Heartland Virus Epidemiology, Vector Association, and Disease Potential
First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Fi...
Saved in:
| Published in | Viruses Vol. 10; no. 9; p. 498 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
14.09.2018
MDPI |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Field isolations of HRTV from several life stages of unfed, host-seeking Amblyomma americanum, the lone star tick, implicated it as a putative vector capable of transstadial transmission. Laboratory vector competence assessments confirmed transstadial transmission of HRTV, demonstrated vertical infection, and showed co-feeding infection between A. americanum. A vertical infection rate of 33% from adult females to larvae in the laboratory was observed, while only one of 386 pools of molted nymphs (1930) reared from co-feeding larvae was positive for HRTV (maximum-likelihood estimate of infection rate = 0.52/1000). Over 35 human HRTV cases, all within the distribution range of A. americanum, have been documented. Serological testing of wildlife in areas near the index human cases, as well as in widely separated regions of the eastern United States where A. americanum occur, indicated many potential hosts such as raccoons and white-tailed deer. Attempts, however, to experimentally infect mice, rabbits, hamsters, chickens, raccoons, goats, and deer failed to produce detectable viremia. Immune-compromised mice and hamsters are the only susceptible models. Vertical infection augmented by co-feeding transmission could play a role in maintaining the virus in nature. A more complete assessment of the natural transmission cycle of HRTV coupled with serosurveys and enhanced HRTV disease surveillance are needed to better understand transmission dynamics and human health risks. |
|---|---|
| AbstractList | First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Field isolations of HRTV from several life stages of unfed, host-seeking
Amblyomma americanum
, the lone star tick, implicated it as a putative vector capable of transstadial transmission. Laboratory vector competence assessments confirmed transstadial transmission of HRTV, demonstrated vertical infection, and showed co-feeding infection between
A. americanum
. A vertical infection rate of 33% from adult females to larvae in the laboratory was observed, while only one of 386 pools of molted nymphs (1930) reared from co-feeding larvae was positive for HRTV (maximum-likelihood estimate of infection rate = 0.52/1000). Over 35 human HRTV cases, all within the distribution range of
A. americanum
, have been documented. Serological testing of wildlife in areas near the index human cases, as well as in widely separated regions of the eastern United States where
A. americanum
occur, indicated many potential hosts such as raccoons and white-tailed deer. Attempts, however, to experimentally infect mice, rabbits, hamsters, chickens, raccoons, goats, and deer failed to produce detectable viremia. Immune-compromised mice and hamsters are the only susceptible models. Vertical infection augmented by co-feeding transmission could play a role in maintaining the virus in nature. A more complete assessment of the natural transmission cycle of HRTV coupled with serosurveys and enhanced HRTV disease surveillance are needed to better understand transmission dynamics and human health risks. First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Field isolations of HRTV from several life stages of unfed, host-seeking Amblyomma americanum, the lone star tick, implicated it as a putative vector capable of transstadial transmission. Laboratory vector competence assessments confirmed transstadial transmission of HRTV, demonstrated vertical infection, and showed co-feeding infection between A. americanum. A vertical infection rate of 33% from adult females to larvae in the laboratory was observed, while only one of 386 pools of molted nymphs (1930) reared from co-feeding larvae was positive for HRTV (maximum-likelihood estimate of infection rate = 0.52/1000). Over 35 human HRTV cases, all within the distribution range of A. americanum, have been documented. Serological testing of wildlife in areas near the index human cases, as well as in widely separated regions of the eastern United States where A. americanum occur, indicated many potential hosts such as raccoons and white-tailed deer. Attempts, however, to experimentally infect mice, rabbits, hamsters, chickens, raccoons, goats, and deer failed to produce detectable viremia. Immune-compromised mice and hamsters are the only susceptible models. Vertical infection augmented by co-feeding transmission could play a role in maintaining the virus in nature. A more complete assessment of the natural transmission cycle of HRTV coupled with serosurveys and enhanced HRTV disease surveillance are needed to better understand transmission dynamics and human health risks. First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Field isolations of HRTV from several life stages of unfed, host-seeking Amblyomma americanum, the lone star tick, implicated it as a putative vector capable of transstadial transmission. Laboratory vector competence assessments confirmed transstadial transmission of HRTV, demonstrated vertical infection, and showed co-feeding infection between A. americanum. A vertical infection rate of 33% from adult females to larvae in the laboratory was observed, while only one of 386 pools of molted nymphs (1930) reared from co-feeding larvae was positive for HRTV (maximum-likelihood estimate of infection rate = 0.52/1000). Over 35 human HRTV cases, all within the distribution range of A. americanum, have been documented. Serological testing of wildlife in areas near the index human cases, as well as in widely separated regions of the eastern United States where A. americanum occur, indicated many potential hosts such as raccoons and white-tailed deer. Attempts, however, to experimentally infect mice, rabbits, hamsters, chickens, raccoons, goats, and deer failed to produce detectable viremia. Immune-compromised mice and hamsters are the only susceptible models. Vertical infection augmented by co-feeding transmission could play a role in maintaining the virus in nature. A more complete assessment of the natural transmission cycle of HRTV coupled with serosurveys and enhanced HRTV disease surveillance are needed to better understand transmission dynamics and human health risks.First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Field isolations