
The best-studied example is retinoblastoma; about 40 percent of the cases are due to germline mutations of the retinoblastoma gene (the remaining 60 percent of cases are nonhereditary and are due to somatic mutations).
2
Patients with the hereditary form have a high risk of multifocal retinoblastoma and other tumors, and they may pass the disease to their progeny as an autosomal dominant trait. Three fourths of the hereditary cases of retinoblastoma occur in patients . . . |
|---|---|
| AbstractList | BACKGROUNDRecent studies have identified germline mutations of the p53 tumor-suppressor gene in families with the Li-Fraumeni syndrome, a rare inherited disorder characterized by a high risk of sarcomas of bone and soft tissue, breast cancer, and other tumors. In this report, we address the possibility that some sporadic sarcomas may be associated with new germline mutations of the p53 gene, which would not be manifested as familial cancer unless the patient survived to reproduce.METHODSWe studied DNA from peripheral leukocytes of 196 patients with sarcoma and from 200 controls. Of the 196 patients with sarcoma, 15 were selected because they had had multiple primary cancers or had a family history of cancer. The entire coding sequence and splice junctions of the p53 gene were analyzed for mutations.RESULTSEight germline mutations were found, three in patients with no known family history of cancer and five in patients with an unusual personal or family history of cancer. Four mutations caused amino acid substitutions, and four caused stop codons. These mutations were not present in any of the 200 controls.CONCLUSIONSNew germline mutations of the p53 gene are rare among patients with "sporadic" sarcoma but may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer. Diverse mutations of this gene were associated with an increased likelihood of cancer; hence, the entire gene should be considered a target for heritable mutation. It appears that the group of patients with cancer who carry germline mutations of the p53 gene is more diverse than is suggested by the clinical definition of the Li-Fraumeni syndrome. The identification of carriers could be of substantial clinical importance. Abstract Background Recent studies have identified germline mutations of the p53 tumor-suppressor gene in families with the Li--Fraumeni syndrome, a rare inherited disorder characterized by a high risk of sarcomas of bone and soft tissue, breast cancer, and other tumors. In this report, we address the possibility that some sporadic sarcomas may be associated with new germline mutations of the p53 gene, which would not be manifested as familial cancer unless the patient survived to reproduce. Methods We studied DNA from peripheral leukocytes of 196 patients with sarcoma and from 200 controls. Of the 196 patients with sarcoma, 15 were selected because they had had multiple primary cancers or had a family history of cancer. The entire coding sequence and splice junctions of the p53 gene were analyzed for mutations. Results Eight germline mutations were found, three in patients with no known family history of cancer and five in patients with an unusual personal or family history of cancer. Four mutations caused amino acid substitutions, and four caused stop codons. These mutations were not present in any of the 200 controls. Conclusions New germline mutations of the p53 gene are rare among patients with "sporadic" sarcoma but may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer. Diverse mutations of this gene were associated with an increased likelihood of cancer; hence, the entire gene should be considered a target for heritable mutation. It appears that the group of patients with cancer who carry germline mutations of the p53 gene is more diverse than is suggested by the clinical definition of the Li--Fraumeni syndrome. The identification of carriers could be of substantial clinical importance. (N Engl J Med 1992;326: 1301-8.) We studied DNA from peripheral leukocytes of 196 patients with sarcoma and from 200 controls. Of the 196 patients with sarcoma, 15 were selected because they had had multiple primary cancers or had a family history of cancer. The entire coding sequence and splice junctions of the p53 gene were analyzed for mutations. Eight germline mutations were found, three in patients with no known family history of cancer and five in patients with an unusual personal or family history of cancer. Four mutations caused amino acid substitutions, and four caused stop codons. These mutations were not present in any of the 200 controls. HEREDITARY mutations of tumor-suppressor genes have been correlated with a genetic predisposition to cancer, and several such genes have been linked to distinct familial cancer syndromes. 