The HPA axis in bipolar disorder: Systematic review and meta-analysis

• Published in: Psychoneuroendocrinology Vol. 63; pp. 327 - 342
• Main Authors: Belvederi Murri, Martino, Prestia, Davide, Mondelli, Valeria, Pariante, Carmine, Patti, Sara, Olivieri, Benedetta, Arzani, Costanza, Masotti, Mattia, Respino, Matteo, Antonioli, Marco, Vassallo, Linda, Serafini, Gianluca, Perna, Giampaolo, Pompili, Maurizio, Amore, Mario
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2016
• Subjects: Adrenocorticotropic Hormone - metabolism; Bipolar disorder; Bipolar Disorder - metabolism; Bipolar Disorder - physiopathology; Case-Control Studies; Corticotropin-Releasing Hormone - metabolism; Cortisol; Depression; Endocrinology & Metabolism; Glucocorticoid receptor; HPA Axis; Humans; Hydrocortisone - metabolism; Hypothalamo-Hypophyseal System - metabolism; Hypothalamo-Hypophyseal System - physiopathology; Mania; Pituitary-Adrenal System - metabolism; Pituitary-Adrenal System - physiopathology; Psychiatry; Mania; Bipolar disorder; Depression; Cortisol; HPA Axis; Glucocorticoid receptor

•Bipolar disorder is associated with state and trait hyperactivity of the HPA axis.•Abnormalities of glucocorticoid signaling are found in several key brain areas.•Cortisol levels are associated with structural and functional neuroimaging indices in BD.•HPA axis dysregulation is not a endophenotype...