Breast Cancer Resistance Protein in Drug Resistance of Primitive CD34+38− Cells in Acute Myeloid Leukemia

• Published in: Clinical cancer research Vol. 11; no. 6; pp. 2436 - 2444
• Main Authors: RAAIJMAKERS, Marc H. G. P, DE GROUW, Elke P. L. M, HEUVER, Leonie H. H, VAN DER REIJDEN, Bert A, JANSEN, Joop H, SCHEPER, Rik J, SCHEFFER, George L, DE WITTE, Theo J. M, RAYMAKERS, Reinier A. P
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.03.2005
• Subjects: Acute Disease; ADP-ribosyl Cyclase - immunology; ADP-ribosyl Cyclase - metabolism; ADP-ribosyl Cyclase 1; Adult; Aged; Antigens, CD - immunology; Antigens, CD - metabolism; Antigens, CD34 - immunology; Antigens, CD34 - metabolism; Antineoplastic agents; Antineoplastic Agents - metabolism; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - metabolism; Biological and medical sciences; Bone Marrow - immunology; Bone Marrow - metabolism; Drug Resistance; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Hematologic and hematopoietic diseases; Humans; Leukemia, Myeloid - classification; Leukemia, Myeloid - immunology; Leukemia, Myeloid - metabolism; Leukemias and lymphomas; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Membrane Glycoproteins; Middle Aged; Mitoxantrone - metabolism; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Pharmacology. Drug treatments; Stem Cell Biology; Stem Cells - cytology; Stem Cells - immunology; Stem Cells - metabolism; Tumor Cells, Cultured; Primitive; Treatment resistance; Acute; Malignant hemopathy; In vitro; Breast cancer resistance protein; Acute myelocytic leukemia

Purpose: Acute myeloid leukemia (AML) is considered a stem cell disease. Incomplete chemotherapeutic eradication of leukemic CD34+38− stem cells is likely to result in disease relapse. The purpose of this study was to investigate the role of the breast cancer resistance protein (BCRP/ATP-binding cas...