Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

• Published in: Circulation (New York, N.Y.) Vol. 147; no. 11; pp. 867 - 876
• Main Authors: Yonker, Lael M., Swank, Zoe, Bartsch, Yannic C., Burns, Madeleine D., Kane, Abigail, Boribong, Brittany P., Davis, Jameson P., Loiselle, Maggie, Novak, Tanya, Senussi, Yasmeen, Cheng, Chi-An, Burgess, Eleanor, Edlow, Andrea G., Chou, Janet, Dionne, Audrey, Balaguru, Duraisamy, Lahoud-Rahme, Manuella, Arditi, Moshe, Julg, Boris, Randolph, Adrienne G., Alter, Galit, Fasano, Alessio, Walt, David R.
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 14.03.2023
• Subjects: Adolescent; Antibodies, Viral; Autoantibodies; Child; COVID-19 - prevention & control; COVID-19 Vaccines - adverse effects; Cytokines; Humans; Myocarditis - etiology; Original s; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Young Adult; COVID-19; SARS-CoV-2; vaccine; mRNA; myocarditis

Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail. From January...