of HRTV from several life stages of unfed, host-seeking Amblyomma americanum, the lone star tick, implicated it as a putative vector capable of transstadial transmission. Laboratory vector competence assessments confirmed transstadial transmission of HRTV, demonstrated vertical infection, and showed co-feeding infection between A. americanum. A vertical infection rate of 33% from adult females to larvae in the laboratory was observed, while only one of 386 pools of molted nymphs (1930) reared from co-feeding larvae was positive for HRTV (maximum-likelihood estimate of infection rate = 0.52/1000). Over 35 human HRTV cases, all within the distribution range of A. americanum, have been documented. Serological testing of wildlife in areas near the index human cases, as well as in widely separated regions of the eastern United States where A. americanum occur, indicated many potential hosts such as raccoons and white-tailed deer. Attempts, however, to experimentally infect mice, rabbits, hamsters, chickens, raccoons, goats, and deer failed to produce detectable viremia. Immune-compromised mice and hamsters are the only susceptible models. Vertical infection augmented by co-feeding transmission could play a role in maintaining the virus in nature. A more complete assessment of the natural transmission cycle of HRTV coupled with serosurveys and enhanced HRTV disease surveillance are needed to better understand transmission dynamics and human health risks. First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne phlebovirus producing similar symptoms in China, Korea, and Japan. Field isolations of HRTV from several life stages of unfed, host-seeking , the lone star tick, implicated it as a putative vector capable of transstadial transmission. Laboratory vector competence assessments confirmed transstadial transmission of HRTV, demonstrated vertical infection, and showed co-feeding infection between . A vertical infection rate of 33% from adult females to larvae in the laboratory was observed, while only one of 386 pools of molted nymphs (1930) reared from co-feeding larvae was positive for HRTV (maximum-likelihood estimate of infection rate = 0.52/1000). Over 35 human HRTV cases, all within the distribution range of , have been documented. Serological testing of wildlife in areas near the index human cases, as well as in widely separated regions of the eastern United States where occur, indicated many potential hosts such as raccoons and white-tailed deer. Attempts, however, to experimentally infect mice, rabbits, hamsters, chickens, raccoons, goats, and deer failed to produce detectable viremia. Immune-compromised mice and hamsters are the only susceptible models. Vertical infection augmented by co-feeding transmission could play a role in maintaining the virus in nature. A more complete assessment of the natural transmission cycle of HRTV coupled with serosurveys and enhanced HRTV disease surveillance are needed to better understand transmission dynamics and human health risks. |
| Author | Brault, Aaron C. Duggal, Nisha K. Eisen, Rebecca J. Savage, Harry M. Staples, J. Erin |
| AuthorAffiliation | 2 Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Room 2033, Blacksburg, VA 24061, USA; nduggal@vt.edu 1 Division of Vector-Borne Diseases, USA Centers for Disease Control and Prevention, National Center for Emerging Zoonotic Infectious Diseases, 3156 Rampart Road, Fort Collins, CO 80521, USA; hms1@cdc.gov (H.M.S.); dyn2@cdc.gov (R.J.E.); auv1@cdc.gov (J.E.S.) |
| AuthorAffiliation_xml | – name: 1 Division of Vector-Borne Diseases, USA Centers for Disease Control and Prevention, National Center for Emerging Zoonotic Infectious Diseases, 3156 Rampart Road, Fort Collins, CO 80521, USA; hms1@cdc.gov (H.M.S.); dyn2@cdc.gov (R.J.E.); auv1@cdc.gov (J.E.S.) – name: 2 Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Room 2033, Blacksburg, VA 24061, USA; nduggal@vt.edu |
| Author_xml | – sequence: 1 givenname: Aaron C. orcidid: 0000-0001-5801-3021 surname: Brault fullname: Brault, Aaron C. – sequence: 2 givenname: Harry M. surname: Savage fullname: Savage, Harry M. – sequence: 3 givenname: Nisha K. surname: Duggal fullname: Duggal, Nisha K. – sequence: 4 givenname: Rebecca J. surname: Eisen fullname: Eisen, Rebecca J. – sequence: 5 givenname: J. Erin surname: Staples fullname: Staples, J. Erin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30223439$$D View this record in MEDLINE/PubMed |
| BookMark | eNplkl1LHDEUhkOx1I_2on-gDPSmgqtn8jWTm4JYv0CwF-ptyCQn2yyzk20yI_jvm3VV1F4lJO95eN9zzi7ZGuKAhHyt4ZAxBUf3NYACrtoPZKdWSs24qsXWq_s22c15ASClguYT2WZAKeNM7ZDzCzRp7M3gqruQplydroLDZYh9nD8cVHdox5iq45yjDWYMcTio1tpfIaPJWP2OIw5jMP1n8tGbPuOXp3OP3J6d3pxczK6uzy9Pjq9mVjAxziioxtYcOEopJJOtZ1wx2clWSpAOHbeeU8eFlN555j1rSrDGogeFKDq2Ry43XBfNQq9SWJr0oKMJ-vEhprkueYLtUdvOWI-Klga0nDbYMma61oumo04w7grr54a1mrolOluSJNO_gb79GcIfPY_3WtaSt5QXwI8nQIp_J8yjXoZssS_txDhlTWtQjAmgUKTf30kXcUpDaVVRUbaOD2vgt9eOXqw8z6sIjjYCm2LOCb22YXycSzEYel2DXm-EftmIUrH_ruIZ-r_2H8mSs90 |
| CitedBy_id | crossref_primary_10_1186_s13071_022_05416_2 crossref_primary_10_1093_jme_tjad060 crossref_primary_10_3201_eid2803_210973 crossref_primary_10_3390_v14081668 crossref_primary_10_1080_21505594_2024_2348252 crossref_primary_10_3201_eid2905_221488 crossref_primary_10_3390_zoonoticdis3030016 crossref_primary_10_1016_j_coviro_2022_101278 crossref_primary_10_3389_fmicb_2024_1509749 crossref_primary_10_1093_ofid_ofaa125 crossref_primary_10_3390_v13020299 crossref_primary_10_3390_v11080703 crossref_primary_10_1128_CMR_00083_18 crossref_primary_10_3201_eid2607_200110 crossref_primary_10_3106_ms2023_0006 crossref_primary_10_3201_eid2802_211532 crossref_primary_10_1016_j_dci_2021_104012 crossref_primary_10_1093_jme_tjac121 crossref_primary_10_1016_j_antiviral_2020_104993 crossref_primary_10_1093_cid_ciz449 crossref_primary_10_1002_jmv_27618 crossref_primary_10_1016_j_clinmicnews_2020_05_001 crossref_primary_10_1128_jvi_00049_22 crossref_primary_10_1128_JVI_01394_19 crossref_primary_10_1186_s12915_022_01463_4 crossref_primary_10_3390_microorganisms12020286 crossref_primary_10_1038_s41390_023_02974_8 crossref_primary_10_1093_jme_tjae149 crossref_primary_10_18794_aams_183663 crossref_primary_10_3390_microorganisms9030663 crossref_primary_10_3201_eid2804_211540 crossref_primary_10_1016_j_micpath_2022_105592 crossref_primary_10_1089_vbz_2021_0082 crossref_primary_10_1186_s13071_025_06674_6 crossref_primary_10_1128_jvi_00769_24 crossref_primary_10_2217_fvl_2019_0149 crossref_primary_10_3390_pathogens9110915 