1 The best-studied example is retinoblastoma; about 40 percent of the cases are due to germline mutations of the retinoblastoma gene (the remaining 60 percent of cases are nonhereditary and are due to somatic mutations). 2 Patients with the hereditary form have a high risk of multifocal retinoblastoma and other tumors, and they may pass the disease to their progeny as an autosomal dominant trait. Three fourths of the hereditary cases of retinoblastoma occur in patients . . . Recent studies have identified germline mutations of the p53 tumor-suppressor gene in families with the Li-Fraumeni syndrome, a rare inherited disorder characterized by a high risk of sarcomas of bone and soft tissue, breast cancer, and other tumors. In this report, we address the possibility that some sporadic sarcomas may be associated with new germline mutations of the p53 gene, which would not be manifested as familial cancer unless the patient survived to reproduce. We studied DNA from peripheral leukocytes of 196 patients with sarcoma and from 200 controls. Of the 196 patients with sarcoma, 15 were selected because they had had multiple primary cancers or had a family history of cancer. The entire coding sequence and splice junctions of the p53 gene were analyzed for mutations. Eight germline mutations were found, three in patients with no known family history of cancer and five in patients with an unusual personal or family history of cancer. Four mutations caused amino acid substitutions, and four caused stop codons. These mutations were not present in any of the 200 controls. New germline mutations of the p53 gene are rare among patients with "sporadic" sarcoma but may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer. Diverse mutations of this gene were associated with an increased likelihood of cancer; hence, the entire gene should be considered a target for heritable mutation. It appears that the group of patients with cancer who carry germline mutations of the p53 gene is more diverse than is suggested by the clinical definition of the Li-Fraumeni syndrome. The identification of carriers could be of substantial clinical importance. |
| Author | Dayton, Siri H Weichselbaum, Ralph R Toguchida, Junya Herrera, Guillermo E Yamamuro, Takao Meyers, Paul A Beaughamp, Roberta L Little, John B Yandell, David W Sasaki, Masao S Ishizaki, Kanji Yamaguchi, Toshikazu |
| Author_xml | – sequence: 1 givenname: Junya surname: Toguchida fullname: Toguchida, Junya – sequence: 2 givenname: Toshikazu surname: Yamaguchi fullname: Yamaguchi, Toshikazu – sequence: 3 givenname: Siri H surname: Dayton fullname: Dayton, Siri H – sequence: 4 givenname: Roberta L surname: Beaughamp fullname: Beaughamp, Roberta L – sequence: 5 givenname: Guillermo E surname: Herrera fullname: Herrera, Guillermo E – sequence: 6 givenname: Kanji surname: Ishizaki fullname: Ishizaki, Kanji – sequence: 7 givenname: Takao surname: Yamamuro fullname: Yamamuro, Takao – sequence: 8 givenname: Paul A surname: Meyers fullname: Meyers, Paul A – sequence: 9 givenname: John B surname: Little fullname: Little, John B – sequence: 10 givenname: Masao S surname: Sasaki fullname: Sasaki, Masao S – sequence: 11 givenname: Ralph R surname: Weichselbaum fullname: Weichselbaum, Ralph R – sequence: 12 givenname: David W surname: Yandell fullname: Yandell, David W |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4353637$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/1565143$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkV9rFTEQxYNU6m31E4gQVHyR1SSTZJNHKW1VWi1UH3xacrOzdi-b7G2ya_Hbm-VeFMQ_eUhgzu_MTDhH5CCOEQl5zNkrzpR-_eH0_SW3VjDFJQgtGOP3yIorgEpKpg_IijFhKllbeECOct6wcri0h-SQK72YVuTLVcJvbsDokbrY0ust-inNgY4dPccUhj4ivZwnN_VjzEt1ukG6VVDUorgwxq_0qqgYp0zv-umGXrvkx-AekvudGzI-2r_H5PPZ6aeTt9XFx_N3J28uKq9ATRVgq7y0a0TeosFOScmtEaLVrGtr46xltfTIDFh02rWwFsJoA-WugWsOx-TFru82jbcz5qkJffY4DC7iOOemFsYKLeG_INe6VgZkAZ_-Bm7GOcXyiUYIsLI2qi7Qs79BZX-Q0hi5ULCjfBpzTtg129QHl743nDVLiM0fQiyuJ_ve8zpg-8uzS63oz_e6y94NXXLR9_knJkGBhmX4yx0WQm4ibsI_h_4AgbeuZQ |
| CODEN | NEJMAG |
