Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development. Here we explore how these genes act together in mammary gland initiation. We compared expression of Tbx3, the gene associated with the human con...
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Published in | Journal of anatomy Vol. 205; no. 1; pp. 1 - 13 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Science Ltd
01.07.2004
Blackwell Science Inc |
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Abstract | Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development. Here we explore how these genes act together in mammary gland initiation. We compared expression of Tbx3, the gene associated with the human condition ulnar–mammary syndrome, expression of the gene encoding the dual‐specificity MAPK phosphatase Pyst1/MKP3, which is an early response to FGFR1 signalling (as judged by sensitivity to the SU5402 inhibitor), and expression of Lef1, encoding a transcription factor mediating Wnt signalling and the earliest gene so far known to be expressed in mammary gland development. We found that Tbx3 is expressed earlier than Lef1 and that Pyst1 is also expressed early but only transiently. Patterns of expression of Tbx3, Pyst1 and Lef1 in different glands suggest that the order of mammary gland initiation is 3, 4, 1, 2 and 5. Consistent with expression of Pyst1 in the mammary gland, we detected expression of Fgfr1b, Fgf8 and Fgf9 in both surface ectoderm and mammary bud epithelium, and Fgf4 and Fgf17 in mammary bud epithelium. Beads soaked in FGF‐8 applied to the flank of mouse embryos, at a stage just prior to mammary bud initiation, induce expression of Pyst1 and Lef1 and maintain Tbx3 expression in flank tissue surrounding the bead. Grafting beads soaked in the FGFR1 inhibitor, SU5402, abolishes Tbx3, Pyst1 and Lef1 expression, supporting the idea that FGFR1 signalling is required for early mammary gland initiation. We also showed that blocking Wnt signalling abolishes Tbx3 expression but not Pyst1 expression. These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1. |
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AbstractList | Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development. Here we explore how these genes act together in mammary gland initiation. We compared expression of Tbx3, the gene associated with the human condition ulnar–mammary syndrome, expression of the gene encoding the dual‐specificity MAPK phosphatase Pyst1/MKP3, which is an early response to FGFR1 signalling (as judged by sensitivity to the SU5402 inhibitor), and expression of Lef1, encoding a transcription factor mediating Wnt signalling and the earliest gene so far known to be expressed in mammary gland development. We found that Tbx3 is expressed earlier than Lef1 and that Pyst1 is also expressed early but only transiently. Patterns of expression of Tbx3, Pyst1 and Lef1 in different glands suggest that the order of mammary gland initiation is 3, 4, 1, 2 and 5. Consistent with expression of Pyst1 in the mammary gland, we detected expression of Fgfr1b, Fgf8 and Fgf9 in both surface ectoderm and mammary bud epithelium, and Fgf4 and Fgf17 in mammary bud epithelium. Beads soaked in FGF‐8 applied to the flank of mouse embryos, at a stage just prior to mammary bud initiation, induce expression of Pyst1 and Lef1 and maintain Tbx3 expression in flank tissue surrounding the bead. Grafting beads soaked in the FGFR1 inhibitor, SU5402, abolishes Tbx3, Pyst1 and Lef1 expression, supporting the idea that FGFR1 signalling is required for early mammary gland initiation. We also showed that blocking Wnt signalling abolishes Tbx3 expression but not Pyst1 expression. These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1. Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development. Here we explore how these genes act together in mammary gland initiation. We compared expression of Tbx3 , the gene associated with the human condition ulnar–mammary syndrome, expression of the gene encoding the dual-specificity MAPK phosphatase Pyst1 /MKP3, which is an early response to FGFR1 signalling (as judged by sensitivity to the SU5402 inhibitor), and expression of Lef1 , encoding a transcription factor mediating Wnt signalling and the earliest gene so far known to be expressed in mammary gland development. We found that Tbx3 is expressed earlier than Lef1 and that Pyst1 is also expressed early but only transiently. Patterns of expression of Tbx3 , Pyst1 and Lef1 in different glands suggest that the order of mammary gland initiation is 3, 4, 1, 2 and 5. Consistent with expression of Pyst1 in the mammary gland, we detected expression of Fgfr1b , Fgf8 and Fgf9 in both surface ectoderm and mammary bud epithelium, and Fgf4 and Fgf17 in mammary bud epithelium. Beads soaked in FGF-8 applied to the flank of mouse embryos, at a stage just prior to mammary bud initiation, induce expression of Pyst1 and Lef1 and maintain Tbx3 expression in flank tissue surrounding the bead. Grafting beads soaked in the FGFR1 inhibitor, SU5402, abolishes Tbx3 , Pyst1 and Lef1 expression, supporting the idea that FGFR1 signalling is required for early mammary gland initiation. We also showed that blocking Wnt signalling abolishes Tbx3 expression but not Pyst1 expression. These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1. Abstract Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development. Here we explore how these genes act together in mammary gland initiation. We compared expression of Tbx3 , the gene associated with the human condition ulnar–mammary syndrome, expression of the gene encoding the dual‐specificity MAPK phosphatase Pyst1 /MKP3, which is an early response to FGFR1 signalling (as judged by sensitivity to the SU5402 inhibitor), and expression of Lef1 , encoding a transcription factor mediating Wnt signalling and the earliest gene so far known to be expressed in mammary gland development. We found that Tbx3 is expressed earlier than Lef1 and that Pyst1 is also expressed early but only transiently. Patterns of expression of Tbx3 , Pyst1 and Lef1 in different glands suggest that the order of mammary gland initiation is 3, 4, 1, 2 and 5. Consistent with expression of Pyst1 in the mammary gland, we detected expression of Fgfr1b , Fgf8 and Fgf9 in both surface ectoderm and mammary bud epithelium, and Fgf4 and Fgf17 in mammary bud epithelium. Beads soaked in FGF‐8 applied to the flank of mouse embryos, at a stage just prior to mammary bud initiation, induce expression of Pyst1 and Lef1 and maintain Tbx3 expression in flank tissue surrounding the bead. Grafting beads soaked in the FGFR1 inhibitor, SU5402, abolishes Tbx3 , Pyst1 and Lef1 expression, supporting the idea that FGFR1 signalling is required for early mammary gland initiation. We also showed that blocking Wnt signalling abolishes Tbx3 expression but not Pyst1 expression. These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1. |
Author | Kim, Jae‐Young Akita, Keiichi Song, Soo‐Jin Tickle, Cheryll Eblaghie, Maxwell C. Jung, Han‐Sung |
