Ribosome-based quality control of mRNA and nascent peptides

• Published in: Wiley interdisciplinary reviews. RNA Vol. 8; no. 1
• Main Authors: Simms, Carrie L, Thomas, Erica N, Zaher, Hani S
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Animals; Humans; Peptide Chain Elongation, Translational; Peptide Chain Termination, Translational; Protein Biosynthesis; Ribosomes - genetics; RNA, Messenger - genetics

Quality control processes are widespread and play essential roles in detecting defective molecules and removing them in order to maintain organismal fitness. Aberrant messenger RNA (mRNA) molecules, unless properly managed, pose a significant hurdle to cellular proteostasis. Often mRNAs harbor prema...