crossref_primary_10_1016_j_virol_2020_10_006 crossref_primary_10_1016_j_heliyon_2024_e26118 crossref_primary_10_1371_journal_pntd_0010967 crossref_primary_10_1093_infdis_jiac338 crossref_primary_10_1186_s12985_022_01924_w crossref_primary_10_1093_jme_tjab064 crossref_primary_10_1089_vbz_2020_2670 crossref_primary_10_3390_v12090933 crossref_primary_10_1007_s00436_020_07033_3 crossref_primary_10_1097_QCO_0000000000000924 crossref_primary_10_1128_jvi_00132_24 crossref_primary_10_1038_s41598_025_94416_0 crossref_primary_10_1186_s12879_025_10661_8 crossref_primary_10_1109_TIM_2024_3352709 crossref_primary_10_3389_fmicb_2023_1185829 crossref_primary_10_1016_j_actatropica_2024_107388 crossref_primary_10_1093_cid_ciz451 crossref_primary_10_1089_vim_2025_0004 crossref_primary_10_1371_journal_pntd_0006982 crossref_primary_10_1093_cid_ciaa647 crossref_primary_10_3390_pathogens11121505 crossref_primary_10_35366_102233 crossref_primary_10_1016_j_animal_2021_100241 crossref_primary_10_3390_vaccines12121403 crossref_primary_10_1093_jme_tjaa087 crossref_primary_10_7601_mez_70_3 crossref_primary_10_1016_j_ttbdis_2022_102080 crossref_primary_10_1111_pim_12815 crossref_primary_10_1016_j_virs_2022_08_009 crossref_primary_10_3390_ijerph17218285 crossref_primary_10_3390_v15040940 crossref_primary_10_1016_j_onehlt_2022_100478 crossref_primary_10_1016_j_vetpar_2021_109392 crossref_primary_10_1089_vbz_2024_0107 crossref_primary_10_3201_eid3012_240646 crossref_primary_10_3390_microorganisms11010209 crossref_primary_10_1093_clinchem_hvaa040 crossref_primary_10_3390_microorganisms11061590 crossref_primary_10_3390_zoonoticdis2030013 crossref_primary_10_1016_j_virusres_2023_199301 crossref_primary_10_1038_s41598_023_40397_x crossref_primary_10_1080_22221751_2024_2348510 crossref_primary_10_3389_fmicb_2022_846884 |
| Cites_doi | 10.3201/eid2112.141303 10.1136/jclinpath-2015-203417 10.1128/JVI.02617-13 10.1128/JVI.75.3.1371-1377.2001 10.4269/ajtmh.14-0702 10.3201/eid1806.111345 10.1016/0882-4010(87)90011-8 10.3201/eid2212.160472 10.1093/jme/tjw028 10.1371/journal.pntd.0001623 10.4269/ajtmh.15-0330 10.4269/ajtmh.15-0473 10.1016/j.vetmic.2006.11.008 10.1016/j.virol.2007.03.057 10.1186/s40249-018-0417-4 10.1097/MD.0000000000004476 10.1016/S1473-3099(18)30293-7 10.1093/jmedent/44.5.732 10.1016/j.vaccine.2012.08.003 10.1093/jme/tjw080 10.1093/infdis/jit061 10.1093/infdis/jis748 10.1093/cid/ciu434 10.1099/0022-1317-70-7-1895 10.1093/cid/cir776 10.1099/vir.0.041053-0 10.1128/JVI.02277-13 10.1371/journal.pone.0062083 10.1371/journal.pntd.0004092 10.4269/ajtmh.11-0760 10.1016/j.vetmic.2007.07.031 10.1002/(SICI)1096-9071(199606)49:2<83::AID-JMV2>3.0.CO;2-F 10.1146/annurev.ento.48.091801.112728 10.1371/journal.pntd.0003267 10.1016/j.ttbdis.2016.08.005 10.1111/j.1365-2915.1993.tb00674.x 10.4161/mabs.2.3.11676 10.1093/infdis/jis472 10.1017/ice.2017.61 10.1128/JVI.01056-15 10.1056/NEJMoa1010095 10.4269/ajtmh.13-0423 10.1371/journal.ppat.1002369 10.1007/BF01314117 10.1093/infdis/jiu564 10.1016/j.jviromet.2005.02.008 10.1371/journal.pntd.0005264 10.1007/s00705-017-3358-5 10.1093/cid/cit530 10.4269/ajtmh.17-0963 10.1128/CDLI.6.1.55-60.1999 10.1128/JVI.01942-16 10.1073/pnas.98.2.664 10.1073/pnas.1120246109 10.1016/j.virol.2017.08.004 10.3201/eid2110.150380 10.3201/eid2405.171802 10.4269/ajtmh.15-0580 10.1017/S0022172400065414 10.1126/science.3616608 10.3201/eid1603.090911 10.3389/fmicb.2017.00104 10.1093/cid/ciw766 10.1371/journal.pone.0165207 10.1016/j.virol.2009.09.003 10.1016/S1473-3099(14)70718-2 10.1128/JVI.79.9.5606-5615.2005 10.1099/vir.0.035105-0 10.1093/jme/tjx251 10.1128/JVI.02704-14 10.1128/CVI.00222-13 10.1128/JVI.00612-12 10.1056/NEJMoa1203378 10.3201/eid1908.130165 10.3201/eid2006.140003 10.3201/eid2110.150126 10.4269/ajtmh.13-0209 |
| ContentType | Journal Article |
| Copyright | 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 by the authors. 2018 |
| Copyright_xml | – notice: 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2018 by the authors. 2018 |
| DBID | AAYXX CITATION NPM 3V. 7U9 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.3390/v10090498 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef Publicly Available Content Database MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1999-4915 |
| ExternalDocumentID | oai_doaj_org_article_cbacfe924918427e833ab8f57b2d534d PMC6164824 30223439 10_3390_v10090498 |
| Genre | Journal Article Review |
| GeographicLocations | United States--US Missouri |
| GeographicLocations_xml | – name: Missouri – name: United States--US |
| GroupedDBID | --- 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACUHS ADRAZ AFKRA AFPKN AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS BBNVY BENPR BHPHI BPHCQ BVXVI CCPQU CITATION DIK E3Z EBD ESX FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IPNFZ KQ8 LK8 M1P M48 M7P MODMG M~E O5R O5S OK1 PGMZT PHGZM PHGZT PIMPY PPXIY PQGLB PQQKQ PROAC PSQYO RIG RPM TR2 TUS UKHRP 3V. NPM 7U9 7XB 8FK AZQEC DWQXO GNUQQ H94 K9. PJZUB PKEHL PQEST PQUKI PRINS 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c535t-2097c1404e6656368f34936b686606ded4cf42d4566fdf3ff379047cef09ee5b3 |
| IEDL.DBID | M48 |
| ISSN | 1999-4915 |
| IngestDate | Wed Aug 27 01:26:08 EDT 2025 Thu Aug 21 18:13:12 EDT 2025 Tue Aug 05 11:35:30 EDT 2025 Fri Jul 25 11:58:02 EDT 2025 Wed Feb 19 02:42:15 EST 2025 Thu Jul 10 10:13:38 EDT 2025 Thu Apr 24 23:10:58 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Heartland virus Amblyomma americanum transmission thrombocytopenia lone star tick |
| Language | English |
| License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c535t-2097c1404e6656368f34936b686606ded4cf42d4566fdf3ff379047cef09ee5b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0001-5801-3021 |
| OpenAccessLink | https://doaj.org/article/cbacfe924918427e833ab8f57b2d534d |
| PMID | 30223439 |
| PQID | 2123866004 |
| PQPubID | 2032319 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_cbacfe924918427e833ab8f57b2d534d pubmedcentral_primary_oai_pubmedcentral_nih_gov_6164824 proquest_miscellaneous_2109335020 proquest_journals_2123866004 pubmed_primary_30223439 crossref_citationtrail_10_3390_v10090498 crossref_primary_10_3390_v10090498 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-09-14 |
| PublicationDateYYYYMMDD | 2018-09-14 |
| PublicationDate_xml | – month: 09 year: 2018 text: 2018-09-14 day: 14 |
| PublicationDecade | 2010 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Viruses |
| PublicationTitleAlternate | Viruses |
