Risk of digoxin intoxication in heart failure patients exposed to digoxin–diuretic interactions: a population‐based study

• Published in: British journal of clinical pharmacology Vol. 70; no. 2; pp. 258 - 267
• Main Authors: Wang, Meng‐Ting, Su, Chen‐Yi, Chan, Agnes L. F., Lian, Pei‐Wen, Leu, Hsin‐Bang, Hsu, Yu‐Juei
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2010; Blackwell; Blackwell Science Inc
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Cardiology. Vascular system; Cardiotonic Agents - adverse effects; Cardiotonic Agents - therapeutic use; Case-Control Studies; Cohort Studies; digoxin; Digoxin - adverse effects; Digoxin - therapeutic use; digoxin intoxication; digoxin–diuretic interactions; Diuretics; Diuretics - adverse effects; Diuretics - therapeutic use; Drug Interactions; Drug Safety; Drug Therapy, Combination; Female; Heart; Heart diseases; Heart Failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hospitalization - statistics & numerical data; Humans; Hydrochlorothiazide; Intoxication; Male; Medical sciences; Middle Aged; nested case–control study; Pharmacology. Drug treatments; Retrospective Studies; Risk factors; Human; Heart failure; Drug; Cardiotonic agent; Digoxin; Toxicity; Interaction; drug safety; Cardiovascular disease; nested case-control study; Case control study; Diuretic; digoxin-diuretic interactions; Heart disease; Risk factor; Glycoside; Poisoning; Safety; Digitalis drug; Public health; digoxin intoxication
• ISSN: 0306-5251; 1365-2125; 1365-2125
• DOI: 10.1111/j.1365-2125.2010.03687.x

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Increased frequency of electrolyte abnormalities and cardiac arrhythmias among patients exposed to digoxin–diuretic interactions has been well‐documented in numerous descriptive studies. • Nonetheless, a clear causal relationship has not been established in...