Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF

• Published in: The FEBS journal Vol. 275; no. 8; pp. 1631 - 1642
• Main Authors: Shaharabany, Miriam, Holtzman, Eliezer J, Mayan, Haim, Hirschberg, Koret, Seger, Rony, Farfel, Zvi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.04.2008; Blackwell Publishing Ltd
• Subjects: Biochemistry; Cell Line; Cell Shape - drug effects; cell traffic; Cellular biology; EGF; Epidermal Growth Factor - metabolism; Frogs; Gene Expression Regulation - drug effects; Genes, Reporter - genetics; Genetic disorders; Humans; Hypertonic Solutions; hypertonicity; Kinases; Mutation; Osmotic Pressure; signal transduction; Signal Transduction - drug effects; Sodium Chloride - pharmacology; WNK kinase; Wnt Proteins - genetics; Wnt Proteins - metabolism; Wnt4 Protein

WNK4 kinase mutations produce the autosomal dominant disorder familial hyperkalemia and hypertension (FHH), also known as pseudohypoaldosteronism type II, by a molecular mechanism that is not completely understood. In vitro experiments in frog oocytes showed that WNK4 affects ion transport systems s...