| CitedBy_id | crossref_primary_10_1016_0304_419X_93_90004_V crossref_primary_10_1002_jso_23809 crossref_primary_10_1136_jmg_32_12_942 crossref_primary_10_3109_02713689409167295 crossref_primary_10_1111_cas_14919 crossref_primary_10_1097_MPH_0000000000002097 crossref_primary_10_1200_PO_20_00087 crossref_primary_10_1016_S0031_3955_02_00095_0 crossref_primary_10_1016_0749_2081_92_90033_Y crossref_primary_10_1158_1541_7786_MCR_18_0620 crossref_primary_10_1002_mpo_2950230407 crossref_primary_10_1038_labinvest_3780431 crossref_primary_10_1007_s10147_014_0729_8 crossref_primary_10_1016_0959_8049_94_00383_G crossref_primary_10_1038_ng1193_225 crossref_primary_10_1002_gcc_2870090203 crossref_primary_10_1016_0145_2126_93_90130_D crossref_primary_10_1023_A_1014403613747 crossref_primary_10_1016_j_ejca_2009_03_005 crossref_primary_10_1016_0959_8049_95_00121_X crossref_primary_10_1016_S0748_7983_98_93896_3 crossref_primary_10_1097_00130404_200507000_00005 crossref_primary_10_1002_ijc_21195 crossref_primary_10_1016_S0146_6435_98_00007_3 crossref_primary_10_1038_sj_onc_1204621 crossref_primary_10_1080_15513810009168647 crossref_primary_10_1634_theoncologist_9_4_422 crossref_primary_10_1016_0046_8177_94_90220_8 crossref_primary_10_1002_ijc_2910630312 crossref_primary_10_1016_S0009_8981_96_06442_X crossref_primary_10_1016_S0889_8588_18_30164_3 crossref_primary_10_1038_sj_bjc_6601748 crossref_primary_10_1002_ssu_2980100503 crossref_primary_10_1002_jso_21763 crossref_primary_10_1002__SICI_1098_1004_1997_9_2_157__AID_HUMU8_3_0_CO_2_6 crossref_primary_10_1016_S0022_5347_01_67517_7 crossref_primary_10_1002_sim_4780130206 crossref_primary_10_1097_00000372_199806000_00015 crossref_primary_10_1002_ijc_20269 crossref_primary_10_1016_S0165_4608_96_00072_6 crossref_primary_10_1016_j_jdcr_2017_11_011 crossref_primary_10_1016_S0165_1110_96_90010_X crossref_primary_10_1016_S1368_8375_01_00078_1 crossref_primary_10_1007_s00117_022_01071_x crossref_primary_10_1016_S0022_3476_98_70007_1 crossref_primary_10_1016_0959_8049_93_90023_9 crossref_primary_10_1007_BF02272849 crossref_primary_10_1016_0959_8049_96_00104_9 crossref_primary_10_1002_ijc_29882 crossref_primary_10_1016_S1053_4296_99_80025_3 crossref_primary_10_1111_j_1349_7006_1992_tb02730_x crossref_primary_10_1038_bjc_2014_263 crossref_primary_10_1016_0027_5107_93_90014_7 crossref_primary_10_1016_0165_4608_93_90166_J crossref_primary_10_1016_S0889_8588_18_30244_2 crossref_primary_10_1007_s11912_009_0061_z crossref_primary_10_1016_S0344_0338_96_80090_2 crossref_primary_10_1515_bchm3_1993_374_1_6_227 crossref_primary_10_1097_00003081_199803000_00024 crossref_primary_10_1158_1078_0432_CCR_07_0395 crossref_primary_10_1016_S0303_8467_98_00072_9 crossref_primary_10_1080_17453674_1997_11744704 crossref_primary_10_1002_jso_20720 crossref_primary_10_1016_0140_6736_92_92943_A crossref_primary_10_1093_jnci_89_22_1706 crossref_primary_10_3389_fonc_2015_00208 crossref_primary_10_1002_humu_1380020407 crossref_primary_10_1002__SICI_1097_0347_199709_19_6_513__AID_HED9_3_0_CO_2_1 crossref_primary_10_1002_hed_20820 crossref_primary_10_1016_j_bbcan_2021_188512 crossref_primary_10_3109_08880019509009482 crossref_primary_10_1016_S0344_0338_11_80599_6 crossref_primary_10_1056_NEJM199307013290105 crossref_primary_10_1002_pbc_24269 crossref_primary_10_1002_jor_1100170503 crossref_primary_10_1007_BF01213553 crossref_primary_10_3389_fonc_2020_554388 crossref_primary_10_1038_ng1093_124 crossref_primary_10_3390_cancers14143503 crossref_primary_10_1016_S0889_8588_18_30082_0 crossref_primary_10_1002_mpo_10060 crossref_primary_10_1111_j_1349_7006_2000_tb01028_x crossref_primary_10_1002_gcc_2870110309 crossref_primary_10_1002_humu_10185 crossref_primary_10_1002_stem_5530130741 crossref_primary_10_1007_s11626_999_0026_4 crossref_primary_10_1097_CORR_0000000000002745 crossref_primary_10_1158_1078_0432_CCR_16_0610 crossref_primary_10_1186_s12864_017_3895_z crossref_primary_10_1056_NEJM199205143262008 crossref_primary_10_1111_his_12280 crossref_primary_10_1158_0008_5472_CAN_22_0172 crossref_primary_10_1038_npjgenmed_2015_3 crossref_primary_10_1097_00043426_200305000_00003 crossref_primary_10_1101_mcs_a002246 crossref_primary_10_1111_j_1349_7006_1998_tb00637_x crossref_primary_10_1186_2045_3329_2_1 crossref_primary_10_1016_S0030_5898_20_32089_7 crossref_primary_10_1038_s41418_022_00980_7 crossref_primary_10_1002_ijc_2910640606 crossref_primary_10_1016_0165_4608_94_90467_7 crossref_primary_10_1002_mpo_2950250612 crossref_primary_10_1093_jnci_90_8_606 crossref_primary_10_1089_dna_1995_14_983 crossref_primary_10_1186_bcr2647 crossref_primary_10_1002_pbc_20700 crossref_primary_10_1136_jmg_35_12_1036 crossref_primary_10_1016_0165_4608_95_00367_3 