| PublicationYear | 2018 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Muehlenbachs (ref_39) 2014; 59 Hermance (ref_80) 2015; 89 Hwang (ref_66) 2017; 8 Childs (ref_36) 2003; 48 Chen (ref_72) 2012; 93 Westover (ref_75) 2017; 511 Gowen (ref_76) 2017; 91 Panella (ref_58) 2015; 92 Oh (ref_40) 2016; 95 Godsey (ref_50) 2016; 53 Swanepoel (ref_20) 1986; 97 Fill (ref_38) 2017; 64 Jones (ref_82) 1989; 70 Zhuang (ref_83) 2018; 7 Tugwell (ref_61) 1962; 35 Kim (ref_41) 2016; 69 ref_68 ref_65 ref_64 Liu (ref_43) 2014; 14 Pastula (ref_28) 2014; 63 Liu (ref_44) 2013; 57 Nakamura (ref_57) 1985; 86 ref_29 Paweska (ref_17) 2008; 127 Springer (ref_35) 2015; 93 ref_27 Zhao (ref_62) 2012; 18 Cui (ref_63) 2013; 88 Savage (ref_48) 2018; 55 Luo (ref_49) 2015; 21 Chen (ref_31) 2017; 38 Mendenhall (ref_78) 2009; 395 Magurano (ref_18) 1999; 6 Paweska (ref_16) 2005; 127 Liang (ref_51) 2014; 90 Jiang (ref_52) 2012; 28 Clarke (ref_69) 2018; 98 Matsuno (ref_70) 2017; 8 Schwarz (ref_19) 1996; 49 Mitzel (ref_54) 2007; 365 Qu (ref_73) 2012; 86 Riemersma (ref_59) 2015; 21 Gai (ref_32) 2012; 206 Jin (ref_77) 2015; 211 Guo (ref_21) 2013; 20 Fafetine (ref_15) 2007; 121 ref_30 Calvert (ref_13) 2015; 93 Ikegami (ref_25) 2005; 79 Liu (ref_74) 2014; 88 Walter (ref_6) 2011; 92 Allan (ref_53) 2010; 16 Labuda (ref_81) 1993; 7 Lorenzo (ref_14) 2010; 2 Dahlgren (ref_67) 2016; 94 Adams (ref_5) 2017; 162 Carlson (ref_37) 2018; 24 Karlberg (ref_22) 2012; 30 Jones (ref_56) 1987; 237 Gauci (ref_10) 2015; 21 Zivcec (ref_23) 2013; 207 Bridgen (ref_24) 2001; 98 ref_45 McMullan (ref_1) 2012; 367 Gai (ref_34) 2012; 54 ref_42 Savage (ref_47) 2016; 53 Troughton (ref_55) 2007; 44 Wang (ref_11) 2014; 20 ref_84 ref_3 Jin (ref_71) 2012; 109 Xing (ref_60) 2013; 19 Yu (ref_2) 2011; 364 Bouloy (ref_26) 2001; 75 Tang (ref_33) 2013; 207 Calvert (ref_12) 2016; 22 ref_4 Savage (ref_46) 2013; 89 ref_7 Matsuno (ref_8) 2015; 89 Mourya (ref_9) 2014; 88 Pifat (ref_79) 1987; 3 29664369 - Emerg Infect Dis. 2018 May;24(5):893-897 21865443 - J Gen Virol. 2011 Nov;92(Pt 11):2467-84 24343883 - Am J Trop Med Hyg. 2014 Feb;90(2):256-9 26583599 - Emerg Infect Dis. 2015 Dec;21(12):2246-8 28397631 - Infect Control Hosp Epidemiol. 2017 Jun;38(6):760-762 8991940 - J Med Virol. 1996 Jun;49(2):83-6 15893560 - J Virol Methods. 2005 Jul;127(1):10-8 23965284 - Clin Infect Dis. 2013 Nov;57(9):1292-9 29730989 - Infect Dis Poverty. 2018 May 7;7(1):45 19783024 - Virology. 2009 Dec 5;395(1):143-51 9874664 - Clin Diagn Lab Immunol. 1999 Jan;6(1):55-60 3537118 - J Hyg (Lond). 1986 Oct;97(2):317-29 29488458 - Am J Trop Med Hyg. 2018 Apr;98(4):1194-1196 27776187 - PLoS One. 2016 Oct 24;11(10):e0165207 22357748 - J Gen Virol. 2012 Jun;93(Pt 6):1288-93 17187944 - Vet Microbiol. 2007 Mar 31;121(1-2):29-38 22095565 - Clin Infect Dis. 2012 Jan 15;54(2):249-52 28865344 - Virology. 2017 Nov;511:175-183 23339197 - Am J Trop Med Hyg. 2013 Mar;88(3):510-2 28194148 - Front Microbiol. 2017 Jan 30;8:104 28033338 - PLoS Negl Trop Dis. 2016 Dec 29;10(12):e0005264 27032416 - J Med Entomol. 2016 May;53(3):607-612 8481537 - Med Vet Entomol. 1993 Apr;7(2):193-6 29365128 - J Med Entomol. 2018 May 4;55(3):701-705 25326554 - J Infect Dis. 2015 Mar 15;211(6):915-25 22931317 - N Engl J Med. 2012 Aug 30;367(9):834-41 23863504 - Clin Vaccine Immunol. 2013 Sep;20(9):1426-32 26485390 - PLoS Negl Trop Dis. 2015 Oct 20;9(10):e0004092 30054190 - Lancet Infect Dis. 2018 Oct;18(10):1127-1137 24837566 - Lancet Infect Dis. 2014 Aug;14(8):763-772 25870419 - Am J Trop Med Hyg. 2015 Jun;92(6):1163-7 27927857 - Clin Infect Dis. 2017 Feb 15;64(4):510-512 25330383 - PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3267 27330103 - J Med Entomol. 2016 Jun 20;:null 22850122 - J Infect Dis. 2012 Oct 1;206(7):1095-102 20400862 - MAbs. 2010 May-Jun;2(3):275-84 12414740 - Annu Rev Entomol. 2003;48:307-37 27869591 - Emerg Infect Dis. 2016 Dec;22(12):2070-2077 24257618 - J Virol. 2014 Feb;88(3):1781-6 23417661 - J Infect Dis. 2013 Jun 15;207(12):1909-21 22545170 - PLoS Negl Trop Dis. 2012;6(4):e1623 27495089 - Medicine (Baltimore). 2016 Aug;95(31):e4476 17915502 - J Med Entomol. 2007 Sep;44(5):732-40 22114553 - PLoS Pathog. 2011 Nov;7(11):e1002369 21410387 - N Engl J Med. 2011 Apr 21;364(16):1523-32 27542506 - Ticks Tick Borne Dis. 2017 Jan;8(1):9-12 23637969 - PLoS One. 2013 Apr 29;8(4):e62083 11209062 - Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):664-9 25995246 - J Virol. 2015 Aug;89(15):7852-60 24917656 - Clin Infect Dis. 2014 Sep 15;59(6):845-50 26503270 - Am J Trop Med Hyg. 2016 Jan;94(1):35-42 22902680 - Vaccine. 2012 Sep 28;30(44):6225-9 22623799 - J Virol. 2012 Aug;86(16):8388-401 24670929 - MMWR Morb Mortal Wkly Rep. 2014 Mar 28;63(12):270-1 26217042 - Am J Trop Med Hyg. 2015 Oct;93(4):875-90 23966016 - Emerg Infect Dis. 2013;19(9):1487-9 2864037 - Arch Virol. 1985;86(1-2):109-20 17884306 - Vet Microbiol. 2008 Feb 5;127(1-2):21-8 20202418 - Emerg Infect Dis. 2010 Mar;16(3):433-40 24856477 - Emerg Infect Dis. 2014 Jun;20(6):1040-3 2544668 - J Gen Virol. 1989 Jul;70 ( Pt 7):1895-8 27881648 - J Virol. 2017 Jan 18;91(3) 17490700 - Virology. 2007 Sep 1;365(2):410-8 24390329 - J Virol. 2014 Mar;88(6):3605-9 11152510 - J Virol. 2001 Feb;75(3):1371-7 3616608 - Science. 1987 Aug 14;237(4816):775-7 26908283 - J Clin Pathol. 2016 Jun;69(6):537-41 25339769 - J Virol. 2015 Jan;89(1):594-604 22764528 - Bing Du Xue Bao. 2012 May;28(3):252-7 22608264 - Emerg Infect Dis. 2012 Jun;18(6):963-5 23878186 - Am J Trop Med Hyg. 2013 Sep;89(3):445-52 2462155 - Microb Pathog. 1987 Dec;3(6):409-22 23225899 - J Infect Dis. 2013 Mar 1;207(5):736-9 28434098 - Arch Virol. 2017 Aug;162(8):2505-2538 22665769 - Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10053-8 26503274 - Am J Trop Med Hyg. 2015 Dec;93(6):1338-40 26401988 - Emerg Infect Dis. 2015 Oct;21(10):1830-3 26402039 - Emerg Infect Dis. 2015 Oct;21(10):1770-6 15827175 - J Virol. 2005 May;79(9):5606-15 |
