MiGut: A scalable in vitro platform for simulating the human gut microbiome—Development, validation and simulation of antibiotic‐induced dysbiosis

• Published in: Microbial biotechnology Vol. 16; no. 6; pp. 1312 - 1324
• Main Authors: Davis Birch, William A., Moura, Ines B., Ewin, Duncan J., Wilcox, Mark H., Buckley, Anthony M., Culmer, Peter R., Kapur, Nikil
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2023; John Wiley and Sons Inc; Wiley
• Subjects: Animal models; Animals; Anti-Bacterial Agents - adverse effects; Antibiotics; Bacteria - genetics; Cause-effect relationships; Colon; Complexity; Digestive system; Dysbacteriosis; Dysbiosis - chemically induced; Dysbiosis - microbiology; Gastrointestinal Microbiome; Humans; In vivo methods and tests; Intestinal microflora; Longitudinal studies; Microbiomes; Microbiota; Pathogenesis; Physiology; Potassium

In vitro models of the human colon have been used extensively in understanding the human gut microbiome (GM) and evaluating how internal and external factors affect the residing bacterial populations. Such models have been shown to be highly predictive of in vivo outcomes and have a number of advant...