crossref_primary_10_1016_j_critrevonc_2015_08_019 crossref_primary_10_1016_j_mporth_2016_08_004 crossref_primary_10_1016_0959_8049_93_90001_V crossref_primary_10_1136_mp_48_5_M221 crossref_primary_10_1016_j_mpsur_2020_06_018 crossref_primary_10_1086_374567 crossref_primary_10_1371_journal_pone_0135074 crossref_primary_10_1007_BF02316809 crossref_primary_10_1093_jnci_djv101 crossref_primary_10_3892_ol_2017_6767 crossref_primary_10_1016_j_canlet_2018_10_033 crossref_primary_10_1007_s12253_014_9836_0 crossref_primary_10_1007_BF02303500 crossref_primary_10_1016_S0344_0338_98_80096_4 crossref_primary_10_1056_NEJM199310283291807 crossref_primary_10_1002__SICI_1096_911X_1996_27_1__25__AID_MPO5_3_0_CO_2_P crossref_primary_10_1007_BF02990955 crossref_primary_10_1002_jso_2930560218 crossref_primary_10_1002_gepi_1370120103 crossref_primary_10_1007_s11999_008_0335_z crossref_primary_10_1002_pbc_24213 crossref_primary_10_1002_1097_0142_19930801_72_3_923__AID_CNCR2820720343_3_0_CO_2_Y crossref_primary_10_1002_ajmg_a_62767 crossref_primary_10_1016_S0272_2712_18_30292_0 crossref_primary_10_1002_cncr_26390 crossref_primary_10_1016_0165_4608_94_00213_U crossref_primary_10_1007_BF02710274 crossref_primary_10_1016_0304_3835_95_04048_X crossref_primary_10_1016_0165_4608_93_90233_C crossref_primary_10_5144_0256_4947_1995_252 crossref_primary_10_1002_ajh_2830450412 crossref_primary_10_1016_0304_3835_93_90187_E crossref_primary_10_1016_j_ajoms_2019_05_004 crossref_primary_10_1016_S0959_8049_97_00251_7 crossref_primary_10_1038_nrendo_2017_16 crossref_primary_10_6004_jnccn_2021_7034 crossref_primary_10_1016_S0305_7372_98_90001_9 crossref_primary_10_3390_ijms22137160 crossref_primary_10_1111_j_1600_0676_1993_tb00626_x crossref_primary_10_1016_0009_8981_95_06066_M crossref_primary_10_1093_carcin_bgq256 crossref_primary_10_3390_cells11223614 crossref_primary_10_1200_JCO_2005_10_042 crossref_primary_10_14789_jmj_JMJ22_0012_CR crossref_primary_10_1016_0165_4608_96_00071_4 crossref_primary_10_1016_S0338_9898_96_80030_8 crossref_primary_10_1371_journal_pone_0069026 crossref_primary_10_5694_j_1326_5377_1992_tb137441_x crossref_primary_10_1002_1097_0215_19960208_65_4_554__AID_IJC2910650402_3_0_CO_2_U crossref_primary_10_1016_S0165_4608_03_00105_5 crossref_primary_10_1002__SICI_1096_911X_199709_29_3_206__AID_MPO7_3_0_CO_2_H crossref_primary_10_1111_1346_8138_15488 crossref_primary_10_1136_bjo_77_10_662 crossref_primary_10_1002_cncr_31212 |
| Cites_doi | 10.1128/MCB.7.2.961 10.1038/348747a0 10.1016/S0161-6420(84)34127-6 10.1038/278261a0 10.1126/science.1978757 10.1126/science.2999980 10.1126/science.2144364 10.1016/0092-8674(91)90384-B 10.1056/NEJM198512263132605 10.1200/JCO.1990.8.3.443 10.1038/314633a0 10.1128/JVI.63.2.739-746.1989 10.1016/0888-7543(89)90129-8 10.1073/pnas.88.17.7825 10.1001/archopht.1990.01070030134045 10.1073/pnas.87.15.5863 10.1126/science.2144363 10.1038/342705a0 10.1073/pnas.84.21.7716 10.1126/science.2047879 10.1016/0092-8674(89)90045-7 10.1128/JVI.62.12.4737-4744.1988 10.1073/pnas.86.17.6783 10.1126/science.2144057 10.1007/BF00295569 10.1093/jnci/83.13.938 10.1073/pnas.74.3.1245 |
| ContentType | Journal Article |
| Copyright | 1993 INIST-CNRS Copyright Massachusetts Medical Society May 14, 1992 Copyright Massachusetts Medical Society, Publishing Division May 14, 1992 |
| Copyright_xml | – notice: 1993 INIST-CNRS – notice: Copyright Massachusetts Medical Society May 14, 1992 – notice: Copyright Massachusetts Medical Society, Publishing Division May 14, 1992 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 0TZ 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7T3 7TO 8FD FR3 H94 P64 RC3 7X8 |
| DOI | 10.1056/NEJM199205143262001 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Pharma and Biotech Premium PRO ProQuest Nursing & Allied Health Database ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection ProQuest Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection ProQuest Central (Alumni) ProQuest Central British Nursing Database ProQuest Central Essentials Biological Science Collection eLibrary AUTh Library subscriptions: ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection (Proquest) (PQ_SDU_P3) New England Journal of Medicine Biological Sciences ProQuest Consumer Health Database ProQuest Healthcare Administration Database PML(ProQuest Medical Library) Psychology Database (ProQuest) ProQuest research library ProQuest Science Journals Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic Human Genome Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Psychology Pharma and Biotech Premium PRO Research Library Prep ProQuest Central Student ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Research Library ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic Human Genome Abstracts Genetics Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database AIDS and Cancer Research Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest One Psychology Human Genome Abstracts MEDLINE ProQuest One Psychology |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 1308 |