| References_xml | – volume: 21 start-page: 2246 year: 2015 ident: ref_10 article-title: Hunter Island group phlebovirus in ticks, Australia publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2112.141303 – volume: 69 start-page: 537 year: 2016 ident: ref_41 article-title: Bone marrow findings in severe fever with thrombocytopenia syndrome: Prominent haemophagocytosis and its implication in haemophagocytic lymphohistiocytosis publication-title: J. Clin. Pathol. doi: 10.1136/jclinpath-2015-203417 – volume: 88 start-page: 3605 year: 2014 ident: ref_9 article-title: Malsoor virus, a novel bat phlebovirus, is closely related to Severe Fever with Thrombocytopenia Syndrome virus and Heartland virus publication-title: J. Virol. doi: 10.1128/JVI.02617-13 – volume: 75 start-page: 1371 year: 2001 ident: ref_26 article-title: Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs publication-title: J. Virol. doi: 10.1128/JVI.75.3.1371-1377.2001 – volume: 92 start-page: 1163 year: 2015 ident: ref_58 article-title: Serological investigation of Heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012–2013 publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.14-0702 – volume: 18 start-page: 963 year: 2012 ident: ref_62 article-title: Severe fever with thrombocytopenia syndrome virus, Shandong Province, China publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1806.111345 – ident: ref_84 – volume: 3 start-page: 409 year: 1987 ident: ref_79 article-title: Punta Toro virus infection of C57BL/6J mice: A model for phlebovirus-induced disease publication-title: Microb. Pathog. doi: 10.1016/0882-4010(87)90011-8 – volume: 22 start-page: 2070 year: 2016 ident: ref_12 article-title: Vertebrate Host Susceptibility to Heartland Virus publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2212.160472 – volume: 53 start-page: 607 year: 2016 ident: ref_47 article-title: Surveillance for Heartland Virus (Bunyaviridae: Phlebovirus) in Missouri During 2013: First Detection of Virus in Adults of Amblyomma americanum (Acari: Ixodidae) publication-title: J. Med. Entomol. doi: 10.1093/jme/tjw028 – ident: ref_27 doi: 10.1371/journal.pntd.0001623 – volume: 93 start-page: 875 year: 2015 ident: ref_35 article-title: Modeling the Present and Future Geographic Distribution of the Lone Star Tick, Amblyomma americanum (Ixodida: Ixodidae), in the Continental United States publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.15-0330 – volume: 93 start-page: 1338 year: 2015 ident: ref_13 article-title: Development and Characterization of Monoclonal Antibodies Directed Against the Nucleoprotein of Heartland Virus publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.15-0473 – volume: 121 start-page: 29 year: 2007 ident: ref_15 article-title: Cloning and expression of Rift Valley fever virus nucleocapsid (N) protein and evaluation of a N-protein based indirect ELISA for the detection of specific IgG and IgM antibodies in domestic ruminants publication-title: Vet. Microbiol. doi: 10.1016/j.vetmic.2006.11.008 – volume: 365 start-page: 410 year: 2007 ident: ref_54 article-title: Tick-borne flavivirus infection in Ixodes scapularis larvae: Development of a novel method for synchronous viral infection of ticks publication-title: Virology doi: 10.1016/j.virol.2007.03.057 – volume: 7 start-page: 45 year: 2018 ident: ref_83 article-title: Identification of tick-borne pathogen diversity by metagenomic analysis in Haemaphysalis longicornis from Xinyang, China publication-title: Infect. Dis. Poverty doi: 10.1186/s40249-018-0417-4 – volume: 95 start-page: e4476 year: 2016 ident: ref_40 article-title: Hemophagocytic lymphohistiocytosis associated with SFTS virus infection: A case report with literature review publication-title: Medicine doi: 10.1097/MD.0000000000004476 – ident: ref_45 doi: 10.1016/S1473-3099(18)30293-7 – volume: 44 start-page: 732 year: 2007 ident: ref_55 article-title: Life cycles of seven ixodid tick species (Acari: Ixodidae) under standardized laboratory conditions publication-title: J. Med. Entomol. doi: 10.1093/jmedent/44.5.732 – volume: 30 start-page: 6225 year: 2012 ident: ref_22 article-title: Healthy individuals’ immune response to the Bulgarian Crimean-Congo hemorrhagic fever virus vaccine publication-title: Vaccine doi: 10.1016/j.vaccine.2012.08.003 – volume: 53 start-page: 1226 year: 2016 ident: ref_50 article-title: Transmission of Heartland Virus (Bunyaviridae: Phlebovirus) by Experimentally Infected Amblyomma americanum (Acari: Ixodidae) publication-title: J. Med. Entomol. doi: 10.1093/jme/tjw080 – volume: 207 start-page: 1909 year: 2013 ident: ref_23 article-title: Lethal Crimean-Congo hemorrhagic fever virus infection in interferon alpha/beta receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy publication-title: J. Infect. Dis. doi: 10.1093/infdis/jit061 – volume: 207 start-page: 736 year: 2013 ident: ref_33 article-title: Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood publication-title: J. Infect. Dis. doi: 10.1093/infdis/jis748 – volume: 59 start-page: 845 year: 2014 ident: ref_39 article-title: Heartland virus-associated death in Tennessee publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciu434 – volume: 70 start-page: 1895 year: 1989 ident: ref_82 article-title: Enhancement of virus transmission by tick salivary glands publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-70-7-1895 – volume: 28 start-page: 252 year: 2012 ident: ref_52 article-title: Isolation, identification and characterization of SFTS bunyavirus from ticks collected on the surface of domestic animals publication-title: Bing Du Xue Bao – volume: 54 start-page: 249 year: 2012 ident: ref_34 article-title: Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact publication-title: Clin. Infect. Dis. doi: 10.1093/cid/cir776 – volume: 93 start-page: 1288 year: 2012 ident: ref_72 article-title: Infection and pathogenesis of Huaiyangshan virus (a novel tick-borne bunyavirus) in laboratory rodents publication-title: J. Gen. Virol. doi: 10.1099/vir.0.041053-0 – volume: 88 start-page: 1781 year: 2014 ident: ref_74 article-title: The pathogenesis of Severe Fever with Thrombocytopenia Syndrome virus infection in alpha/beta interferon knockout mice: Insights into the pathologic mechanisms of a new viral hemorrhagic fever publication-title: J. Virol. doi: 10.1128/JVI.02277-13 – ident: ref_7 doi: 10.1371/journal.pone.0062083 – ident: ref_68 doi: 10.1371/journal.pntd.0004092 – volume: 88 start-page: 510 year: 2013 ident: ref_63 article-title: Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan County, Shandong Province, China publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.11-0760 – volume: 127 start-page: 21 year: 2008 ident: ref_17 article-title: Recombinant nucleocapsid-based ELISA for detection of IgG antibody to Rift Valley fever virus in African buffalo publication-title: Vet. Microbiol. doi: 10.1016/j.vetmic.2007.07.031 – volume: 49 start-page: 83 year: 1996 ident: ref_19 article-title: Immunoblot detection of antibodies to Toscana virus publication-title: J. Med. Virol. doi: 10.1002/(SICI)1096-9071(199606)49:2<83::AID-JMV2>3.0.CO;2-F – volume: 48 start-page: 307 year: 2003 ident: ref_36 article-title: The ascendancy of