Assessing the Validity of Adult‐derived Prognostic Models for Primary Sclerosing Cholangitis Outcomes in Children

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 70; no. 1; pp. e12 - e17
• Main Authors: Deneau, Mark R., Valentino, Pamela L., Mack, Cara, Alqoaer, Khaled, Amin, Mansi, Amir, Achiya Z., Aumar, Madeleine, Auth, Marcus, Broderick, Annemarie, DiGuglielmo, Matthew, Draijer, Laura G., El‐Matary, Wael, Ferrari, Federica, Furuya, Katryn N., Gottrand, Frederic, Gupta, Nitika, Homan, Matjaz, Jensen, M.K., Kamath, Binita M., Kim, Kyung Mo, Kolho, Kaija‐Leena, Koot, Bart, Iorio, Raffaele, Martinez, Mercedes, Miloh, Tamir, Mohan, Parvathi, Palle, Sirish, Papadopoulou, Alexandra, Ricciuto, Amanda, Saubermann, Lawrence, Sathya, Pushpa, Shteyer, Eyal, Smolka, Vratislav, Tanaka, Atsushi, Varier, Raghu, Venkat, Veena, Vitola, Bernadette, Woynarowski, Marek, Guthery, Stephen
• Format: Journal Article
• Language: English
• Published: United States by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition 01.01.2020; by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology; Lippincott, Williams & Wilkins
• Series: Journal of Pediatric Gastroenterology and Nutrition
• Subjects: Child; Cholangitis, Sclerosing - complications; Cholangitis, Sclerosing - mortality; Female; Gastroenterology - methods; Hepatitis, Autoimmune - complications; Hepatitis, Autoimmune - mortality; Humans; Kaplan-Meier Estimate; Life Sciences; Liver Function Tests - methods; Male; Models, Statistical; natural history; pediatric; Pediatrics - methods; Predictive Value of Tests; primary sclerosing cholangitis; Prognosis; Reproducibility of Results; Risk Assessment - methods; risk stratification; risk stratification; prognosis; natural history; primary sclerosing cholangitis; pediatric

ABSTRACT Background: Natural history models for primary sclerosing cholangitis (PSC) are derived from adult patient data, but have never been validated in children. It is unclear how accurate such models are for children with PSC. Methods: We utilized the pediatric PSC consortium database to assess...