| ExternalDocumentID | 2836466 10_1056_NEJM199205143262001 1565143 4353637 NJ199205143262001 |
| Genre | Original Article Research Support, U.S. Gov't, P.H.S Research Support, Non-U.S. Gov't Journal Article Case Reports General Information |
| GeographicLocations | United States Japan |
| GeographicLocations_xml | – name: Japan – name: United States |
| GroupedDBID | - 08R 0R 0WA 123 186 1KJ 1VV 2KS 2WC 34G 3O- 3V. 4 4.4 53G 55 5D0 5RE 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI 8RP 8WZ A6W AACLI AAEJM AAIKC AALRV AAPBV AAQQT AARDX AASXA AAUTI AAWTL ABACO ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQES ABQIJ ABUFD ABUWG ABWJO ACGFS ACGOD ACJLH ACNCT ACPRK ACPVT ACRZS ACTDY ACVYA ADBBV ADCBC AENEX AETEA AFDAS AFFDN AFFNX AFKRA AFMIJ AGNAY AHMBA AHVBC AIKQT AJJEV AJUXI AJYGW ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCU BENPR BHPHI BKEYQ BKNYI BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS EJD ET EX3 F5P FD8 FM. FYUFA G8K GJ GNUQQ GUQSH HCIFZ HZ IH2 J5H K-O K78 KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC MVM N9A NEJ NHB O0- O9- OHM OHT OK1 OMK OVD P-O P2P PADUT PQEST PQQKQ PQUKI PRINS PROAC PSQYO QZG RHI RWL RXW S6N SJFOW SJN TAE TAF TN5 TWZ U1N UCV UHB UKR VQA W2G WH7 WOW X X7M XFK XJT XZL YCJ YHZ YNT YQJ YZZ ZA5 ZGI ZHY ZKB ZKG ZXP --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 1CY 29N 36B 39C 41~ 68V 6TJ 9M8 AAJWC AAMNW AAUGY AAYOK ABCQX ABEFU ACKOT ACPFK ADRHT AFHKK AFOSN AGFXO AGHSJ AKALU CCPQU D0S F20 FA8 H13 HF~ HZ~ I4R IQODW MQT N4W NAPCQ PCD PSYQQ QJJ S10 SKT TEORI TUQ UBX UKHRP UMD UQL WHG WOQ XOL XYN YFH YQI YR2 YRY YYP YYQ ZCA ZR0 ZVN ~KM ABBLC ADUKH AERZD ALIPV CGR CUY CVF ECM EIF NPM AAYXX CITATION 0TZ 7XB BEC K0Y Q9U 7T3 7TO 8FD FR3 H94 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c535t-3ed5c49bee1de8ef54419822d60fd78a99074ce0839ea6ad3b228683228731613 |
| IEDL.DBID | 7X7 |
| ISSN | 0028-4793 |
| IngestDate | Fri Aug 16 23:42:20 EDT 2024 Sat Oct 05 06:05:20 EDT 2024 Tue Sep 24 23:27:24 EDT 2024 Tue Sep 24 20:38:10 EDT 2024 Thu Sep 26 18:31:43 EDT 2024 Sat Sep 28 07:26:08 EDT 2024 Sun Oct 29 17:09:22 EDT 2023 Wed Nov 11 00:32:51 EST 2020 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 20 |
| Keywords | Human Sarcoma Germ line Cytogenetics Mutation Malignant tumor Molecular biology Suppressor gene Carcinogenesis |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c535t-3ed5c49bee1de8ef54419822d60fd78a99074ce0839ea6ad3b228683228731613 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-3 ObjectType-Article-1 ObjectType-Feature-4 ObjectType-Report-2 |
| OpenAccessLink | https://www.nejm.org/doi/pdf/10.1056/NEJM199205143262001?articleTools=true |
| PMID | 1565143 |
| PQID | 1983448847 |
| PQPubID | 40644 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_72892643 proquest_miscellaneous_16675834 proquest_journals_223947857 proquest_journals_1983448847 crossref_primary_10_1056_NEJM199205143262001 pubmed_primary_1565143 pascalfrancis_primary_4353637 mms_nejm_10_1056_NEJM199205143262001 |
| ProviderPackageCode | DCD 7FN |
| PublicationCentury | 1900 |
| PublicationDate | 1992-05-14 |
| PublicationDateYYYYMMDD | 1992-05-14 |
| PublicationDate_xml | – month: 05 year: 1992 text: 1992-05-14 day: 14 |
| PublicationDecade | 1990 |
| PublicationPlace | Boston, MA |