Amblyomma americanum as a vector of pathogens affecting humans in the United States publication-title: Annu. Rev. Entomol. doi: 10.1146/annurev.ento.48.091801.112728 – ident: ref_65 doi: 10.1371/journal.pntd.0003267 – volume: 8 start-page: 9 year: 2017 ident: ref_66 article-title: Molecular detection of severe fever with thrombocytopenia syndrome virus (SFTSV) in feral cats from Seoul, Korea publication-title: Ticks Tick-Borne Dis. doi: 10.1016/j.ttbdis.2016.08.005 – volume: 7 start-page: 193 year: 1993 ident: ref_81 article-title: Enhancement of tick-borne encephalitis virus transmission by tick salivary gland extracts publication-title: Med. Vet. Entomol. doi: 10.1111/j.1365-2915.1993.tb00674.x – volume: 2 start-page: 275 year: 2010 ident: ref_14 article-title: Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization publication-title: MAbs doi: 10.4161/mabs.2.3.11676 – volume: 206 start-page: 1095 year: 2012 ident: ref_32 article-title: Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients publication-title: J. Infect. Dis. doi: 10.1093/infdis/jis472 – ident: ref_30 – volume: 38 start-page: 760 year: 2017 ident: ref_31 article-title: Occupational Severe Fever With Thrombocytopenia Syndrome Following Needle-Stick Injury publication-title: Infect. Control. Hosp. Epidemiol. doi: 10.1017/ice.2017.61 – volume: 89 start-page: 7852 year: 2015 ident: ref_80 article-title: Tick saliva enhances Powassan virus transmission to the host, influencing its dissemination and the course of disease publication-title: J. Virol. doi: 10.1128/JVI.01056-15 – volume: 364 start-page: 1523 year: 2011 ident: ref_2 article-title: Fever with thrombocytopenia associated with a novel bunyavirus in China publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1010095 – volume: 90 start-page: 256 year: 2014 ident: ref_51 article-title: Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011 publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.13-0423 – ident: ref_42 doi: 10.1371/journal.ppat.1002369 – volume: 86 start-page: 109 year: 1985 ident: ref_57 article-title: Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal Hantaan virus infection publication-title: Arch. Virol. doi: 10.1007/BF01314117 – volume: 211 start-page: 915 year: 2015 ident: ref_77 article-title: SFTS virus infection in nonhuman primates publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiu564 – volume: 127 start-page: 10 year: 2005 ident: ref_16 article-title: An inhibition enzyme-linked immunosorbent assay for the detection of antibody to Rift Valley fever virus in humans, domestic and wild ruminants publication-title: J. Virol. Methods doi: 10.1016/j.jviromet.2005.02.008 – ident: ref_4 doi: 10.1371/journal.pntd.0005264 – volume: 35 start-page: 202 year: 1962 ident: ref_61 article-title: Results of a tick-host study in northwest Arkansas publication-title: J. Kans. Entomol. Soc. – volume: 162 start-page: 2505 year: 2017 ident: ref_5 article-title: Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017) publication-title: Arch. Virol. doi: 10.1007/s00705-017-3358-5 – volume: 57 start-page: 1292 year: 2013 ident: ref_44 article-title: Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome publication-title: Clin. Infect. Dis. doi: 10.1093/cid/cit530 – volume: 98 start-page: 1194 year: 2018 ident: ref_69 article-title: Experimental Infection of White-Tailed Deer (Odocoileus virginanus) with Heartland Virus publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.17-0963 – volume: 6 start-page: 55 year: 1999 ident: ref_18 article-title: Humoral response in Toscana virus acute neurologic disease investigated by viral-protein-specific immunoassays publication-title: Clin. Diagn. Lab. Immunol. doi: 10.1128/CDLI.6.1.55-60.1999 – volume: 91 start-page: e01942-16 year: 2017 ident: ref_76 article-title: Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir publication-title: J. Virol. doi: 10.1128/JVI.01942-16 – volume: 98 start-page: 664 year: 2001 ident: ref_24 article-title: Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.98.2.664 – volume: 109 start-page: 10053 year: 2012 ident: ref_71 article-title: Pathogenesis of emerging Severe Fever with Thrombocytopenia Syndrome virus in C57/BL6 mouse model publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1120246109 – volume: 511 start-page: 175 year: 2017 ident: ref_75 article-title: Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir publication-title: Virology doi: 10.1016/j.virol.2017.08.004 – volume: 21 start-page: 1830 year: 2015 ident: ref_59 article-title: Heartland virus neutralizing antibodies in vertebrate wildlife, United States, 2009–2014 publication-title: Emerg. Infect. Dis doi: 10.3201/eid2110.150380 – volume: 24 start-page: 893 year: 2018 ident: ref_37 article-title: Heartland Virus and Hemophagocytic Lymphohistiocytosis in Immunocompromised Patient, Missouri, USA publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2405.171802 – volume: 94 start-page: 35 year: 2016 ident: ref_67 article-title: Expanding Range of Amblyomma americanum and Simultaneous Changes in the Epidemiology of Spotted Fever Group Rickettsiosis in the United States publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.15-0580 – volume: 97 start-page: 317 year: 1986 ident: ref_20 article-title: Comparison of techniques for demonstrating antibodies to Rift Valley fever virus publication-title: J. Hyg. (Lond.) doi: 10.1017/S0022172400065414 – ident: ref_29 – volume: 237 start-page: 775 year: 1987 ident: ref_56 article-title: A novel mode of arbovirus transmission involving a nonviremic host publication-title: Science doi: 10.1126/science.3616608 – volume: 16 start-page: 433 year: 2010 ident: ref_53 article-title: Blood meal analysis to identify reservoir hosts for Amblyomma americanum ticks publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1603.090911 – volume: 8 start-page: 104 year: 2017 ident: ref_70 article-title: Animal Models of Emerging Tick-Borne Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection publication-title: Front. Microbiol. doi: 10.3389/fmicb.2017.00104 – volume: 64 start-page: 510 year: 2017 ident: ref_38 article-title: Novel Clinical and Pathologic Findings in a Heartland Virus-Associated Death publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciw766 – ident: ref_3 doi: 10.1371/journal.pone.0165207 – ident: ref_64 – volume: 395 start-page: 143 year: 2009 ident: ref_78 article-title: Punta Toro virus (Bunyaviridae, Phlebovirus) infection in mice: Strain differences in pathogenesis and host interferon response publication-title: Virology doi: 10.1016/j.virol.2009.09.003 – volume: 14 start-page: 763 year: 2014 ident: ref_43 article-title: Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(14)70718-2 – volume: 79 start-page: 5606 year: 2005 ident: ref_25 article-title: Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system publication-title: J. Virol. doi: 10.1128/JVI.79.9.5606-5615.2005 – volume: 92 start-page: 2467 year: 2011 ident: ref_6 article-title: Recent advances in the molecular and cellular biology of bunyaviruses publication-title: J. Gen. Virol. doi: 10.1099/vir.0.035105-0 – volume: 55 start-page: 701 year: 2018 ident: ref_48 article-title: Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015 publication-title: J. Med. Entomol. doi: 10.1093/jme/tjx251 – volume: 89 start-page: 594 year: 2015 ident: ref_8 article-title: Comprehensive molecular detection of tick-borne phleboviruses leads to the retrospective identification of taxonomically unassigned bunyaviruses and the discovery of a novel member of the genus Phlebovirus publication-title: J. Virol. doi: 10.1128/JVI.02704-14 – volume: 20 start-page: 1426 year: 2013 ident: ref_21 article-title: Human antibody neutralizes Severe Fever with Thrombocytopenia Syndrome virus, an emerging hemorrhagic fever virus publication-title: Clin. Vaccine Immunol. doi: 10.1128/CVI.00222-13 – volume: 86 start-page: 8388 year: 2012 ident: ref_73 article-title: Suppression of the Interferon and NF-kappaB Responses by Severe Fever with Thrombocytopenia Syndrome Virus publication-title: J. Virol. doi: 10.1128/JVI.00612-12 – volume: 367 start-page: 834 year: 2012 ident: ref_1 article-title: A new phlebovirus associated with severe febrile illness in Missouri publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1203378 – volume: 19 start-page: 1487 year: 2013 ident: ref_60 article-title: Novel Bunyavirus in Domestic and Captive Farmed Animals, Minnesota, USA publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1908.130165 – volume: 63 start-page: 270 year: 2014 ident: ref_28 article-title: Prevention, Notes from the field: Heartland virus disease—United States, 2012–2013 publication-title: Morb. Mortal. Wkly. Rep. – volume: 20 start-page: 1040 year: 2014 ident: ref_11 article-title: Novel phlebovirus with zoonotic potential isolated from ticks, Australia publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2006.140003 – volume: 21 start-page: 1770 year: 2015 ident: ref_49 article-title: Haemaphysalis longicornis Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2110.150126 – volume: 89 start-page: 445 year: 2013 ident: ref_46 article-title: First detection of Heartland virus (Bunyaviridae: Phlebovirus) from field collected arthropods publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.13-0209 – reference: 15893560 - J Virol Methods. 2005 Jul;127(1):10-8 – reference: 26503274 - Am J Trop Med Hyg. 2015 Dec;93(6):1338-40 – reference: 29730989 - Infect Dis Poverty. 2018 May 7;7(1):45 – reference: 22095565 - Clin Infect Dis. 2012 Jan 15;54(2):249-52 – reference: 29365128 - J Med Entomol. 2018 May 4;55(3):701-705 – reference: 22545170 - PLoS Negl Trop Dis. 2012;6(4):e1623 – reference: 22764528 - Bing Du Xue Bao. 2012 May;28(3):252-7 – reference: 20400862 - MAbs. 2010 May-Jun;2(3):275-84 – reference: 27542506 - Ticks Tick Borne Dis. 2017 Jan;8(1):9-12 – reference: 24837566 - Lancet Infect Dis. 2014 Aug;14(8):763-772 – reference: 11209062 - Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):664-9 – reference: 22931317 - N Engl J Med. 2012 Aug 30;367(9):834-41 – reference: 17490700 - Virology. 2007 Sep 1;365(2):410-8 – reference: 26401988 - Emerg Infect Dis. 2015 Oct;21(10):1830-3 – reference: 29664369 - Emerg Infect Dis. 2018 May;24(5):893-897 – reference: 27927857 - Clin Infect Dis. 2017 Feb 15;64(4):510-512 – reference: 26503270 - Am J Trop Med Hyg. 2016 Jan;94(1):35-42 – reference: 30054190 - Lancet Infect Dis. 2018 Oct;18(10):1127-1137 – reference: 27495089 - Medicine (Baltimore). 2016 Aug;95(31):e4476 – reference: 26583599 - Emerg Infect Dis. 2015 Dec;21(12):2246-8 – reference: 22608264 - Emerg Infect Dis. 2012 Jun;18(6):963-5 – reference: 23863504 - Clin Vaccine Immunol. 2013 Sep;20(9):1426-32 – reference: 12414740 - Annu Rev Entomol. 2003;48:307-37 – reference: 26908283 - J Clin Pathol. 2016 Jun;69(6):537-41 – reference: 22850122 - J Infect Dis. 2012 Oct 1;206(7):1095-102 – reference: 25870419 - Am J Trop Med Hyg. 2015 Jun;92(6):1163-7 – reference: 17884306 - Vet Microbiol. 2008 Feb 5;127(1-2):21-8 – reference: 23878186 - Am J Trop Med Hyg. 2013 Sep;89(3):445-52 – reference: 17915502 - J Med Entomol. 2007 Sep;44(5):732-40 – reference: 2462155 - Microb Pathog. 1987 Dec;3(6):409-22 – reference: 24856477 - Emerg Infect Dis. 2014 Jun;20(6):1040-3 – reference: 23966016 - Emerg Infect Dis. 2013;19(9):1487-9 – reference: 23339197 - Am J Trop Med Hyg. 2013 Mar;88(3):510-2 – reference: 22902680 - Vaccine. 2012 Sep 28;30(44):6225-9 – reference: 26217042 - Am J Trop Med Hyg. 2015 Oct;93(4):875-90 – reference: 26485390 - PLoS Negl Trop Dis. 2015 Oct 20;9(10):e0004092 – reference: 23637969 - PLoS One. 2013 Apr 29;8(4):e62083 – reference: 24917656 - Clin Infect Dis. 2014 Sep 15;59(6):845-50 – reference: 22665769 - Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10053-8 – reference: 3537118 - J Hyg (Lond). 1986 Oct;97(2):317-29 – reference: 28033338 - PLoS Negl Trop Dis. 2016 Dec 29;10(12):e0005264 – reference: 22623799 - J Virol. 2012 Aug;86(16):8388-401 – reference: 3616608 - Science. 1987 Aug 14;237(4816):775-7 – reference: 2864037 - Arch Virol. 1985;86(1-2):109-20 – reference: 28194148 - Front Microbiol. 2017 Jan 30;8:104 – reference: 19783024 - Virology. 2009 Dec 5;395(1):143-51 – reference: 26402039 - Emerg Infect Dis. 2015 Oct;21(10):1770-6 – reference: 24343883 - Am J Trop Med Hyg. 2014 Feb;90(2):256-9 – reference: 23965284 - Clin Infect Dis. 2013 Nov;57(9):1292-9 – reference: 20202418 - Emerg Infect Dis. 2010 Mar;16(3):433-40 – reference: 27776187 - PLoS One. 2016 Oct 24;11(10):e0165207 – reference: 8991940 - J Med Virol. 1996 Jun;49(2):83-6 – reference: 23225899 - J Infect Dis. 2013 Mar 1;207(5):736-9 – reference: 24670929 - MMWR Morb Mortal Wkly Rep. 2014 Mar 28;63(12):270-1 – reference: 21865443 - J Gen Virol. 2011 Nov;92(Pt 11):2467-84 – reference: 23417661 - J Infect Dis. 2013 Jun 15;207(12):1909-21 – reference: 2544668 - J Gen Virol. 1989 Jul;70 ( Pt 7):1895-8 – reference: 22357748 - J Gen Virol. 2012 Jun;93(Pt 6):1288-93 – reference: 27032416 - J Med Entomol. 