LOX-1 rewires glutamine ammonia metabolism to drive liver fibrosis

• Published in: Molecular metabolism (Germany) Vol. 96; p. 102132
• Main Authors: Huang, Ruihua, Cui, Hanyu, Yahya Ali Alshami, Mohammed Abdulaziz, Fu, Chuankui, Jiang, Wei, Cai, Mingyuan, Zhou, Shuhan, Zhu, Xiaoyun, Hu, Changping
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.06.2025; Elsevier
• Subjects: Ammonia - metabolism; Animals; GLS; Glutaminase - metabolism; Glutamine - metabolism; Hepatic Stellate Cells - metabolism; Humans; Liver - metabolism; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver fibrosis; LOX-1; Male; Mice; Original; Rats; Rats, Sprague-Dawley; Scavenger Receptors, Class E - genetics; Scavenger Receptors, Class E - metabolism; Urea cycle; Urea cycle; Liver fibrosis; LOX-1; GLS

Liver fibrosis is a crucial condition for evaluating the prognosis of chronic liver disease. Lectin-1ike oxidized low density lipoprotein receptor-1 (LOX-1) has been shown potential research value and therapeutic targeting possibilities in different fibrotic diseases. However, the role of LOX-1 and...