| PublicationPlace_xml | – name: Boston, MA – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 1992 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | (r005) 1988; 48 (r028) 1987; 7 (r035) 1991; 83 (r008) 1990; 249 (r024) 1977; 74 (r013) 1987; 84 (r034) 1991; 51 (r009) 1988; 3 (r011) 1989; 57 (r029) 1990; 50 (r004) 1990; 348 Takebe H, Utsunomiya J, eds. Genetics of human tumors in Japan. Gann monograph on cancer research no. 35. Tokyo: Japan Scientific Societies Press, 1988. (r003) 1990; 250 (r014) 1989; 342 (r023) 1991; 88 (r001) 1985; 45 (r027) 1989; 45 (r016) 1990; 87 (r017) 1990; 108 (r022) 1990; 5 (r018) 1985; 313 (r031) 1988; 62 (r020) 1985; 314 (r012) 1990; 249 (r002) 1979; 52 (r006) 1979; 278 (r019) 1990; 8 (r021) 1989; 63 (r007) 1990; 249 (r030) 1991; 65 (r032) 1984; 91 (r010) 1991; 252 (r025) 1985; 230 (r015) 1989; 86 (r026) 1989; 5 1565147 - N Engl J Med. 1992 May 14;326(20):1350-2 Abramson (r032) 1984; 91 r020 Baker (r029) 1990; 50 r023 Tamboli (r017) 1990; 108 Iguchi-Ariga (r009) 1988; 3 Knudson (r001) 1985; 45 r018 r013 r035 r014 r015 r016 Li (r005) 1988; 48 Matlashewski (r028) 1987; 7 Tamura (r034) 1991; 51 r010 r011 Yandell (r027) 1989; 45 r033 r012 Crist (r019) 1990; 8 r030 r006 r007 r008 r002 r024 Kraiss (r031) 1988; 62 r003 r025 r004 r026 Hinds (r021) 1989; 63 Soussi (r022) 1990; 5 |
| References_xml | – volume: 52 start-page: 1 year: 1979 ident: r002 article-title: Genetics of retinoblastoma publication-title: Hum Genet – volume: 87 start-page: 5863 year: 1990 ident: r016 article-title: Mechanisms of p53 loss in human sarcomas publication-title: Proc Natl Acad Sci U S A – volume: 50 start-page: 7717 year: 1990 ident: r029 article-title: p53 Gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis publication-title: Cancer Res – volume: 314 start-page: 633 year: 1985 ident: r020 article-title: Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus publication-title: Nature – volume: 108 start-page: 128 year: 1990 ident: r017 article-title: The incidence of retinoblastoma in the United States: 1974 through 1985 publication-title: Arch Ophthalmol – volume: 74 start-page: 1245 year: 1977 ident: r024 article-title: Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants publication-title: Proc Natl Acad Sci USA – volume: 278 start-page: 261 year: 1979 ident: r006 article-title: T antigen is bound to a host protein in SV40-transformed cells publication-title: Nature – volume: 249 start-page: 1049 year: 1990 ident: r008 article-title: Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene publication-title: Science – volume: 57 start-page: 1083 year: 1989 ident: r011 article-title: The p53 proto-oncogene can act as a suppressor of transformation publication-title: Cell – volume: 230 start-page: 1350 year: 1985 ident: r025 article-title: Enzymatic amplification of betaglobin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia publication-title: Science – volume: 342 start-page: 705 year: 1989 ident: r014 article-title: Mutations in the p53 gene occur in diverse human tumour types publication-title: Nature – volume: 83 start-page: 93843 year: 1991 ident: r035 article-title: Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines publication-title: J Natl Cancer Inst – volume: 5 start-page: 945 year: 1990 ident: r022 article-title: Structural aspects of the p53 protein in relation to gene evolution publication-title: Oncogene – volume: 249 start-page: 912 year: 1990 ident: r012 article-title: Suppression of human colorectal carcinoma cell growth by wild-type p53 publication-title: Science – volume: 348 start-page: 747 year: 1990 ident: r004 article-title: Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li—Fraumeni syndrome publication-title: Nature – volume: 48 start-page: 5358 year: 1988 ident: r005 article-title: A cancer family syndrome in twenty-four kindreds publication-title: Cancer Res – volume: 313 start-page: 1637 year: 1985 ident: r018 article-title: Osteosarcoma: fifteen years later publication-title: N Engl J Med – volume: 62 start-page: 4737 year: 1988 ident: r031 article-title: Oligomerization of oncoprotein p53 publication-title: J Virol – volume: 5 start-page: 874 year: 1989 ident: r026 article-title: Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction publication-title: Genomics – volume: 45 start-page: 547 year: 1989 ident: r027 article-title: Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing publication-title: Am J Hum Genet – volume: 8 start-page: 443 year: 1990 ident: r019 article-title: Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II publication-title: J Clin Oncol – volume: 63 start-page: 739 year: 1989 ident: r021 article-title: Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation publication-title: J Virol – volume: 45 start-page: 1437 year: 1985 ident: r001 article-title: Hereditary cancer, oncogenes, and antioncogenes publication-title: Cancer Res – volume: 252 start-page: 1708 year: 1991 ident: r010 article-title: Identification of p53 as a sequence-specific DNA-binding protein publication-title: Science – volume: 88 start-page: 7825 year: 1991 ident: r023 