Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation

• Published in: British journal of clinical pharmacology Vol. 70; no. 6; pp. 886 - 894
• Main Authors: Chen, Christopher L. H., Willis, Brian A., Mooney, Louise, Ong, Guan Koon, Lim, Chay Ngee, Lowe, Stephen L., Tauscher‐Wisniewski, Sitra, Cutler Jr, Gordon B., Wiss, Stephen D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2010; Blackwell; Blackwell Science Inc
• Subjects: Adult; Biological and medical sciences; biomarkers; Biomarkers - blood; Blood Glucose - metabolism; Central nervous system; cortisol; Humans; Hydrocortisone; Hydrocortisone - blood; Hydrocortisone - secretion; hypoglycaemia; Hypoglycemia - chemically induced; Hypoglycemia - metabolism; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - pharmacology; hypothalamic‐pituitary‐adrenocortical axis; Hypothalamo-Hypophyseal System - drug effects; Hypothalamo-Hypophyseal System - metabolism; Insulin; Insulin - administration & dosage; Insulin - pharmacology; insulin infusion; insulin tolerance test; Male; Medical sciences; Methods in Clinical Pharmacology; Middle Aged; Pharmacology. Drug treatments; Pilot Projects; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - metabolism; Stress, Physiological - physiology; Young Adult; Corticosteroid; Pancreatic hormone; Steroid hormone; Toxicity; hypoglycaemia; Antiinflammatory agent; Central nervous system; insulin infusion; Biological marker; Tolerance; Metabolic diseases; Cortisol; hypothalamic-pituitary-adrenocortical axis; insulin tolerance test; Hydrocortisone; Hypoglycemia; Glucocorticoid; Insulin; Infusion; Perfusion; Adrenal hormone; Hypothalamohypophysocorticoadrenal axis

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The insulin tolerance test (ITT) is commonly used to induce cortisol release in response to physiological stress. This methodology can be employed in studies evaluating the hypothalamic‐pituitary‐adrenocortical axis. WHAT THIS STUDY ADDS • An exploration of...