Author_xml | – sequence: 1 givenname: Maxwell C. surname: Eblaghie fullname: Eblaghie, Maxwell C. – sequence: 2 givenname: Soo‐Jin surname: Song fullname: Song, Soo‐Jin – sequence: 3 givenname: Jae‐Young surname: Kim fullname: Kim, Jae‐Young – sequence: 4 givenname: Keiichi surname: Akita fullname: Akita, Keiichi – sequence: 5 givenname: Cheryll surname: Tickle fullname: Tickle, Cheryll – sequence: 6 givenname: Han‐Sung surname: Jung fullname: Jung, Han‐Sung |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15255957$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S1567-133X(03)00092-9 10.1016/0012-1606(78)90311-1 10.1242/dev.125.7.1285 10.1126/science.280.5367.1274 10.1038/74231 10.1002/dvdy.10208 10.1128/MCB.12.5.2418 10.1126/science.276.5314.955 10.1006/dbio.2002.0762 10.1016/0925-4773(95)00383-5 10.1016/S0092-8674(01)00285-9 10.1016/0076-6879(93)25025-W 10.1016/S0925-4773(02)00024-2 10.1016/S1534-5807(01)00064-8 10.1002/em.10064 10.1046/j.1432-0436.1994.5730205.x 10.1101/gad.8.22.2691 10.1016/S0960-9822(03)00381-6 10.1242/dev.127.18.4011 10.1242/dev.00473 10.1006/dbio.2001.0410 10.1006/dbio.1998.8850 10.1242/dev.126.20.4557 10.1002/j.1460-2075.1994.tb06769.x 10.1210/endo.141.8.7609 10.1101/gad.1035602 10.1006/bbrc.1995.1572 10.1242/dev.00431 10.1046/j.1432-0436.2003.700601.x 10.1038/ng0797-311 10.1242/dev.00345 10.1242/dev.129.1.53 10.1242/dev.122.9.2729 10.1677/erc.0.0080211 10.1016/0092-8674(95)90352-6 10.1128/MCB.14.9.6278 10.1242/dev.00474 10.1242/dev.125.19.3887 10.1016/S0306-4522(01)00411-0 10.1074/jbc.271.25.15292 10.1242/dev.126.22.5181 10.1016/S0091-679X(08)60630-5 10.1016/S0960-9822(95)00017-0 10.1111/j.1468-2230.1993.tb00961.x 10.1006/dbio.1995.1236 10.1002/(SICI)1097-0177(199608)206:4<379::AID-AJA4>3.0.CO;2-F |
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References | 2002; 39 1995; 51 1998; 280 2002; 15 2002; 113 1988; 37 1997; 276 1933; 182 1996; 51 2003; 17 1996; 122 2001; 108 2003; 71 2001; 23 1999; 126 1992; 12 1993; 225 1996; 206 1995; 5 1995; 170 2003; 130 1998; 196 1993; 56 1995; 80 2003; 226 1978; 67 2000; 127 1995; 209 2002; 24 2001; 8 2002; 129 2003; 3 1994; 14 1997; 16 2000; 141 1994; 57 1998; 125 1994; 15 2001; 1 1994; 3 1996; 21 2001; 238 8853987 - Dev Dyn. 1996 Aug;206(4):379-90 9596583 - Science. 1998 May 22;280(5367):1274-7 12376101 - Dev Biol. 2002 Oct 15;250(2):251-62 10529434 - Development. 1999 Nov;126(22):5181-93 8663044 - J Biol Chem. 1996 Jun 21;271(25):15292-7 12972005 - Gene Expr Patterns. 2003 Oct;3(5):675-9 7925289 - EMBO J. 1994 Oct 3;13(19):4469-81 8065359 - Mol Cell Biol. 1994 Sep;14(9):6278-86 11782400 - Development. 2002 Jan;129(1):53-60 7988795 - Differentiation. 1994 Sep;57(3):205-14 11652316 - Mod Law Rev. 1993 Mar;56(2):238-43 2463825 - Arerugi. 1988 Jul;37(7):438-47 11566612 - Endocr Relat Cancer. 2001 Sep;8(3):211-7 12588840 - Development. 2003 Apr;130(7):1225-34 1373817 - Mol Cell Biol. 1992 May;12(5):2418-23 11734354 - Neuroscience. 2001;108(2):183-206 8231863 - Methods Enzymol. 1993;225:361-73 7535172 - Curr Biol. 1995 Jan 1;5(1):62-7 8674413 - Development. 1996 Jun;122(6):1737-50 11921187 - Environ Mol Mutagen. 2002;39(2-3):178-83 12736216 - Development. 2003 Jun;130(12):2729-39 720754 - Dev Biol. 1978 Nov;67(1):225-31 10952899 - Development. 2000 Sep;127(18):4011-21 12668638 - Development. 2003 May;130(10):2263-73 9207801 - Nat Genet. 1997 Jul;16(3):311-5 9139660 - Science. 1997 May 9;276(5314):955-60 8722478 - Methods Cell Biol. 1996;51:219-35 12736217 - Development. 2003 Jun;130(12):2741-51 10919287 - Endocrinology. 2000 Aug;141(8):2982-94 11960712 - Mech Dev. 2002 May;113(2):193-6 9477327 - Development. 1998 Apr;125(7):1285-94 12508227 - Dev Dyn. 2003 Jan;226(1):82-90 11783999 - Dev Biol. 2001 Oct 1;238(1):133-44 12814546 - Curr Biol. 2003 Jun 17;13(12):1009-18 7958926 - Genes Dev. 1994 Nov 15;8(22):2691-703 10742104 - Nat Genet. 2000 Apr;24(4):391-5 11290326 - Cell. 2001 Mar 23;104(6):891-900 12502739 - Genes Dev. 2002 Dec 15;16(24):3173-85 9729496 - Development. 1998 Oct;125(19):3887-94 9527877 - Dev Biol. 1998 Apr 1;196(1):11-23 7649383 - Dev Biol. 1995 Aug;170(2):553-63 8787747 - Development. 