OVO-like 1 regulates progenitor cell fate in human trophoblast development

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 45; pp. E6175 - E6184
• Main Authors: Renaud, Stephen J., Chakraborty, Damayanti, Mason, Clifford W., Rumi, M. A. Karim, Vivian, Jay L., Soares, Michael J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.11.2015; National Acad Sciences
• Series: PNAS Plus
• Subjects: Analysis of Variance; Animals; Base Sequence; Biological Sciences; Blotting, Western; Cell Differentiation - physiology; Cells; Chromatin Immunoprecipitation; DNA-Binding Proteins - metabolism; Female; Fluorescent Antibody Technique; Gases; Gene Expression Regulation, Developmental - physiology; Genes; Humans; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred C57BL; Microarray Analysis; Molecular Sequence Data; Nutrients; Placenta; PNAS Plus; Pregnancy; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering - genetics; Sequence Analysis, RNA; Stem Cells - physiology; Tissues; Transcription Factors - metabolism; Trophoblasts - cytology; Trophoblasts - physiology; placenta; differentiation; epithelial barrier; OVO-like 1; trophoblast

Epithelial barrier integrity is dependent on progenitor cells that either divide to replenish themselves or differentiate into a specialized epithelium. This paradigm exists in human placenta, where cytotrophoblast cells either propagate or undergo a unique differentiation program: fusion into an ov...