Biocompatibility and osteogenesis of calcium phosphate composite scaffolds containing simvastatin-loaded PLGA microspheres for bone tissue engineering

• Published in: Journal of biomedical materials research. Part A Vol. 103; no. 10; pp. 3250 - 3258
• Main Authors: Zhang, Hao-Xuan, Xiao, Gui-Yong, Wang, Xia, Dong, Zhao-Gang, Ma, Zhi-Yong, Li, Lei, Li, Yu-Hua, Pan, Xin, Nie, Lin
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: Animals; Biocompatibility; Biomedical materials; bone defect; bone mesenchymal stem cells; Bone Substitutes - chemistry; bone tissue engineering; Bones; Calcium phosphate; Cells, Cultured; Lactic Acid - chemistry; Materials Testing; Microspheres; Morphology; Osteogenesis - drug effects; Polyglycolic Acid - chemistry; Rabbits; Scaffolds; simvastatin; Simvastatin - chemistry; Simvastatin - pharmacology; Surgical implants; Tissue Engineering; Tissue Scaffolds - chemistry; simvastatin; bone defect; scaffolds; bone tissue engineering; bone mesenchymal stem cells

By utilizing a modified solid/oil/water (s/o/w) emulsion solvent evaporation technique, calcium phosphate composite scaffolds containing simvastatin‐loaded PLGA microspheres (SIM‐PLGA‐CPC) were prepared in this study. We characterized the morphology, encapsulation efficiency and in vitro drug releas...