Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria

• Published in: Microbial biotechnology Vol. 17; no. 4; pp. e14465 - n/a
• Main Authors: Zheng, Tianyu, Zhang, Can
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2024; John Wiley and Sons Inc; Wiley
• Subjects: Antibacterial agents; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Bacteria; Bacterial infections; Drug resistance; Genes; Genomes; Gram-negative bacteria; Gram-positive bacteria; Membranes; Mini Review; Mini Reviews; Molecular weight; Pathogens; Peptidoglycans; Phages; Prevention; Proteins

Bacteriophage endolysin is a novel antibacterial agent that has attracted much attention in the prevention and control of drug‐resistant bacteria due to its unique mechanism of hydrolysing peptidoglycans. Although endolysin exhibits excellent bactericidal effects on Gram‐positive bacteria, the prese...