article-title: Identification of a germ-line mutation in the p53 gene in a patient with intracranial ependymoma publication-title: Proc Natl Acad Sci U S A – volume: 249 start-page: 1046 year: 1990 ident: r007 article-title: Presence of a potent transcription activating sequence in the p53 protein publication-title: Science – volume: 84 start-page: 7716 year: 1987 ident: r013 article-title: Rearrangement of the p53 gene in human osteogenic sarcomas publication-title: Proc Natl Acad Sci U S A – volume: 7 start-page: 961 year: 1987 ident: r028 article-title: Primary structure polymorphism at amino acid residue 72 of human p53 publication-title: Mol Cell Biol – volume: 51 start-page: 3056 year: 1991 ident: r034 article-title: Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis publication-title: Cancer Res – volume: 250 start-page: 1233 year: 1990 ident: r003 article-title: Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms publication-title: Science – volume: 86 start-page: 6783 year: 1989 ident: r015 article-title: Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia publication-title: Proc Natl Acad Sci U S A – volume: 65 start-page: 765 year: 1991 ident: r030 article-title: Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation publication-title: Cell – volume: 91 start-page: 1351 year: 1984 ident: r032 article-title: Second nonocular tumors in retinoblastoma survivors: are they radiation-induced? publication-title: Ophthalmology – volume: 3 start-page: 509 year: 1988 ident: r009 article-title: Cloning of the p53-dependent origin of cellular DNA replication publication-title: Oncogene – volume: 48 start-page: 5358 year: 1988 ident: r005 publication-title: Cancer Res contributor: fullname: Li – volume: 7 start-page: 961 year: 1987 ident: r028 publication-title: Mol Cell Biol doi: 10.1128/MCB.7.2.961 contributor: fullname: Matlashewski – ident: r004 doi: 10.1038/348747a0 – volume: 3 start-page: 509 year: 1988 ident: r009 publication-title: Oncogene contributor: fullname: Iguchi-Ariga – volume: 91 start-page: 1351 year: 1984 ident: r032 publication-title: Ophthalmology doi: 10.1016/S0161-6420(84)34127-6 contributor: fullname: Abramson – ident: r006 doi: 10.1038/278261a0 – ident: r003 doi: 10.1126/science.1978757 – ident: r025 doi: 10.1126/science.2999980 – ident: r008 doi: 10.1126/science.2144364 – volume: 50 start-page: 7717 year: 1990 ident: r029 publication-title: Cancer Res contributor: fullname: Baker – ident: r030 doi: 10.1016/0092-8674(91)90384-B – ident: r018 doi: 10.1056/NEJM198512263132605 – volume: 8 start-page: 443 year: 1990 ident: r019 publication-title: J Clin Oncol doi: 10.1200/JCO.1990.8.3.443 contributor: fullname: Crist – ident: r020 doi: 10.1038/314633a0 – volume: 63 start-page: 739 year: 1989 ident: r021 publication-title: J Virol doi: 10.1128/JVI.63.2.739-746.1989 contributor: fullname: Hinds – volume: 5 start-page: 945 year: 1990 ident: r022 publication-title: Oncogene contributor: fullname: Soussi – volume: 51 start-page: 3056 year: 1991 ident: r034 publication-title: Cancer Res contributor: fullname: Tamura – ident: r026 doi: 10.1016/0888-7543(89)90129-8 – ident: r033 – ident: r023 doi: 10.1073/pnas.88.17.7825 – volume: 108 start-page: 128 year: 1990 ident: r017 publication-title: Arch Ophthalmol doi: 10.1001/archopht.1990.01070030134045 contributor: fullname: Tamboli – volume: 45 start-page: 547 year: 1989 ident: r027 publication-title: Am J Hum Genet contributor: fullname: Yandell – ident: r016 doi: 10.1073/pnas.87.15.5863 – ident: r007 doi: 10.1126/science.2144363 – ident: r014 doi: 10.1038/342705a0 – ident: r013 doi: 10.1073/pnas.84.21.7716 – ident: r010 doi: 10.1126/science.2047879 – ident: r011 doi: 10.1016/0092-8674(89)90045-7 – volume: 62 start-page: 4737 year: 1988 ident: r031 publication-title: J Virol doi: 10.1128/JVI.62.12.4737-4744.1988 contributor: fullname: Kraiss – volume: 45 start-page: 1437 year: 1985 ident: r001 publication-title: Cancer Res contributor: fullname: Knudson – ident: r015 doi: 10.1073/pnas.86.17.6783 – ident: r012 doi: 10.1126/science.2144057 – ident: r002 doi: 10.1007/BF00295569 – ident: r035 doi: 10.1093/jnci/83.13.938 – ident: r024 doi: 10.1073/pnas.74.3.1245 |
| SSID | ssj0000149 |
| Score | 1.929447 |
