β-Site amyloid precursor protein–cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau

• Published in: Alzheimer's & dementia Vol. 9; no. 4; pp. 386 - 391
• Main Authors: Tsolakidou, Amalia, Alexopoulos, Panagiotis, Guo, Liang-Hao, Grimmer, Timo, Westerteicher, Christine, Kratzer, Martina, Jiang, Meizi, Bujo, Hideaki, Roselli, Francesco, Leante, Maria Rosaria, Livrea, Paolo, Kurz, Alexander, Perneczky, Robert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2013
• Subjects: Adult; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Protein Precursor - cerebrospinal fluid; Amyloid beta-Protein Precursor - metabolism; Amyloid cascade; Amyloid Precursor Protein Secretases - cerebrospinal fluid; Aspartic Acid Endopeptidases - cerebrospinal fluid; Biomarker; Biomarkers; Cerebrospinal fluid; Dementia; Female; Humans; LDL-Receptor Related Proteins - cerebrospinal fluid; Male; Membrane Transport Proteins - cerebrospinal fluid; Metabolism; Middle Aged; Neurology; Pathology; Peptide Fragments - cerebrospinal fluid; Precursors; Proteins; Psychometrics; Retrograde Degeneration; tau Proteins - cerebrospinal fluid; β-secretase; β-secretase; Biomarker; Alzheimer’s disease; Dementia; Amyloid cascade

Abstract Background β-Site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer’s disease (AD). Methods The present study explored the correlation...