Induction of protective immune responses at respiratory mucosal sites

Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal site...

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Published inHuman vaccines & immunotherapeutics Vol. 20; no. 1; p. 2368288
Main Authors Park, Seok-Chan, Wiest, Matthew J., Yan, Vivian, Wong, Pamela T., Schotsaert, Michael
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 31.12.2024
Taylor & Francis Group
Subjects
adjuvant
Adjuvants, Immunologic - administration & dosage
Adjuvants, Vaccine
Administration, Mucosal
Animals
Humans
Immunity, Mucosal
Immunoglobulin A, Secretory - immunology
Immunology
Memory T Cells - immunology
Mucosal
Respiratory Mucosa - immunology
respiratory tract
Respiratory Tract Infections - immunology
Respiratory Tract Infections - prevention & control
Review
Vaccination - methods
vaccine
Vaccines - administration & dosage
Vaccines - immunology
vaccinology
virus
vaccine
Mucosal
adjuvant
virus
respiratory tract
vaccinology
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Abstract Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal sites. This manuscript delves into some of the latest developments in mucosal vaccination, particularly focusing on advancements in adjuvant technologies and the role of these adjuvants in enhancing vaccine efficacy against respiratory pathogens. It highlights the anatomical and immunological complexities of the respiratory mucosal immune system, emphasizing the significance of mucosal secretory IgA and tissue-resident memory T cells in local immune responses. We further discuss the differences between immune responses induced through traditional parenteral vaccination approaches vs. mucosal administration strategies, and explore the protective advantages offered by immunization through mucosal routes.
AbstractList Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal sites. This manuscript delves into some of the latest developments in mucosal vaccination, particularly focusing on advancements in adjuvant technologies and the role of these adjuvants in enhancing vaccine efficacy against respiratory pathogens. It highlights the anatomical and immunological complexities of the respiratory mucosal immune system, emphasizing the significance of mucosal secretory IgA and tissue-resident memory T cells in local immune responses. We further discuss the differences between immune responses induced through traditional parenteral vaccination approaches vs. mucosal administration strategies, and explore the protective advantages offered by immunization through mucosal routes.
Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal sites. This manuscript delves into some of the latest developments in mucosal vaccination, particularly focusing on advancements in adjuvant technologies and the role of these adjuvants in enhancing vaccine efficacy against respiratory pathogens. It highlights the anatomical and immunological complexities of the respiratory mucosal immune system, emphasizing the significance of mucosal secretory IgA and tissue-resident memory T cells in local immune responses. We further discuss the differences between immune responses induced through traditional parenteral vaccination approaches vs. mucosal administration strategies, and explore the protective advantages offered by immunization through mucosal routes.Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal sites. This manuscript delves into some of the latest developments in mucosal vaccination, particularly focusing on advancements in adjuvant technologies and the role of these adjuvants in enhancing vaccine efficacy against respiratory pathogens. It highlights the anatomical and immunological complexities of the respiratory mucosal immune system, emphasizing the significance of mucosal secretory IgA and tissue-resident memory T cells in local immune responses. We further discuss the differences between immune responses induced through traditional parenteral vaccination approaches vs. mucosal administration strategies, and explore the protective advantages offered by immunization through mucosal routes.
Author Park, Seok-Chan
Wiest, Matthew J.
Schotsaert, Michael
Yan, Vivian
Wong, Pamela T.
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Issue 1
Keywords vaccine
Mucosal
adjuvant
virus
respiratory tract
vaccinology
Language English
License open-access: http://creativecommons.org/licenses/by-nc/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
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Snippet Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an...
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SubjectTerms adjuvant
Adjuvants, Immunologic - administration & dosage
Adjuvants, Vaccine
Administration, Mucosal
Animals
Humans
Immunity, Mucosal
Immunoglobulin A, Secretory - immunology
Immunology
Memory T Cells - immunology
Mucosal
Respiratory Mucosa - immunology
respiratory tract
Respiratory Tract Infections - immunology
Respiratory Tract Infections - prevention & control
Review
Vaccination - methods
vaccine
Vaccines - administration & dosage
Vaccines - immunology
vaccinology
virus
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Title Induction of protective immune responses at respiratory mucosal sites
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