Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis

• Published in: The Lancet (British edition) Vol. 385; no. 9982; pp. 2047 - 2056
• Main Authors: Palmer, Suetonia C, Mavridis, Dimitris, Navarese, Eliano, Craig, Jonathan C, Tonelli, Marcello, Salanti, Georgia, Wiebe, Natasha, Ruospo, Marinella, Wheeler, David C, Strippoli, Giovanni F M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 23.05.2015; Elsevier Limited
• Subjects: ACE inhibitors; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - therapeutic use; Blood pressure; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - mortality; Diabetes Mellitus, Type 1 - prevention & control; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - mortality; Diabetes Mellitus, Type 2 - prevention & control; Diabetic Angiopathies - complications; Diabetic Angiopathies - drug therapy; Diabetic Nephropathies - complications; Diabetic Nephropathies - mortality; Diabetic Nephropathies - prevention & control; Diuretics; Heart attacks; Humans; Hypertension; Hypertension - complications; Hypertension - drug therapy; Hypertension - mortality; Internal Medicine; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - prevention & control; Kidneys; Medical research; Middle Aged; Mortality; Randomized Controlled Trials as Topic; Safety; Studies; Systematic review; Treatment Outcome

The comparative efficacy and safety of pharmacological agents to lower blood pressure in adults with diabetes and kidney disease remains controversial. We aimed to investigate the benefits and harms of blood pressure-lowering drugs in this population of patients. We did a network meta-analysis of ra...