| Snippet | HEREDITARY mutations of tumor-suppressor genes have been correlated with a genetic predisposition to cancer, and several such genes have been linked to... Recent studies have identified germline mutations of the p53 tumor-suppressor gene in families with the Li-Fraumeni syndrome, a rare inherited disorder... Abstract Background Recent studies have identified germline mutations of the p53 tumor-suppressor gene in families with the Li--Fraumeni syndrome, a rare... We studied DNA from peripheral leukocytes of 196 patients with sarcoma and from 200 controls. Of the 196 patients with sarcoma, 15 were selected because they... BACKGROUNDRecent studies have identified germline mutations of the p53 tumor-suppressor gene in families with the Li-Fraumeni syndrome, a rare inherited... |
| SourceID | proquest crossref pubmed pascalfrancis mms |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1301 |
| SubjectTerms | Adolescent Adult Age Factors Amino acids Base Sequence Biological and medical sciences Bone cancer Bone tumors Brain cancer Breast cancer Cancer Cell cycle Child Codon Codons Cross-Sectional Studies Deoxyribonucleic acid DNA Family medical history Female Genes Genes, p53 Genetic testing Genetics Heterozygote Humans Infant Japan - epidemiology Leukocytes Male man Medical sciences Molecular Sequence Data Mutation Neoplastic Syndromes, Hereditary - epidemiology Neoplastic Syndromes, Hereditary - genetics Osteosarcoma - genetics p53 gene p53 Protein Patients Polymorphism, Genetic Sarcoma Sarcoma - epidemiology Sarcoma - genetics Splice junctions tumor suppressor genes Tumors United States - epidemiology |
| Title | Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma |
| URI | http://dx.doi.org/10.1056/NEJM199205143262001 https://www.ncbi.nlm.nih.gov/pubmed/1565143 https://www.proquest.com/docview/1983448847/abstract/ https://www.proquest.com/docview/223947857/abstract/ https://search.proquest.com/docview/16675834 https://search.proquest.com/docview/72892643 |
| Volume | 326 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB7BIqFeEI-ihqcPHBvtxq8kp2pBPIS0aEVB2p4ix3YOSElos_v_O5PH0qqFSw6byBvbM_Y3M873AVxIGeeRRUfiZmJCaVOL6yBXoVSF9D5PuTGU0J896Ltneb9Qiw24Hb6FoWOVw5rYLtSutpQjH3PS8I4TjN9NTkkAuxx_e_0ZknwUlVl7LY1N2Io4ogo07HgR_8Ej1ePgPpU00A8pPSbJeTqCSTzggtjZe3mYYYvaLMuGDkyaBses6MQu3kej7a50sws7PZxk027-92DDV_uwPesL5gfwgyiaTPthETOVYyQ3v_y1KlldsFtclAlkstmqq8c39CsCQjZXghEfNZuSFBGbd9yrDaOkLfuOrlGX5jM831w_Xd2FvZpCaJVQy1B4p6xMc-8j5xNfkPgYkfc5PSlcnJiUwmTrcfBSb7RxIuc80eTwCalbReIQRlVd-S_AImeJdCeXBW5ukvNcGMENNqwnruBaBPB1GMDstSPNyNpit9LZf8Y7gAsc5KzyL-XHj53-NQvrphHxCS3iAE6GWcl6R2wy7KLACBT34ACO_729tqoAztd30cGoamIqX6-wBU0xlZDvPxFj0Iq4Ert92NnCW6cRLuP7H33418fwqTsDrMJInsAIrcCfItJZ5metFeM1uYrOYOvy-mH--Bv9RPdc |
| link.rule.ids | 315,786,790,12083,12250,21416,27957,27958,31754,31755,33301,33302,33779,33780,43345,43614,43840,74102,74371,74659 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB4BlVouiNKipizFB46N2PiV5FStUOnyWIQESPQUObFzqJRkIbv_n5nEWUAFrnHkxI_xfPaMvw_gUMo4jwo0JG7GJpRFWuA6yFUoVSmdy1NuDB3ozy719Fae3ak7n5vT-rTKYU3sFmrbFHRGfsRJwztOVPxrfh-SaBQFV72Cxjp8kAL9DF0UP46esUd59OsPkAbSIaWPSGieEi-J_VsQJ7sXhRkc03pVtZQmaVrsqbKXuHgbg3a-6GQbtjyIZJN-1D_Dmqt34OPMh8m_wF8iZjLddSJmastIZH7xsKxYU7I_uBQTtGSzZR-Fb-kpwkB2pQQjFmo2IQEidtUzrraMjmrZNRpEU5mvcHvy--Z4GnoNhbBQQi1C4awqZJo7F1mXuJIkx4iyz-pxaePEpLQ5LhwCsdQZbazIOU80mXlCmlaR2IWNuqndN2CRLYhqJ5clujTJeS6M4AYr1mNbci0C-Dl0YDbvqTKyLsStdPZKfwdwiJ2c1e5f9f5r-y9GYVU14jyhRRzAaBiVzJtfm2ETBe470fMGsPd_8WouBXCwKkWzoliJqV2zxBo07aSEfPuNGLeqiCax2bv9XHhqNIJk_P_v7376AD5Nb2YX2cXp5fkebPZZwCqM5Ag2cEa4fcQ6i_xHN6MfAb6R8_M |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB4VKiEuCEoRKS8fOBKx8SvJCaG2C21ZtFKLtD1FTuwckJIsze7_ZyZxtiAe1yTyxs6M5xvP7PcBnEoZ51GBjsTNyISySAvcB7kKpSqlc3nKjaED_cmtvr6TP2dq5imFWt9WOeyJ3UZtm4LOyM85aXjHCebvpe-KmH4bX8wfQhKQokKrV9NYg48YJEckZhDP4idMUh4J-8OkgYBI6XMSnacmTGICF8TP7gVihiC1VlUttUyaFlet7OUu3sajXVwab8OWB5TssreAHfjg6k-wMfEl8134SyRNpvtrETO1ZSQ4v_i3rFhTsivclglmssmyr8i3dBUhIZsqwYiRml2SGBGb9uyrLaNjW_YbnaOpzGe4G3__8_U69HoKYaGEWoTCWVXINHcusi5xJcmPEX2f1aPSxolJKVEuHIKy1BltrMg5TzS5fEL6VpHYg_W6qd0-sMgWRLuTyxLDm-Q8F0ZwgwPrkS25FgGcDQuYzXvajKwrdyudvbLeAZziIme1u6_ef-zo2VdYDY2YT2gRB3A4fJXMu2Kb4RQF5qAYhQM4eHl7ZVcBnKzuootR3cTUrlniCJqyKiHffiLGtBWRJU57r7eF_5NGwIzv_-Xdnz6BDTTm7ObH7a8D2OwbglUYyUNYR4NwRwh7FvlxZ9CP0V74VA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prevalence+and+spectrum+of+germline+mutations+of+the+p53+gene+among+patients+with+sarcoma&rft.jtitle=The+New+England+journal+of+medicine&rft.au=Toguchida%2C+J&rft.au=Yamaguchi%2C+T&rft.au=Dayton%2C+SH&rft.au=Beauchamp%2C+R+L&rft.date=1992-05-14&rft.issn=0028-4793&rft.volume=326&rft.issue=20&rft.spage=1301&rft.epage=1308&rft_id=info:doi/10.1056%2FNEJM199205143262001&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |