SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells - Zhang, Linda; Hsu, Joanne I; Braekeleer, Etienne D; Chen, Chun-Wei; Patel, Tajhal D; Martell, Alejandra G; Guzman, Anna G; Wohlan, Katharina; Waldvogel, Sarah M; Uryu, Hidetaka; Tovy, Ayala; Callen, Elsa; et al. (eLife, 2024)
Keywords: Apoptosis; Cancer; Cancer Biology; Cell Biology; Cell cycle; Cell Line, Tumor; Cloning; CRISPR; CRISPR-Cas Systems; DNA damage; Genes; Genomes; Humans; Leukemia; Leukemia - genetics; Leukemia research; Magnesium; Medical prognosis; Mutants; Mutation; Ovaries; Oxidative Stress; Phosphatase; Phosphatases; Physiological aspects; Protein phosphatase; Protein Phosphatase 2C - genetics; Protein Phosphatase 2C - metabolism; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Superoxide dismutase; Superoxide Dismutase-1 - genetics; Superoxide Dismutase-1 - metabolism; Synthetic Lethal Mutations; United States; leukemia; mouse; cancer; cancer biology; cell biology; DNA damage