1996 Sep;122(9):2729-37 7547479 - Mech Dev. 1995 Jun;51(2-3):341-50 11703938 - Dev Cell. 2001 Oct;1(4):467-75 7889567 - Cell. 1995 Mar 10;80(5):739-46 7733973 - Biochem Biophys Res Commun. 1995 Apr 26;209(3):809-16 10498690 - Development. 1999 Oct;126(20):4557-68 12558599 - Differentiation. 2003 Jan;71(1):1-17 e_1_2_6_32_1 e_1_2_6_30_1 Vogel A (e_1_2_6_46_1) 1996; 122 e_1_2_6_19_1 Tanaka M (e_1_2_6_42_1) 2000; 127 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_11_1 Isaacs HV (e_1_2_6_18_1) 1994; 3 e_1_2_6_34_1 e_1_2_6_17_1 e_1_2_6_15_1 e_1_2_6_38_1 Turner CW (e_1_2_6_44_1) 1933; 182 e_1_2_6_20_1 Ornitz DM (e_1_2_6_31_1) 1996; 21 e_1_2_6_41_1 e_1_2_6_9_1 e_1_2_6_5_1 e_1_2_6_7_1 e_1_2_6_24_1 e_1_2_6_49_1 e_1_2_6_3_1 e_1_2_6_22_1 e_1_2_6_28_1 e_1_2_6_45_1 e_1_2_6_26_1 e_1_2_6_47_1 Satokata I (e_1_2_6_37_1) 2002; 24 e_1_2_6_10_1 e_1_2_6_50_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_39_1 e_1_2_6_16_1 Kawashima T (e_1_2_6_21_1) 1988; 37 e_1_2_6_40_1 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 Tumpel S (e_1_2_6_43_1) 2002; 15 e_1_2_6_27_1 |
References_xml | – volume: 39 start-page: 178 year: 2002 end-page: 183 article-title: Environmental carcinogens and p53 tumor‐suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis publication-title: Environ. Mol. Mutagen. – volume: 57 start-page: 205 year: 1994 end-page: 214 article-title: Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland publication-title: Differentiation – volume: 125 start-page: 3887 year: 1998 end-page: 3894 article-title: The T‐box transcription factor Brachyury regulates expression of eFGF through binding to a non‐palindromic response element publication-title: Development – volume: 130 start-page: 2741 year: 2003 end-page: 2751 article-title: Tbx5 is required for forelimb bud formation and continued outgrowth publication-title: Development – volume: 16 start-page: 311 year: 1997 end-page: 315 article-title: Mutations in human TBX3 alter limb, apocrine and genital development in ulnar–mammary syndrome publication-title: Nat. Genet. – volume: 15 start-page: 3173 year: 2002 end-page: 3185 article-title: FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1 (‐/‐) mice publication-title: Genes Dev. – volume: 225 start-page: 361 year: 1993 end-page: 373 article-title: Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts publication-title: Methods Enzymol. – volume: 37 start-page: 438 year: 1988 end-page: 447 article-title: Inhibition of chemical mediator release from human leukocytes and lung fragments by TBX publication-title: Arerugi – volume: 15 start-page: 251 year: 2002 end-page: 262 article-title: Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development publication-title: Dev. Biol. – volume: 71 start-page: 117 year: 2003 article-title: Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation publication-title: Differentiation – volume: 80 start-page: 739 year: 1995 end-page: 746 article-title: Fibroblast growth factors induce additional limb development from the flank of chick embryos publication-title: Cell – volume: 196 start-page: 11 year: 1998 end-page: 23 article-title: Local inhibitory action of BMPs and their relationships with activators in feather formation: implications for periodic patterning publication-title: Dev. Biol. – volume: 182 start-page: 3 year: 1933 end-page: 20 article-title: The normal development of the mammary gland of the male and female albino mouse. I. Intrauterine publication-title: Mo. Agric. Exp. Stn. Res. Bull. – volume: 129 start-page: 53 year: 2002 end-page: 60 article-title: Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo publication-title: Development – volume: 14 start-page: 6278 year: 1994 end-page: 6286 article-title: Differential transformation of mammary epithelial cells by Wnt genes publication-title: Mol. Cell. Biol. – volume: 170 start-page: 553 year: 1995 end-page: 563 article-title: Wnt‐4 expression induces a pregnancy‐like growth pattern in reconstituted mammary glands in virgin mice publication-title: Dev. Biol. – volume: 8 start-page: 211 year: 2001 end-page: 217 article-title: Fibroblast growth factor signalling in mouse mammary gland development publication-title: Endocr. Relat. Cancer. – volume: 125 start-page: 1285 year: 1998 end-page: 1294 article-title: Rescue of the parathyroid hormone‐related protein knockout mouse demonstrates that parathyroid hormone‐related protein is essential for mammary gland development publication-title: Development – volume: 3 start-page: 4469 year: 1994 end-page: 4481 article-title: eFGF regulates Xbra expression during gastrulation publication-title: EMBO J. – volume: 15 start-page: 2691 year: 1994 end-page: 2703 article-title: Development of several organs that require inductive epithelial–mesenchymal interations is impaired in LEF‐1‐deficient mice publication-title: Genes Dev. – volume: 12 start-page: 2418 year: 1992 end-page: 2423 article-title: Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland publication-title: Mol. Cell Biol. – volume: 113 start-page: 193 year: 2002 end-page: 196 article-title: Expression of the ERK‐specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis publication-title: Mech. Dev. – volume: 130 start-page: 2263 year: 2003 end-page: 2273 article-title: Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome publication-title: Development – volume: 126 start-page: 5181 year: 1999 end-page: 5193 article-title: Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched‐1 publication-title: Development – volume: 51 start-page: 342 year: 1995 end-page: 350 article-title: Murine Wnt‐11 and Wnt‐12 have temporally and spatially restricted expression patterns during embryonic development publication-title: Mech. Dev. – volume: 51 start-page: 219 year: 1996 end-page: 235 article-title: In situ hybridization analysis of chick embryos in whole mount and tissue sections publication-title: Methods Cell Biol. – volume: 21 start-page: 15292 year: 1996 end-page: 15297 article-title: Receptor specificity of the fibroblast growth factor family publication-title: J. Biol. Chem. – volume: 56 start-page: 238 year: 1993 end-page: 243 article-title: Court‐ordered caesarian sections: in whose interests publication-title: Mod. Law. Rev. – volume: 23 start-page: 891 year: 2001 end-page: 900 article-title: WNT signals control FGF‐dependent limb initiation and AER induction in the chick embryo publication-title: Cell – volume: 3 start-page: 675 year: 2003 end-page: 679 article-title: Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis publication-title: Gene Expr. Patterns – volume: 1 start-page: 467 year: 2001 end-page: 475 article-title: Signaling pathways in mammary gland development publication-title: Dev. Cell – volume: 206 start-page: 379 year: 1996 end-page: 390 article-title: Expression of the T‐box family genes, Tbx1–Tbx5, during early mouse development publication-title: Dev. Dyn. – volume: 209 start-page: 809 year: 1995 end-page: 816 article-title: An additional limb can be induced from the flank of the chick embryo by FGF4 publication-title: Biochem. Biophys. Res. Commun. – volume: 122 start-page: 1737 year: 1996 end-page: 1750 article-title: Involvement of FGF‐8 in initiation, outgrowth and patterning of the vertebrate limb publication-title: Develoment – volume: 24 start-page: 391 year: 2002 end-page: 395 article-title: Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation publication-title: Nat. Genet. – volume: 17 start-page: 1009 year: 2003 end-page: 1018 article-title: Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos publication-title: Current Biol. – volume: 141 start-page: 2982 year: 2000 end-page: 2994 article-title: Induction of mammary gland development in estrogen receptor‐alpha knockout mice publication-title: Endocrinology – volume: 226 start-page: 82 year: 2003 end-page: 90 article-title: T‐box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung publication-title: Dev. Dyn. – volume: 122 start-page: 2729 year: 1996 end-page: 2737 article-title: Regulation of Msx‐1, Msx‐2, Bmp‐2 and Bmp‐4 during foetal and postnatal mammary gland development publication-title: Development – volume: 280 start-page: 1274 year: 1998 end-page: 1277 article-title: Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud publication-title: Science – volume: 276 start-page: 955 year: 1997 end-page: 960 article-title: Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors publication-title: Science – volume: 127 start-page: 4011 year: 2000 end-page: 4021 article-title: Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly publication-title: Development – volume: 67 start-page: 225 year: 1978 end-page: 231 article-title: Wandering epithelial cells in the rabbit embryos milk line publication-title: Dev. Biol. – volume: 5 start-page: 62 year: 1995 end-page: 67 article-title: Mesoderm formation in response to Brachyury requires FGF signalling publication-title: Curr. Biol. – volume: 108 start-page: 183 year: 2001 end-page: 206 article-title: Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles publication-title: Neuroscience – volume: 130 start-page: 1225 year: 2003 end-page: 1234 article-title: Tbx4–Fgf10 system controls lung bud formation during chicken embryonic development publication-title: Development – volume: 130 start-page: 2729 year: 2003 end-page: 2739 article-title: Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade publication-title: Development – volume: 126 start-page: 4557 year: 1999 end-page: 4568 article-title: Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation publication-title: Development – volume: 238 start-page: 133 year: 2001 end-page: 144 article-title: The Gli2 transcription factor is required for normal mouse mammary gland development publication-title: Dev. Biol. – ident: e_1_2_6_33_1 doi: 10.1016/S1567-133X(03)00092-9 – ident: e_1_2_6_34_1 doi: 10.1016/0012-1606(78)90311-1 – ident: e_1_2_6_50_1 doi: 10.1242/dev.125.7.1285 – ident: e_1_2_6_22_1 doi: 10.1126/science.280.5367.1274 – volume: 24 start-page: 391 year: 2002 ident: e_1_2_6_37_1 article-title: Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation publication-title: Nat. Genet. doi: 10.1038/74231 contributor: fullname: Satokata I – ident: e_1_2_6_6_1 doi: 10.1002/dvdy.10208 – ident: e_1_2_6_15_1 doi: 10.1128/MCB.12.5.2418 – ident: e_1_2_6_28_1 doi: 10.1126/science.276.5314.955 – volume: 15 start-page: 251 year: 2002 ident: e_1_2_6_43_1 article-title: Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development publication-title: Dev. Biol. doi: 10.1006/dbio.2002.0762 contributor: fullname: Tumpel S – ident: e_1_2_6_8_1 doi: 10.1016/0925-4773(95)00383-5 – ident: e_1_2_6_20_1 doi: 10.1016/S0092-8674(01)00285-9 – ident: e_1_2_6_48_1 doi: 10.1016/0076-6879(93)25025-W – ident: e_1_2_6_13_1 doi: 10.1016/S0925-4773(02)00024-2 – ident: e_1_2_6_17_1 doi: 10.1016/S1534-5807(01)00064-8 – ident: e_1_2_6_27_1 doi: 10.1002/em.10064 – ident: e_1_2_6_47_1 doi: 10.1046/j.1432-0436.1994.5730205.x – ident: e_1_2_6_16_1 doi: 10.1101/gad.8.22.2691 – ident: e_1_2_6_14_1 doi: 10.1016/S0960-9822(03)00381-6 – volume: 127 start-page: 4011 year: 2000 ident: e_1_2_6_42_1 article-title: Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly publication-title: Development doi: 10.1242/dev.127.18.4011 contributor: fullname: Tanaka M – ident: e_1_2_6_35_1 doi: 10.1242/dev.00473 – ident: e_1_2_6_24_1 doi: 10.1006/dbio.2001.0410 – ident: e_1_2_6_19_1 doi: 10.1006/dbio.1998.8850 – ident: e_1_2_6_11_1 doi: 10.1242/dev.126.20.4557 – volume: 3 start-page: 4469 year: 1994 ident: e_1_2_6_18_1 article-title: eFGF regulates Xbra expression during Xenopus gastrulation publication-title: EMBO J. doi: 10.1002/j.1460-2075.1994.tb06769.x contributor: fullname: Isaacs HV – ident: e_1_2_6_3_1 doi: 10.1210/endo.141.8.7609 – ident: e_1_2_6_23_1 doi: 10.1101/gad.1035602 – volume: 37 start-page: 438 year: 1988 ident: e_1_2_6_21_1 article-title: Inhibition of chemical mediator release from human leukocytes and lung fragments by TBX publication-title: Arerugi contributor: fullname: Kawashima T – ident: e_1_2_6_30_1 doi: 10.1006/bbrc.1995.1572 – ident: e_1_2_6_12_1 doi: 10.1242/dev.00431 – ident: e_1_2_6_45_1 doi: 10.1046/j.1432-0436.2003.700601.x – ident: e_1_2_6_2_1 doi: 10.1038/ng0797-311 – ident: e_1_2_6_36_1 doi: 10.1242/dev.00345 – ident: e_1_2_6_26_1 doi: 10.1242/dev.129.1.53 – ident: e_1_2_6_32_1 doi: 10.1242/dev.122.9.2729 – ident: e_1_2_6_39_1 doi: 10.1677/erc.0.0080211 – ident: e_1_2_6_9_1 doi: 10.1016/0092-8674(95)90352-6 – volume: 122 start-page: 1737 year: 1996 ident: e_1_2_6_46_1 article-title: Involvement of FGF‐8 in initiation, outgrowth and patterning of the vertebrate limb publication-title: Develoment contributor: fullname: Vogel A – ident: e_1_2_6_49_1 doi: 10.1128/MCB.14.9.6278 – ident: e_1_2_6_41_1 doi: 10.1242/dev.00474 – ident: e_1_2_6_5_1 doi: 10.1242/dev.125.19.3887 – ident: e_1_2_6_10_1 doi: 10.1016/S0306-4522(01)00411-0 – volume: 182 start-page: 3 year: 1933 ident: e_1_2_6_44_1 article-title: The normal development of the mammary gland of the male and female albino mouse. I. Intrauterine publication-title: Mo. Agric. Exp. Stn. Res. Bull. contributor: fullname: Turner CW – volume: 21 start-page: 15292 year: 1996 ident: e_1_2_6_31_1 article-title: Receptor specificity of the fibroblast growth factor family publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.25.15292 contributor: fullname: Ornitz DM – ident: e_1_2_6_25_1 doi: 10.1242/dev.126.22.5181 – ident: e_1_2_6_29_1 doi: 10.1016/S0091-679X(08)60630-5 – ident: e_1_2_6_38_1 doi: 10.1016/S0960-9822(95)00017-0 – ident: e_1_2_6_40_1 doi: 10.1111/j.1468-2230.1993.tb00961.x – ident: e_1_2_6_4_1 doi: 10.1006/dbio.1995.1236 – ident: e_1_2_6_7_1 doi: 10.1002/(SICI)1097-0177(199608)206:4<379::AID-AJA4>3.0.CO;2-F |
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Snippet | Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development.... Abstract Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland... |
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SubjectTerms | Animals DNA-Binding Proteins - genetics Dual Specificity Phosphatase 6 embryonic mammary gland Female Fgfs Fibroblast Growth Factor 4 Fibroblast Growth Factor 8 Fibroblast Growth Factor 9 Fibroblast Growth Factors - genetics Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics In Situ Hybridization - methods Lymphoid Enhancer-Binding Factor 1 Male Mammary Glands, Animal - embryology Mice Mice, Inbred Strains Organ Culture Techniques Original Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - genetics Protein-Tyrosine Kinases - antagonists & inhibitors Proto-Oncogene Proteins - genetics Pyrroles - pharmacology Receptor Protein-Tyrosine Kinases - genetics Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - genetics Signal Transduction T-Box Domain Proteins - genetics Transcription Factors - genetics T‐box Wnt Wnt Proteins |
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Title | Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos |
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