Induction of protective immune responses at respiratory mucosal sites

• Published in: Human vaccines & immunotherapeutics Vol. 20; no. 1; p. 2368288
• Main Authors: Park, Seok-Chan, Wiest, Matthew J., Yan, Vivian, Wong, Pamela T., Schotsaert, Michael
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2024; Taylor & Francis Group
• Subjects: adjuvant; Adjuvants, Immunologic - administration & dosage; Adjuvants, Vaccine; Administration, Mucosal; Animals; Humans; Immunity, Mucosal; Immunoglobulin A, Secretory - immunology; Immunology; Memory T Cells - immunology; Mucosal; Respiratory Mucosa - immunology; respiratory tract; Respiratory Tract Infections - immunology; Respiratory Tract Infections - prevention & control; Review; Vaccination - methods; vaccine; Vaccines - administration & dosage; Vaccines - immunology; vaccinology; virus; vaccine; Mucosal; adjuvant; virus; respiratory tract; vaccinology

Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal site...