2016 May;53(3):607-612 – reference: 27869591 - Emerg Infect Dis. 2016 Dec;22(12):2070-2077 – reference: 28397631 - Infect Control Hosp Epidemiol. 2017 Jun;38(6):760-762 – reference: 25330383 - PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3267 – reference: 28434098 - Arch Virol. 2017 Aug;162(8):2505-2538 – reference: 27881648 - J Virol. 2017 Jan 18;91(3): – reference: 11152510 - J Virol. 2001 Feb;75(3):1371-7 – reference: 29488458 - Am J Trop Med Hyg. 2018 Apr;98(4):1194-1196 – reference: 17187944 - Vet Microbiol. 2007 Mar 31;121(1-2):29-38 – reference: 25339769 - J Virol. 2015 Jan;89(1):594-604 – reference: 27330103 - J Med Entomol. 2016 Jun 20;:null – reference: 28865344 - Virology. 2017 Nov;511:175-183 – reference: 24390329 - J Virol. 2014 Mar;88(6):3605-9 – reference: 22114553 - PLoS Pathog. 2011 Nov;7(11):e1002369 – reference: 8481537 - Med Vet Entomol. 1993 Apr;7(2):193-6 – reference: 25326554 - J Infect Dis. 2015 Mar 15;211(6):915-25 – reference: 24257618 - J Virol. 2014 Feb;88(3):1781-6 – reference: 21410387 - N Engl J Med. 2011 Apr 21;364(16):1523-32 – reference: 15827175 - J Virol. 2005 May;79(9):5606-15 – reference: 9874664 - Clin Diagn Lab Immunol. 1999 Jan;6(1):55-60 – reference: 25995246 - J Virol. 2015 Aug;89(15):7852-60 |
| SSID | ssj0066907 |
| Score | 2.466151 |
| SecondaryResourceType | review_article |
| Snippet | First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in 2009, Heartland virus (HRTV) is genetically closely related to... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 498 |
| SubjectTerms | Amblyomma americanum Animal models Arachnids Disease control Disease transmission Epidemiology Feeding Fever Genomes Heartland virus Hospitalization Illnesses Infections Larvae lone star tick Nymphs Pathogenesis Procyonidae Proteins Review RNA polymerase Thrombocytopenia transmission Viremia Virology Viruses |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9tAEB5KoNBL6Dtq3aKWHnKIiKzZh3TsI67pofTQhNyE9kUDQQ62XPC_74xWVu1g6KVX7Rx2Z2Z3v281fAPwAYXBUOhp1uSUwXTglZkhnpHZonBVLnwTotrndzW_FN-u5fVOqy-uCYvywNFx59Y0NnhmCcRFCu1LxMaUQWpTOInC8elLd96WTMUzWDHnizpCSKT-_PeUoARh4XLv9ulF-g8hy_sFkjs3zuwxHA9QMf0Yp_gEHvj2KTyMzSM3z-DrnJK048LE9OpmuV6lF3-bvW7O0qv-OT7dcf9ZyrZf4h-Z9Mei40Kh5vY5XM4ufn6eZ0NbhMxKlB3ldaUtq-J4RWAMVRlQVKiMKhWxEeedsEEUjpCRCi5gCKhp7dr6kFfeS4Mv4KhdtP4E0tJ4ipPNq6bvQS0rK7xx2snCIGoXEjjduqu2g2Y4t664rYk7sGfr0bMJvB9N76JQxiGjT-zz0YC1rfsPFPF6iHj9r4gnMNlGrB423KrmG5jXn4sE3o3DtFX4_0fT-sWabfj5RhJATuBlDPA4EyQsgwTOEtB7od-b6v5Ie_Orl-NWxDjLQrz6H2t7DY8IkfUFKVMxgaNuufZvCPV05m2f4H8AjHT_tQ priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9xADLYoqFIviD4J0CqteuiBiN14HskJQQtd9VD1UNDeoswLkFACu1kk_j12kg1shXrN-DCxPZ7PHuszwFcUBkOqx0k5Ig-mgJclhvKMxKapy0fCl6Fj-_ytJmfi11RO-4LbvG-rXMbENlC72nKN_IBDbKboehaHN7cJT43i19V-hMYL2GDqMm7p0tMh4VKc-XVsQkip_cHdmAAFIeJs5Q5qqfqfw5f_tkk-uXdOt2CzB4zxUWfh17Dmqzfwshshef8Wfk7IVRtuT4zPr2aLeXzyOPL1fj8-b4vy8RMj7Mcs-6N7l4n_1A23C5XX7-Ds9OTv90nSD0dIrETZkHfn2jI3jlcEyVBlAUWOyihWknLeCRtE6ggfqeAChoCa_l1bH0a599Lge1iv6spvQ5wZT9ayo7xsJ1HL3ApvnHYyNYjahQi-LdVV2J45nAdYXBeUQbBmi0GzEXwZRG86uoznhI5Z54MAM1y3H-rZRdEfmMKa0gbP2SHloKn2GWJpsiC1SZ1E4SLYW1qs6I_dvHh0kgg-D8t0YPgVpKx8vWAZLuJIgskRfOgMPOwECdEgQbQI9IrpV7a6ulJdXbak3IryziwVO__f1i68IsTVNpyMxR6sN7OF_0iopjGfWtd9AF_i9pw priority: 102 providerName: ProQuest |
| Title | Heartland Virus Epidemiology, Vector Association, and Disease Potential |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30223439 https://www.proquest.com/docview/2123866004 https://www.proquest.com/docview/2109335020 https://pubmed.ncbi.nlm.nih.gov/PMC6164824 https://doaj.org/article/cbacfe924918427e833ab8f57b2d534d |
| Volume | 10 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEB71ISQuiHddSmQQBw412N6XfUCIQtoIiapCpMrN8r6gUuTQ1EHk3zNjO6ZGOXDxwTuWdufh-b7d1QzAK8Y186lKojJGD8YfXhZp5BmRSVObx9yVvq32eS4nU_55JmY7sOmx2SnwZiu1o35S0-X8ze_r9XsM-HfEOJGyv_2VIFBApJvtwj4mJEXx-YX3hwmSCGBzuJxTQ7VEtAWGhp8O0lJTvX8b5Pz35uStVHR6H-51GDL80Br9Aey46iHcabtKrh_B2QS9t6Ybi-Hl1XJ1E47_doFdH4eXzT59eMsuxyHJfmqPasKLRU03iMr5Y5iejr99nERdv4TICCZqdPhcGSqX4ySiNCYzz3jOpJaZRJpineXG89QiZJLeeuY9U7h2ZZyPc-eEZk9gr1pU7gDCTDs0oInzsmlOLXLDnbbKilQzpqwP4PVGXYXpiolTT4t5gaSCNFv0mg3gZS_6s62gsU3ohHTeC1DR6-bFYvm96GKoMLo03hFhRFqaKpcxVurMC6VTKxi3ARxtLFZsHKmg1Ezrj3kAL_phjCE6GCkrt1iRDO3rCETOATxtDdzPhCHIYYjaAlAD0w-mOhyprn40dbolUtEs5Yf_o4BncBehWHMTJeFHsFcvV-45wp1aj2BXzdQI9k_G5xdfR82mAT7PZsmocfM_fuD_5g |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9RAEJ_gEaMvxm-rqNVo4gMNvd3ttn0wRuTwELwQA4S30v1SEtLiXU9z_5R_ozP9gjPEN167k81kvvY3u9MZgDdcKO5YPAzyEC0YA14SKMwzAs2YSUNhc9d0-5zI8aH4chwdr8Cf7l8YKqvsYmIdqE2p6Y58g0JsIvF4Fh_OfwY0NYpeV7sRGo1Z7NrFb0zZZu93tlC_bxnbHh18GgftVIFARzyq0CzSWFNTGSsRy3CZOC5SLpWk3aWxRmgnmEFgIZ1x3DkeI9Oxti5MrY0Ux31vwKrgmMoMYHVzNNn_1sV-Sblm07-I8zTc-DVECIMYPFk69erhAFch2n8LMy-ddNt34U4LUf2PjU3dgxVb3IebzdDKxQP4PEYpVFQQ6R-dTuczf3QxZHax7h_VzwD-JbWv-0S71bwE-ftlRQVK-dlDOLwWwT2CQVEW9gn4ibJoHzpM83r2dZRqYZWJTcQU57FxHrzrxJXptlc5jcw4yzBnIclmvWQ9eN2TnjcNOq4i2iSZ9wTUU7v-UE6_Z62LZlrl2lnKRzHrZbFNOM9V4qJYMRNxYTxY6zSWtY4-yy7M0oNX_TK6KL275IUt50RD10YRAnMPHjcK7jnhiKE4gkIP4iXVL7G6vFKc_qjbgEvMdBMmnv6frZdwa3zwdS_b25nsPoPbiPfqcpehWINBNZ3b54ipKvWiNWQfTq7bd_4CV6kz3A |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9NQEB6VIhAXxI6hgEEgcagVx2-zDwgBaUgpqnqgVW6u3waVqrgkDih_jV_HjLc2qOLWqz2yn2d737wZzwC8Zlwzn6hhVMSowejw0khjnBGZJLFZzF3hm26f-3JyyL9MxXQD_nT_wlBZZecTa0dtS0Nn5ANysanE7ZkPfFsWcTAavz_7GdEEKcq0duM0GhXZc6vfGL4t3u2OUNZvkmS88-3TJGonDERGMFGhimTKUIMZJxHXMJl6xjMmtaQ3SessN54nFkGG9NYz75nCD1DG-ThzTmiGz70G1xUTQ7IxNe2DPUlRZ9PJiLEsHvwaIphBNJ6u7X_1mIDLsO2_JZoX9rzxHbjdgtXwQ6Ndd2HDze7BjWZ85eo-fJ4gDyoqjQyPTubLRbhzPm52tR0e1QmB8IICbIdEO2pyQuFBWVGpUnH6AA6vhG0PYXNWztxjCFPtUFNMnBX1FGyRGe60VVYkmjFlfQBvO3blpu1aTsMzTnOMXoizec_ZAF71pGdNq47LiD4Sz3sC6q5dXyjn3_PWWHOjC-MdRaYY_ybKpYwVOvVC6cQKxm0AW53E8tbkF_m5ggbwsr-NxkoZmGLmyiXR0AGSQIgewKNGwP1KGKIphvAwALUm-rWlrt-ZnfyoG4JLjHnThD_5_7JewE20mPzr7v7eU7iFwK-uexnyLdis5kv3DMFVpZ_XWhzC8VWbzV9JSTas |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heartland+Virus+Epidemiology%2C+Vector+Association%2C+and+Disease+Potential&rft.jtitle=Viruses&rft.au=Brault%2C+Aaron+C.&rft.au=Savage%2C+Harry+M.&rft.au=Duggal%2C+Nisha+K.&rft.au=Eisen%2C+Rebecca+J.&rft.date=2018-09-14&rft.issn=1999-4915&rft.eissn=1999-4915&rft.volume=10&rft.issue=9&rft.spage=498&rft_id=info:doi/10.3390%2Fv10090498&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_v10090498 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1999-4915&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1999-4915&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1999-4915&client=summon |